171 related articles for article (PubMed ID: 28450237)
1. A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
Karlgren M; Simoff I; Backlund M; Wegler C; Keiser M; Handin N; Müller J; Lundquist P; Jareborg AC; Oswald S; Artursson P
J Pharm Sci; 2017 Sep; 106(9):2909-2913. PubMed ID: 28450237
[TBL] [Abstract][Full Text] [Related]
2. Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.
Wegler C; Gazit M; Issa K; Subramaniam S; Artursson P; Karlgren M
J Pharm Sci; 2021 Jan; 110(1):388-396. PubMed ID: 33007277
[TBL] [Abstract][Full Text] [Related]
3. Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9.
Simoff I; Karlgren M; Backlund M; Lindström AC; Gaugaz FZ; Matsson P; Artursson P
J Pharm Sci; 2016 Feb; 105(2):1017-1021. PubMed ID: 26869442
[TBL] [Abstract][Full Text] [Related]
4. Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
Chen EC; Broccatelli F; Plise E; Chen B; Liu L; Cheong J; Zhang S; Jorski J; Gaffney K; Umemoto KK; Salphati L
Mol Pharm; 2018 Nov; 15(11):5103-5113. PubMed ID: 30222362
[TBL] [Abstract][Full Text] [Related]
5. Establishment of optimized MDCK cell lines for reliable efflux transport studies.
Gartzke D; Fricker G
J Pharm Sci; 2014 Apr; 103(4):1298-304. PubMed ID: 24532159
[TBL] [Abstract][Full Text] [Related]
6. Kinetic analysis of human and canine P-glycoprotein-mediated drug transport in MDR1-MDCK cell model: approaches to reduce false-negative substrate classification.
Li J; Wang Y; Hidalgo IJ
J Pharm Sci; 2013 Sep; 102(9):3436-46. PubMed ID: 23558561
[TBL] [Abstract][Full Text] [Related]
7. Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport.
Kuteykin-Teplyakov K; Luna-Tortós C; Ambroziak K; Löscher W
Br J Pharmacol; 2010 Jul; 160(6):1453-63. PubMed ID: 20590635
[TBL] [Abstract][Full Text] [Related]
8. Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines.
Mukkavilli R; Jadhav G; Vangala S
Curr Pharm Biotechnol; 2017; 18(14):1151-1158. PubMed ID: 29521222
[TBL] [Abstract][Full Text] [Related]
9. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
Ye D; Harder A; Fang Z; Weinheimer M; Laplanche L; Mezler M
Pharm Res; 2020 Sep; 37(10):194. PubMed ID: 32918191
[TBL] [Abstract][Full Text] [Related]
10. Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).
Nies AT; Herrmann E; Brom M; Keppler D
Naunyn Schmiedebergs Arch Pharmacol; 2008 Feb; 376(6):449-61. PubMed ID: 18157518
[TBL] [Abstract][Full Text] [Related]
11. Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates.
Ozgür B; Saaby L; Langthaler K; Brodin B
Eur J Pharm Sci; 2018 Jan; 112():112-121. PubMed ID: 29146563
[TBL] [Abstract][Full Text] [Related]
12. Role of ABC and Solute Carrier Transporters in the Placental Transport of Lamivudine.
Ceckova M; Reznicek J; Ptackova Z; Cerveny L; Müller F; Kacerovsky M; Fromm MF; Glazier JD; Staud F
Antimicrob Agents Chemother; 2016 Sep; 60(9):5563-72. PubMed ID: 27401571
[TBL] [Abstract][Full Text] [Related]
13. Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.
Takeuchi T; Yoshitomi S; Higuchi T; Ikemoto K; Niwa S; Ebihara T; Katoh M; Yokoi T; Asahi S
Pharm Res; 2006 Jul; 23(7):1460-72. PubMed ID: 16779700
[TBL] [Abstract][Full Text] [Related]
14. Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.
Feng B; West M; Patel NC; Wager T; Hou X; Johnson J; Tremaine L; Liras J
J Pharm Sci; 2019 Jul; 108(7):2476-2483. PubMed ID: 30794795
[TBL] [Abstract][Full Text] [Related]
15. Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia.
Horio M; Chin KV; Currier SJ; Goldenberg S; Williams C; Pastan I; Gottesman MM; Handler J
J Biol Chem; 1989 Sep; 264(25):14880-4. PubMed ID: 2570070
[TBL] [Abstract][Full Text] [Related]
16. Isolation of MDCK cells with low expression of
Bokulić A; Padovan J; Stupin-Polančec D; Milić A
Acta Pharm; 2022 Jun; 72(2):275-288. PubMed ID: 36651516
[TBL] [Abstract][Full Text] [Related]
17. Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities.
Sato S; Tohyama K; Kosugi Y
Eur J Pharm Sci; 2020 Jan; 142():105119. PubMed ID: 31682973
[TBL] [Abstract][Full Text] [Related]
18. In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.
Bicker J; Alves G; Fortuna A; Soares-da-Silva P; Falcão A
Eur J Pharm Sci; 2018 May; 117():35-40. PubMed ID: 29428540
[TBL] [Abstract][Full Text] [Related]
19. Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases.
Gartzke D; Delzer J; Laplanche L; Uchida Y; Hoshi Y; Tachikawa M; Terasaki T; Sydor J; Fricker G
Pharm Res; 2015 Jun; 32(6):2060-71. PubMed ID: 25522789
[TBL] [Abstract][Full Text] [Related]
20. Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man.
Goh LB; Spears KJ; Yao D; Ayrton A; Morgan P; Roland Wolf C; Friedberg T
Biochem Pharmacol; 2002 Dec; 64(11):1569-78. PubMed ID: 12429346
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]