180 related articles for article (PubMed ID: 28442369)
1. Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABA
Witkin JM; Cerne R; Wakulchik M; S J; Gleason SD; Jones TM; Li G; Arnold LA; Li JX; Schkeryantz JM; Methuku KR; Cook JM; Poe MM
Pharmacol Biochem Behav; 2017 Jun; 157():35-40. PubMed ID: 28442369
[TBL] [Abstract][Full Text] [Related]
2. Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA
Witkin JM; Smith JL; Ping X; Gleason SD; Poe MM; Li G; Jin X; Hobbs J; Schkeryantz JM; McDermott JS; Alatorre AI; Siemian JN; Cramer JW; Airey DC; Methuku KR; Tiruveedhula VVNPB; Jones TM; Crawford J; Krambis MJ; Fisher JL; Cook JM; Cerne R
Neuropharmacology; 2018 Jul; 137():332-343. PubMed ID: 29778948
[TBL] [Abstract][Full Text] [Related]
3. Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
Dias R; Sheppard WF; Fradley RL; Garrett EM; Stanley JL; Tye SJ; Goodacre S; Lincoln RJ; Cook SM; Conley R; Hallett D; Humphries AC; Thompson SA; Wafford KA; Street LJ; Castro JL; Whiting PJ; Rosahl TW; Atack JR; McKernan RM; Dawson GR; Reynolds DS
J Neurosci; 2005 Nov; 25(46):10682-8. PubMed ID: 16291941
[TBL] [Abstract][Full Text] [Related]
4. Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm.
Morris HV; Dawson GR; Reynolds DS; Atack JR; Stephens DN
Eur J Neurosci; 2006 May; 23(9):2495-504. PubMed ID: 16706856
[TBL] [Abstract][Full Text] [Related]
5. A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice.
Behlke LM; Foster RA; Liu J; Benke D; Benham RS; Nathanson AJ; Yee BK; Zeilhofer HU; Engin E; Rudolph U
Neuropsychopharmacology; 2016 Sep; 41(10):2492-501. PubMed ID: 27067130
[TBL] [Abstract][Full Text] [Related]
6. Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
Jacobsen EJ; Stelzer LS; TenBrink RE; Belonga KL; Carter DB; Im HK; Im WB; Sethy VH; Tang AH; VonVoigtlander PF; Petke JD; Zhong WZ; Mickelson JW
J Med Chem; 1999 Apr; 42(7):1123-44. PubMed ID: 10197957
[TBL] [Abstract][Full Text] [Related]
7. Abuse-related effects of subtype-selective GABA
Schwienteck KL; Li G; Poe MM; Cook JM; Banks ML; Stevens Negus S
Psychopharmacology (Berl); 2017 Jul; 234(14):2091-2101. PubMed ID: 28365836
[TBL] [Abstract][Full Text] [Related]
8. The GABAA-BZR complex as target for the development of anxiolytic drugs.
Trincavelli ML; Da Pozzo E; Daniele S; Martini C
Curr Top Med Chem; 2012; 12(4):254-69. PubMed ID: 22204488
[TBL] [Abstract][Full Text] [Related]
9. GABAA receptor subtype-selective modulators. I. α2/α3-selective agonists as non-sedating anxiolytics.
Atack JR
Curr Top Med Chem; 2011; 11(9):1176-202. PubMed ID: 21050172
[TBL] [Abstract][Full Text] [Related]
10. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
Popik P; Kostakis E; Krawczyk M; Nowak G; Szewczyk B; Krieter P; Chen Z; Russek SJ; Gibbs TT; Farb DH; Skolnick P; Lippa AS; Basile AS
J Pharmacol Exp Ther; 2006 Dec; 319(3):1244-52. PubMed ID: 16971504
[TBL] [Abstract][Full Text] [Related]
11. Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives.
Auta J; Kadriu B; Giusti P; Costa E; Guidotti A
Pharmacol Biochem Behav; 2010 Jun; 95(4):383-9. PubMed ID: 20227434
[TBL] [Abstract][Full Text] [Related]
12. The α2,3-selective potentiator of GABA
Witkin JM; Cerne R; Davis PG; Freeman KB; do Carmo JM; Rowlett JK; Methuku KR; Okun A; Gleason SD; Li X; Krambis MJ; Poe M; Li G; Schkeryantz JM; Jahan R; Yang L; Guo W; Golani LK; Anderson WH; Catlow JT; Jones TM; Porreca F; Smith JL; Knopp KL; Cook JM
Pharmacol Biochem Behav; 2019 May; 180():22-31. PubMed ID: 30825491
[TBL] [Abstract][Full Text] [Related]
13. GABAA receptor alpha2/alpha3 subtype-selective modulators as potential nonsedating anxiolytics.
Atack JR
Curr Top Behav Neurosci; 2010; 2():331-60. PubMed ID: 21309116
[TBL] [Abstract][Full Text] [Related]
14. An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA
Methuku KR; Li X; Cerne R; Gleason SD; Schkeryantz JM; Tiruveedhula VVNPB; Golani LK; Li G; Poe MM; Rahman MT; Cook JM; Fisher JL; Witkin JM
Pharmacol Biochem Behav; 2018 Jul; 170():9-13. PubMed ID: 29715490
[TBL] [Abstract][Full Text] [Related]
15. The α2,3-selective potentiators of GABA
Biggerstaff A; Kivell B; Smith JL; Mian MY; Golani LK; Rashid F; Sharmin D; Knutson DE; Cerne R; Cook JM; Witkin JM
Pharmacol Biochem Behav; 2020 Sep; 196():172996. PubMed ID: 32668266
[TBL] [Abstract][Full Text] [Related]
16. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.
Fischer BD; Licata SC; Edwankar RV; Wang ZJ; Huang S; He X; Yu J; Zhou H; Johnson EM; Cook JM; Furtmüller R; Ramerstorfer J; Sieghart W; Roth BL; Majumder S; Rowlett JK
Neuropharmacology; 2010 Dec; 59(7-8):612-8. PubMed ID: 20727364
[TBL] [Abstract][Full Text] [Related]
17. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.
Atack JR; Wafford KA; Street LJ; Dawson GR; Tye S; Van Laere K; Bormans G; Sanabria-Bohórquez SM; De Lepeleire I; de Hoon JN; Van Hecken A; Burns HD; McKernan RM; Murphy MG; Hargreaves RJ
J Psychopharmacol; 2011 Mar; 25(3):314-28. PubMed ID: 20147571
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABA
Poe MM; Methuku KR; Li G; Verma AR; Teske KA; Stafford DC; Arnold LA; Cramer JW; Jones TM; Cerne R; Krambis MJ; Witkin JM; Jambrina E; Rehman S; Ernst M; Cook JM; Schkeryantz JM
J Med Chem; 2016 Dec; 59(23):10800-10806. PubMed ID: 27933953
[TBL] [Abstract][Full Text] [Related]
19. Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression.
Lilly SM; Tietz EI
Brain Res; 2000 Nov; 882(1-2):139-48. PubMed ID: 11056193
[TBL] [Abstract][Full Text] [Related]
20. GABAA/benzodiazepine receptor complex mediates the anxiolytic-like effect of Montanoa tomentosa.
Sollozo-Dupont I; Estrada-Camarena E; Carro-Juárez M; López-Rubalcava C
J Ethnopharmacol; 2015 Mar; 162():278-86. PubMed ID: 25582489
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]