BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 28418242)

  • 1. Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.
    Barniol-Xicota M; Gazzarrini S; Torres E; Hu Y; Wang J; Naesens L; Moroni A; Vázquez S
    J Med Chem; 2017 May; 60(9):3727-3738. PubMed ID: 28418242
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses.
    Hu Y; Musharrafieh R; Ma C; Zhang J; Smee DF; DeGrado WF; Wang J
    Antiviral Res; 2017 Apr; 140():45-54. PubMed ID: 28087313
    [TBL] [Abstract][Full Text] [Related]  

  • 3. New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode.
    Rey-Carrizo M; Gazzarrini S; Llabrés S; Frigolé-Vivas M; Juárez-Jiménez J; Font-Bardia M; Naesens L; Moroni A; Luque FJ; Vázquez S
    Eur J Med Chem; 2015; 96():318-29. PubMed ID: 25899336
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
    Rey-Carrizo M; Torres E; Ma C; Barniol-Xicota M; Wang J; Wu Y; Naesens L; DeGrado WF; Lamb RA; Pinto LH; Vázquez S
    J Med Chem; 2013 Nov; 56(22):9265-74. PubMed ID: 24237039
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N/L26I and M2-S31N/V27A from the influenza A viruses.
    Musharrafieh R; Ma C; Wang J
    Eur J Pharm Sci; 2020 Jan; 141():105124. PubMed ID: 31669761
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.
    Rey-Carrizo M; Barniol-Xicota M; Ma C; Frigolé-Vivas M; Torres E; Naesens L; Llabrés S; Juárez-Jiménez J; Luque FJ; DeGrado WF; Lamb RA; Pinto LH; Vázquez S
    J Med Chem; 2014 Jul; 57(13):5738-47. PubMed ID: 24941437
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.
    Dong J; Chen S; Li R; Cui W; Jiang H; Ling Y; Yang Z; Hu W
    Eur J Med Chem; 2016 Jan; 108():605-615. PubMed ID: 26722757
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus.
    Balannik V; Wang J; Ohigashi Y; Jing X; Magavern E; Lamb RA; Degrado WF; Pinto LH
    Biochemistry; 2009 Dec; 48(50):11872-82. PubMed ID: 19905033
    [TBL] [Abstract][Full Text] [Related]  

  • 9. X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.
    Thomaston JL; Konstantinidi A; Liu L; Lambrinidis G; Tan J; Caffrey M; Wang J; Degrado WF; Kolocouris A
    Biochemistry; 2020 Feb; 59(4):627-634. PubMed ID: 31894969
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors.
    Wu S; Huang J; Gazzarrini S; He S; Chen L; Li J; Xing L; Li C; Chen L; Neochoritis CG; Liao GP; Zhou H; Dömling A; Moroni A; Wang W
    ChemMedChem; 2015 Nov; 10(11):1837-45. PubMed ID: 26506405
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Influenza A viruses of swine circulating in the United States during 2009-2014 are susceptible to neuraminidase inhibitors but show lineage-dependent resistance to adamantanes.
    Baranovich T; Bahl J; Marathe BM; Culhane M; Stigger-Rosser E; Darnell D; Kaplan BS; Lowe JF; Webby RJ; Govorkova EA
    Antiviral Res; 2015 May; 117():10-9. PubMed ID: 25701593
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel.
    Li F; Ma C; Hu Y; Wang Y; Wang J
    ACS Infect Dis; 2016 Oct; 2(10):726-733. PubMed ID: 27657178
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers.
    Ma C; Zhang J; Wang J
    Mol Pharmacol; 2016 Sep; 90(3):188-98. PubMed ID: 27385729
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid-State NMR.
    Stampolaki Μ; Hoffmann A; Tekwani K; Georgiou K; Tzitzoglaki C; Ma C; Becker S; Schmerer P; Döring K; Stylianakis I; Turcu AL; Wang J; Vázquez S; Andreas LB; Schmidtke M; Kolocouris A
    ChemMedChem; 2023 Aug; 18(16):e202300182. PubMed ID: 37377066
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.
    Duque MD; Ma C; Torres E; Wang J; Naesens L; Juárez-Jiménez J; Camps P; Luque FJ; DeGrado WF; Lamb RA; Pinto LH; Vázquez S
    J Med Chem; 2011 Apr; 54(8):2646-57. PubMed ID: 21466220
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence.
    Durrant MG; Eggett DL; Busath DD
    BMC Genet; 2015; 16 Suppl 2(Suppl 2):S3. PubMed ID: 25953496
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.
    Wu Y; Canturk B; Jo H; Ma C; Gianti E; Klein ML; Pinto LH; Lamb RA; Fiorin G; Wang J; DeGrado WF
    J Am Chem Soc; 2014 Dec; 136(52):17987-95. PubMed ID: 25470189
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel spirothiazamenthane inhibitors of the influenza A M2 proton channel.
    Arns S; Balgi AD; Shimizu Y; Pfeifer TA; Kumar N; Shidmoossavee FS; Sun S; Tai SS; Agafitei O; Jaquith JB; Bourque E; Niikura M; Roberge M
    Eur J Med Chem; 2016 Sep; 120():64-73. PubMed ID: 27187859
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Virtual screening and molecular growth guide the design of inhibitors for the influenza virus drug-resistant mutant M2-V27A/S31N.
    Deng C; Wang X; Wang T; Liu W; Yuan X; Huang Y; Cao S
    J Biomol Struct Dyn; 2024 Jul; 42(10):5253-5267. PubMed ID: 37424098
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations.
    Abed Y; Goyette N; Boivin G
    Antimicrob Agents Chemother; 2005 Feb; 49(2):556-9. PubMed ID: 15673732
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.