BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 28460359)

  • 1. Synthesis and biological evaluation of benzimidazole derivatives as the G9a Histone Methyltransferase inhibitors that induce autophagy and apoptosis of breast cancer cells.
    Zhang J; Yao D; Jiang Y; Huang J; Yang S; Wang J
    Bioorg Chem; 2017 Jun; 72():168-181. PubMed ID: 28460359
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification.
    Chen WL; Wang ZH; Feng TT; Li DD; Wang CH; Xu XL; Zhang XJ; You QD; Guo XK
    Bioorg Med Chem; 2016 Nov; 24(22):6102-6108. PubMed ID: 27720557
    [TBL] [Abstract][Full Text] [Related]  

  • 3. G9a - An Appealing Antineoplastic Target.
    Chen WL; Sun HP; Li DD; Wang ZH; You QD; Guo XK
    Curr Cancer Drug Targets; 2017; 17(6):555-568. PubMed ID: 27174055
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Recent progress in histone methyltransferase (G9a) inhibitors as anticancer agents.
    Cao H; Li L; Yang D; Zeng L; Yewei X; Yu B; Liao G; Chen J
    Eur J Med Chem; 2019 Oct; 179():537-546. PubMed ID: 31276898
    [TBL] [Abstract][Full Text] [Related]  

  • 5. BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production.
    Kim Y; Kim YS; Kim DE; Lee JS; Song JH; Kim HG; Cho DH; Jeong SY; Jin DH; Jang SJ; Seol HS; Suh YA; Lee SJ; Kim CS; Koh JY; Hwang JJ
    Autophagy; 2013 Dec; 9(12):2126-39. PubMed ID: 24322755
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Targeting EHMT2/ G9a for cancer therapy: Progress and perspective.
    Jan S; Dar MI; Wani R; Sandey J; Mushtaq I; Lateef S; Syed SH
    Eur J Pharmacol; 2021 Feb; 893():173827. PubMed ID: 33347828
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Insights for the design of protein lysine methyltransferase G9a inhibitors.
    Charles MRC; Dhayalan A; Hsieh HP; Coumar MS
    Future Med Chem; 2019 May; 11(9):993-1014. PubMed ID: 31141392
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
    Liu F; Barsyte-Lovejoy D; Li F; Xiong Y; Korboukh V; Huang XP; Allali-Hassani A; Janzen WP; Roth BL; Frye SV; Arrowsmith CH; Brown PJ; Vedadi M; Jin J
    J Med Chem; 2013 Nov; 56(21):8931-42. PubMed ID: 24102134
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma.
    Ren A; Qiu Y; Cui H; Fu G
    Biochem Biophys Res Commun; 2015 Mar; 459(1):10-7. PubMed ID: 25634693
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.
    Katayama K; Ishii K; Tsuda E; Yotsumoto K; Hiramoto K; Suzuki M; Yasumatsu I; Igarashi W; Torihata M; Ishiyama T; Katagiri T
    Bioorg Med Chem Lett; 2020 Oct; 30(20):127475. PubMed ID: 32781218
    [TBL] [Abstract][Full Text] [Related]  

  • 11. G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma.
    Li F; Zeng J; Gao Y; Guan Z; Ma Z; Shi Q; Du C; Jia J; Xu S; Wang X; Chang L; He D; Guo P
    PLoS One; 2015; 10(9):e0138390. PubMed ID: 26397365
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search.
    Ding H; Lu WC; Hu JC; Liu YC; Zhang CH; Lian FL; Zhang NX; Meng FW; Luo C; Chen KX
    Molecules; 2018 Mar; 23(3):. PubMed ID: 29498708
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening.
    Charles MRC; Mahesh A; Lin SY; Hsieh HP; Dhayalan A; Coumar MS
    Biochimie; 2020 Jan; 168():220-230. PubMed ID: 31756401
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II).
    Lenstra DC; Al Temimi AHK; Mecinović J
    Bioorg Med Chem Lett; 2018 Apr; 28(7):1234-1238. PubMed ID: 29519735
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.
    Yoon YK; Ali MA; Wei AC; Choon TS; Osman H; Parang K; Shirazi AN
    Bioorg Med Chem; 2014 Jan; 22(2):703-10. PubMed ID: 24387981
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.
    Yuan Y; Wang Q; Paulk J; Kubicek S; Kemp MM; Adams DJ; Shamji AF; Wagner BK; Schreiber SL
    ACS Chem Biol; 2012 Jul; 7(7):1152-7. PubMed ID: 22536950
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer.
    Nashaat S; Henen MA; El-Messery SM; Eisa H
    Bioorg Med Chem; 2020 Jun; 28(11):115495. PubMed ID: 32307260
    [TBL] [Abstract][Full Text] [Related]  

  • 18. G9a promotes cell proliferation and suppresses autophagy in gastric cancer by directly activating mTOR.
    Yin C; Ke X; Zhang R; Hou J; Dong Z; Wang F; Zhang K; Zhong X; Yang L; Cui H
    FASEB J; 2019 Dec; 33(12):14036-14050. PubMed ID: 31647887
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis and structure-activity relationship of a focused library of β-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer.
    Guo Y; Zhao Y; Wang G; Chen Y; Jiang Y; Ouyang L; Liu B
    Eur J Med Chem; 2018 Jan; 143():402-418. PubMed ID: 29202403
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells.
    Cao YP; Sun JY; Li MQ; Dong Y; Zhang YH; Yan J; Huang RM; Yan X
    Acta Pharmacol Sin; 2019 Aug; 40(8):1076-1084. PubMed ID: 30765842
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.