307 related articles for article (PubMed ID: 28455244)
1. GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells.
Abrego J; Gunda V; Vernucci E; Shukla SK; King RJ; Dasgupta A; Goode G; Murthy D; Yu F; Singh PK
Cancer Lett; 2017 Aug; 400():37-46. PubMed ID: 28455244
[TBL] [Abstract][Full Text] [Related]
2. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Hu T; Shukla SK; Vernucci E; He C; Wang D; King RJ; Jha K; Siddhanta K; Mullen NJ; Attri KS; Murthy D; Chaika NV; Thakur R; Mulder SE; Pacheco CG; Fu X; High RR; Yu F; Lazenby A; Steegborn C; Lan P; Mehla K; Rotili D; Chaudhary S; Valente S; Tafani M; Mai A; Auwerx J; Verdin E; Tuveson D; Singh PK
Gastroenterology; 2021 Nov; 161(5):1584-1600. PubMed ID: 34245764
[TBL] [Abstract][Full Text] [Related]
3. HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Li W; Chen C; Zhao X; Ye H; Zhao Y; Fu Z; Pan W; Zheng S; Wei L; Nong T; Li Z; Chen R
J Cell Mol Med; 2017 Nov; 21(11):2896-2908. PubMed ID: 28544376
[TBL] [Abstract][Full Text] [Related]
4. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism.
Sun W; Luan S; Qi C; Tong Q; Yan S; Li H; Zhang Y
Cell Commun Signal; 2019 Aug; 17(1):111. PubMed ID: 31470862
[TBL] [Abstract][Full Text] [Related]
5. miR-9-5p inhibits pancreatic cancer cell proliferation, invasion and glutamine metabolism by targeting GOT1.
Wang J; Wang B; Ren H; Chen W
Biochem Biophys Res Commun; 2019 Jan; 509(1):241-248. PubMed ID: 30591220
[TBL] [Abstract][Full Text] [Related]
6. Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming.
Yang Y; Zheng M; Han F; Shang L; Li M; Gu X; Li H; Chen L
J Mol Med (Berl); 2022 Apr; 100(4):599-612. PubMed ID: 35212782
[TBL] [Abstract][Full Text] [Related]
7. Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose.
Zhou X; Curbo S; Li F; Krishnan S; Karlsson A
BMC Cancer; 2018 May; 18(1):559. PubMed ID: 29751795
[TBL] [Abstract][Full Text] [Related]
8. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential.
Knudsen ES; Balaji U; Freinkman E; McCue P; Witkiewicz AK
Oncotarget; 2016 Nov; 7(48):78396-78411. PubMed ID: 27623078
[TBL] [Abstract][Full Text] [Related]
9. Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia.
Matschke J; Riffkin H; Klein D; Handrick R; Lüdemann L; Metzen E; Shlomi T; Stuschke M; Jendrossek V
Antioxid Redox Signal; 2016 Jul; 25(2):89-107. PubMed ID: 27021152
[TBL] [Abstract][Full Text] [Related]
10. Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells.
Srivastava S; Widmann S; Ho C; Nguyen D; Nguyen A; Premaratne A; Gustafsson JÅ; Lin CY
Int J Mol Sci; 2020 Dec; 21(24):. PubMed ID: 33348693
[TBL] [Abstract][Full Text] [Related]
11. Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.
Wang YP; Zhou W; Wang J; Huang X; Zuo Y; Wang TS; Gao X; Xu YY; Zou SW; Liu YB; Cheng JK; Lei QY
Mol Cell; 2016 Nov; 64(4):673-687. PubMed ID: 27840030
[TBL] [Abstract][Full Text] [Related]
12. Identification of distinct slow mode of reversible adaptation of pancreatic ductal adenocarcinoma to the prolonged acidic pH microenvironment.
Wu TC; Liao CY; Lu WC; Chang CR; Tsai FY; Jiang SS; Chen TH; Lin KM; Chen LT; Chang WW
J Exp Clin Cancer Res; 2022 Apr; 41(1):137. PubMed ID: 35410237
[TBL] [Abstract][Full Text] [Related]
13. Discovery of GOT1 Inhibitors from a Marine-Derived
Yan S; Qi C; Song W; Xu Q; Gu L; Sun W; Zhang Y
Mar Drugs; 2021 Oct; 19(11):. PubMed ID: 34822459
[TBL] [Abstract][Full Text] [Related]
14. Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport.
Nagarajan A; Dogra SK; Sun L; Gandotra N; Ho T; Cai G; Cline G; Kumar P; Cowles RA; Wajapeyee N
Mol Cell; 2017 Aug; 67(4):685-701.e6. PubMed ID: 28803777
[TBL] [Abstract][Full Text] [Related]
15. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Son J; Lyssiotis CA; Ying H; Wang X; Hua S; Ligorio M; Perera RM; Ferrone CR; Mullarky E; Shyh-Chang N; Kang Y; Fleming JB; Bardeesy N; Asara JM; Haigis MC; DePinho RA; Cantley LC; Kimmelman AC
Nature; 2013 Apr; 496(7443):101-5. PubMed ID: 23535601
[TBL] [Abstract][Full Text] [Related]
16. A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth.
Yoshida T; Yamasaki S; Kaneko O; Taoka N; Tomimoto Y; Namatame I; Yahata T; Kuromitsu S; Cantley LC; Lyssiotis CA
Biochem Biophys Res Commun; 2020 Feb; 522(3):633-638. PubMed ID: 31787239
[TBL] [Abstract][Full Text] [Related]
17. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Holt MC; Assar Z; Beheshti Zavareh R; Lin L; Anglin J; Mashadova O; Haldar D; Mullarky E; Kremer DM; Cantley LC; Kimmelman AC; Stein AJ; Lairson LL; Lyssiotis CA
Biochemistry; 2018 Nov; 57(47):6604-6614. PubMed ID: 30365304
[TBL] [Abstract][Full Text] [Related]
18. KRAS: feeding pancreatic cancer proliferation.
Bryant KL; Mancias JD; Kimmelman AC; Der CJ
Trends Biochem Sci; 2014 Feb; 39(2):91-100. PubMed ID: 24388967
[TBL] [Abstract][Full Text] [Related]
19. Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation.
Corbet C; Pinto A; Martherus R; Santiago de Jesus JP; Polet F; Feron O
Cell Metab; 2016 Aug; 24(2):311-23. PubMed ID: 27508876
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of GOT1 sensitizes colorectal cancer cells to 5-fluorouracil.
Hong C; Zheng J; Li X
Cancer Chemother Pharmacol; 2017 Apr; 79(4):835-840. PubMed ID: 28314989
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
