150 related articles for article (PubMed ID: 28450154)
1. Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect.
Zhang W; Zhang SL; Hu X; Tam KY
Eur J Pharm Sci; 2017 Dec; 110():93-100. PubMed ID: 28450154
[TBL] [Abstract][Full Text] [Related]
2. Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease.
Naia L; Cunha-Oliveira T; Rodrigues J; Rosenstock TR; Oliveira A; Ribeiro M; Carmo C; Oliveira-Sousa SI; Duarte AI; Hayden MR; Rego AC
J Neurosci; 2017 Mar; 37(10):2776-2794. PubMed ID: 28123081
[TBL] [Abstract][Full Text] [Related]
3. Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity.
Kwak CH; Jin L; Han JH; Han CW; Kim E; Cho M; Chung TW; Bae SJ; Jang SB; Ha KT
Int J Mol Sci; 2020 Aug; 21(17):. PubMed ID: 32825675
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells.
Zhang SL; Zhang W; Yang Z; Hu X; Tam KY
Eur J Pharm Sci; 2017 Dec; 110():87-92. PubMed ID: 28347773
[TBL] [Abstract][Full Text] [Related]
5. A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells.
Kawano Y; Sasano T; Arima Y; Kushima S; Tsujita K; Matsuoka M; Hata H
Biochem Biophys Res Commun; 2022 Jan; 587():153-159. PubMed ID: 34875534
[TBL] [Abstract][Full Text] [Related]
6. Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics.
Zhang W; Hu X; Chakravarty H; Yang Z; Tam KY
ACS Comb Sci; 2018 Nov; 20(11):660-671. PubMed ID: 30350563
[TBL] [Abstract][Full Text] [Related]
7. ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells.
Cesi G; Walbrecq G; Zimmer A; Kreis S; Haan C
Mol Cancer; 2017 Jun; 16(1):102. PubMed ID: 28595656
[TBL] [Abstract][Full Text] [Related]
8. Anemone rivularis inhibits pyruvate dehydrogenase kinase activity and tumor growth.
Chung TW; Lee JH; Choi HJ; Park MJ; Kim EY; Han JH; Jang SB; Lee SO; Lee SW; Hang J; Yi LW; Ha KT
J Ethnopharmacol; 2017 May; 203():47-54. PubMed ID: 28341246
[TBL] [Abstract][Full Text] [Related]
9. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships.
Zhang SL; Yang Z; Hu X; Tam KY
Bioorg Med Chem Lett; 2018 Nov; 28(21):3441-3445. PubMed ID: 30266541
[TBL] [Abstract][Full Text] [Related]
10. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
Kaplon J; Zheng L; Meissl K; Chaneton B; Selivanov VA; Mackay G; van der Burg SH; Verdegaal EM; Cascante M; Shlomi T; Gottlieb E; Peeper DS
Nature; 2013 Jun; 498(7452):109-12. PubMed ID: 23685455
[TBL] [Abstract][Full Text] [Related]
11. Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity.
Fang A; Luo H; Liu L; Fan H; Zhou Y; Yao Y; Zhang Y
Bioorg Med Chem Lett; 2017 Dec; 27(24):5450-5453. PubMed ID: 29150396
[TBL] [Abstract][Full Text] [Related]
12. Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.
Kinnaird A; Dromparis P; Saleme B; Gurtu V; Watson K; Paulin R; Zervopoulos S; Stenson T; Sutendra G; Pink DB; Carmine-Simmen K; Moore R; Lewis JD; Michelakis ED
Eur Urol; 2016 Apr; 69(4):734-744. PubMed ID: 26433571
[TBL] [Abstract][Full Text] [Related]
13. Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors.
Zhang W; Hu X; Zhou W; Tam KY
J Proteome Res; 2018 Sep; 17(9):3012-3021. PubMed ID: 30028142
[TBL] [Abstract][Full Text] [Related]
14. Ciprofloxacin Therapy Results in Mitigation of ATP Loss after Irradiation Combined with Wound Trauma: Preservation of Pyruvate Dehydrogenase and Inhibition of Pyruvate Dehydrogenase Kinase 1.
Swift JM; Smith JT; Kiang JG
Radiat Res; 2015 Jun; 183(6):684-92. PubMed ID: 26010714
[TBL] [Abstract][Full Text] [Related]
15. Rational design of mitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivity and antiproliferative activity.
Xu B; Yu Z; Xiang S; Li Y; Zhang SL; He Y
Eur J Med Chem; 2018 Jul; 155():275-284. PubMed ID: 29890389
[TBL] [Abstract][Full Text] [Related]
16. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification.
Sun W; Xie Z; Liu Y; Zhao D; Wu Z; Zhang D; Lv H; Tang S; Jin N; Jiang H; Tan M; Ding J; Luo C; Li J; Huang M; Geng M
Cancer Res; 2015 Nov; 75(22):4923-36. PubMed ID: 26483203
[TBL] [Abstract][Full Text] [Related]
17. Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.
Jin Y; Cai Q; Shenoy AK; Lim S; Zhang Y; Charles S; Tarrash M; Fu X; Kamarajugadda S; Trevino JG; Tan M; Lu J
Oncotarget; 2016 May; 7(18):25113-24. PubMed ID: 26848621
[TBL] [Abstract][Full Text] [Related]
18. Synthesis, cytotoxicity, apoptosis and molecular docking studies of novel phenylbutyrate derivatives as potential anticancer agents.
Mostoufi A; Baghgoli R; Fereidoonnezhad M
Comput Biol Chem; 2019 Jun; 80():128-137. PubMed ID: 30952039
[TBL] [Abstract][Full Text] [Related]
19. Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors.
Lin HY; Han HW; Sun WX; Yang YS; Tang CY; Lu GH; Qi JL; Wang XM; Yang YH
Eur J Med Chem; 2018 Jan; 144():137-150. PubMed ID: 29268130
[TBL] [Abstract][Full Text] [Related]
20. Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1.
Zhang SL; Yang Z; Hu X; Chakravarty H; Tam KY
Eur J Pharm Sci; 2018 Oct; 123():43-55. PubMed ID: 30012506
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
