225 related articles for article (PubMed ID: 28455519)
1. Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes.
Chiarini A; Armato U; Liu D; Dal Prà I
Sci Rep; 2017 Apr; 7(1):1277. PubMed ID: 28455519
[TBL] [Abstract][Full Text] [Related]
2. Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.
Armato U; Chiarini A; Chakravarthy B; Chioffi F; Pacchiana R; Colarusso E; Whitfield JF; Dal Prà I
Biochim Biophys Acta; 2013 Oct; 1832(10):1634-52. PubMed ID: 23628734
[TBL] [Abstract][Full Text] [Related]
3. Targeting Human Astrocytes' Calcium-sensing Receptors for Treatment of Alzheimer's Disease.
Chiarini A; Armato U; Whitfield JF; Pra ID
Curr Pharm Des; 2017; 23(33):4990-5000. PubMed ID: 28699522
[TBL] [Abstract][Full Text] [Related]
4. CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes.
Chiarini A; Armato U; Hu P; Dal Prà I
Cells; 2020 Jun; 9(6):. PubMed ID: 32498476
[TBL] [Abstract][Full Text] [Related]
5. Preventing the spread of Alzheimer's disease neuropathology: a role for calcilytics?
Chiarini A; Gardenal E; Whitfield JF; Chakravarthy B; Armato U; Dal Pra I
Curr Pharm Biotechnol; 2015; 16(8):696-706. PubMed ID: 25941885
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.
Shackleton B; Crawford F; Bachmeier C
Fluids Barriers CNS; 2016 Aug; 13(1):14. PubMed ID: 27503326
[TBL] [Abstract][Full Text] [Related]
7. The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.
Zhao J; O'Connor T; Vassar R
J Neuroinflammation; 2011 Nov; 8():150. PubMed ID: 22047170
[TBL] [Abstract][Full Text] [Related]
8. Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease.
Chiarini A; Armato U; Liu D; Dal Prà I
Front Physiol; 2016; 7():134. PubMed ID: 27199760
[TBL] [Abstract][Full Text] [Related]
9. The Aβ peptides-activated calcium-sensing receptor stimulates the production and secretion of vascular endothelial growth factor-A by normoxic adult human cortical astrocytes.
Dal Prà I; Armato U; Chioffi F; Pacchiana R; Whitfield JF; Chakravarthy B; Gui L; Chiarini A
Neuromolecular Med; 2014 Dec; 16(4):645-57. PubMed ID: 24948534
[TBL] [Abstract][Full Text] [Related]
10. Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.
Wang XF; Liu DX; Liang Y; Xing LL; Zhao WH; Qin XX; Shang DS; Li B; Fang WG; Cao L; Zhao WD; Chen YH
PLoS One; 2016; 11(8):e0161093. PubMed ID: 27532339
[TBL] [Abstract][Full Text] [Related]
11. Different Expression Patterns of Amyloid-β Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-β Pathogenesis.
Xu ZQ; Huang H; Chen YL; Gao YY; Xu J; Marshall C; Cai ZY; Xiao M
J Alzheimers Dis; 2016; 51(1):179-95. PubMed ID: 26836155
[TBL] [Abstract][Full Text] [Related]
12. Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143-Further Implications for Alzheimer's Therapy.
Chiarini A; Armato U; Gardenal E; Gui L; Dal Prà I
Front Neurosci; 2017; 11():217. PubMed ID: 28473749
[TBL] [Abstract][Full Text] [Related]
13. Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage.
Durand D; Carniglia L; Beauquis J; Caruso C; Saravia F; Lasaga M
Neuropharmacology; 2014 Apr; 79():180-9. PubMed ID: 24291464
[TBL] [Abstract][Full Text] [Related]
14. Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease.
Al-Atrache Z; Lopez DB; Hingley ST; Appelt DM
BMC Neurosci; 2019 Feb; 20(1):6. PubMed ID: 30786875
[TBL] [Abstract][Full Text] [Related]
15. Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes.
Yang H; Wang Y; Kar S
Glia; 2017 Nov; 65(11):1728-1743. PubMed ID: 28722194
[TBL] [Abstract][Full Text] [Related]
16. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase.
Jung CG; Uhm KO; Horike H; Kim MJ; Misumi S; Ishida A; Ueda Y; Choi EK; Kim YS; Michikawa M; Hida H
J Alzheimers Dis; 2015; 43(4):1215-28. PubMed ID: 25147119
[TBL] [Abstract][Full Text] [Related]
17. Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density.
Zhang C; Browne A; Divito JR; Stevenson JA; Romano D; Dong Y; Xie Z; Tanzi RE
J Alzheimers Dis; 2010; 22(2):683-984. PubMed ID: 20847415
[TBL] [Abstract][Full Text] [Related]
18. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.
Cam M; Durieu E; Bodin M; Manousopoulou A; Koslowski S; Vasylieva N; Barnych B; Hammock BD; Bohl B; Koch P; Omori C; Yamamoto K; Hata S; Suzuki T; Karg F; Gizzi P; Erakovic Haber V; Bencetic Mihaljevic V; Tavcar B; Portelius E; Pannee J; Blennow K; Zetterberg H; Garbis SD; Auvray P; Gerber H; Fraering J; Fraering PC; Meijer L
J Alzheimers Dis; 2018; 62(4):1663-1681. PubMed ID: 29504531
[TBL] [Abstract][Full Text] [Related]
19. C6 Glioma-Secreted NGF and FGF2 Regulate Neuronal APP Processing Through Up-Regulation of ADAM10 and Down-Regulation of BACE1, Respectively.
Xie H; Xiao Z; Huang J
J Mol Neurosci; 2016 Jul; 59(3):334-42. PubMed ID: 26614345
[TBL] [Abstract][Full Text] [Related]
20. Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-α.
Durairajan SS; Liu LF; Lu JH; Koo I; Maruyama K; Chung SK; Huang JD; Li M
J Alzheimers Dis; 2011; 25(2):245-62. PubMed ID: 21403388
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]