281 related articles for article (PubMed ID: 28455513)
1. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
Al-Baghdadi RJT; Nikonorova IA; Mirek ET; Wang Y; Park J; Belden WJ; Wek RC; Anthony TG
Sci Rep; 2017 Apr; 7(1):1272. PubMed ID: 28455513
[TBL] [Abstract][Full Text] [Related]
2. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
Nikonorova IA; Al-Baghdadi RJT; Mirek ET; Wang Y; Goudie MP; Wetstein BB; Dixon JL; Hine C; Mitchell JR; Adams CM; Wek RC; Anthony TG
J Biol Chem; 2017 Apr; 292(16):6786-6798. PubMed ID: 28242759
[TBL] [Abstract][Full Text] [Related]
3. Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
Nikonorova IA; Mirek ET; Signore CC; Goudie MP; Wek RC; Anthony TG
J Biol Chem; 2018 Apr; 293(14):5005-5015. PubMed ID: 29449374
[TBL] [Abstract][Full Text] [Related]
4. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.
Bunpo P; Dudley A; Cundiff JK; Cavener DR; Wek RC; Anthony TG
J Biol Chem; 2009 Nov; 284(47):32742-9. PubMed ID: 19783659
[TBL] [Abstract][Full Text] [Related]
5. The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.
Wilson GJ; Bunpo P; Cundiff JK; Wek RC; Anthony TG
Am J Physiol Endocrinol Metab; 2013 Nov; 305(9):E1124-33. PubMed ID: 24002574
[TBL] [Abstract][Full Text] [Related]
6. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.
Wilson GJ; Lennox BA; She P; Mirek ET; Al Baghdadi RJ; Fusakio ME; Dixon JL; Henderson GC; Wek RC; Anthony TG
Am J Physiol Endocrinol Metab; 2015 Feb; 308(4):E283-93. PubMed ID: 25491724
[TBL] [Abstract][Full Text] [Related]
7. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
Farooq Z; Kusuma F; Burke P; Dufour CR; Lee D; Tabatabaei N; Toboz P; Radovani E; Greenblatt JF; Rehman J; Class J; Khoutorsky A; Fonseca BD; Richner JM; Mercier E; Bourque G; Giguère V; Subramaniam AR; Han J; Tahmasebi S
J Biol Chem; 2022 Sep; 298(9):102277. PubMed ID: 35863436
[TBL] [Abstract][Full Text] [Related]
8. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
Averous J; Lambert-Langlais S; Mesclon F; Carraro V; Parry L; Jousse C; Bruhat A; Maurin AC; Pierre P; Proud CG; Fafournoux P
Sci Rep; 2016 Jun; 6():27698. PubMed ID: 27297692
[TBL] [Abstract][Full Text] [Related]
9. GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells.
Mazor KM; Stipanuk MH
Amino Acids; 2016 Dec; 48(12):2831-2842. PubMed ID: 27613409
[TBL] [Abstract][Full Text] [Related]
10. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Ye J; Palm W; Peng M; King B; Lindsten T; Li MO; Koumenis C; Thompson CB
Genes Dev; 2015 Nov; 29(22):2331-6. PubMed ID: 26543160
[TBL] [Abstract][Full Text] [Related]
11. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Byles V; Cormerais Y; Kalafut K; Barrera V; Hughes Hallett JE; Sui SH; Asara JM; Adams CM; Hoxhaj G; Ben-Sahra I; Manning BD
Mol Metab; 2021 Nov; 53():101309. PubMed ID: 34303878
[TBL] [Abstract][Full Text] [Related]
12. Amino acid restriction induces a long non-coding RNA UBA6-AS1 to regulate GCN2-mediated integrated stress response in breast cancer.
Wu YZ; Chen YH; Cheng CT; Ann DK; Kuo CY
FASEB J; 2022 Mar; 36(3):e22201. PubMed ID: 35137449
[TBL] [Abstract][Full Text] [Related]
13. General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.
Phillipson-Weiner L; Mirek ET; Wang Y; McAuliffe WG; Wek RC; Anthony TG
Am J Physiol Gastrointest Liver Physiol; 2016 Jun; 310(11):G1061-70. PubMed ID: 26968207
[TBL] [Abstract][Full Text] [Related]
14. Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes.
Griffiths A; Wang J; Song Q; Iyamu ID; Liu L; Park J; Jiang Y; Huang R; Song Z
Am J Physiol Cell Physiol; 2021 Sep; 321(3):C585-C595. PubMed ID: 34378991
[TBL] [Abstract][Full Text] [Related]
15. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
Torrence ME; MacArthur MR; Hosios AM; Valvezan AJ; Asara JM; Mitchell JR; Manning BD
Elife; 2021 Mar; 10():. PubMed ID: 33646118
[TBL] [Abstract][Full Text] [Related]
16. GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.
Kato Y; Kunimasa K; Takahashi M; Harada A; Nagasawa I; Osawa M; Sugimoto Y; Tomida A
Mol Pharmacol; 2020 Dec; 98(6):669-676. PubMed ID: 33033108
[TBL] [Abstract][Full Text] [Related]
17. BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.
Nagasawa I; Kunimasa K; Tsukahara S; Tomida A
Biochem Biophys Res Commun; 2017 Jan; 482(4):1491-1497. PubMed ID: 27965097
[TBL] [Abstract][Full Text] [Related]
18. HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection.
Jiang G; Santos Rocha C; Hirao LA; Mendes EA; Tang Y; Thompson GR; Wong JK; Dandekar S
mBio; 2017 May; 8(3):. PubMed ID: 28465428
[TBL] [Abstract][Full Text] [Related]
19. Age modulates liver responses to asparaginase-induced amino acid stress in mice.
Nikonorova IA; Zhu Q; Signore CC; Mirek ET; Jonsson WO; Kong B; Guo GL; Belden WJ; Anthony TG
J Biol Chem; 2019 Sep; 294(38):13864-13875. PubMed ID: 31413113
[TBL] [Abstract][Full Text] [Related]
20. A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling.
Brüggenthies JB; Fiore A; Russier M; Bitsina C; Brötzmann J; Kordes S; Menninger S; Wolf A; Conti E; Eickhoff JE; Murray PJ
J Biol Chem; 2022 Dec; 298(12):102629. PubMed ID: 36273589
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]