295 related articles for article (PubMed ID: 28462395)
1. Calmodulin and PI3K Signaling in
Nussinov R; Wang G; Tsai CJ; Jang H; Lu S; Banerjee A; Zhang J; Gaponenko V
Trends Cancer; 2017 Mar; 3(3):214-224. PubMed ID: 28462395
[TBL] [Abstract][Full Text] [Related]
2. Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.
Nussinov R; Zhang M; Tsai CJ; Jang H
Biochim Biophys Acta Mol Basis Dis; 2018 Jun; 1864(6 Pt B):2304-2314. PubMed ID: 29097261
[TBL] [Abstract][Full Text] [Related]
3. Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
Jang H; Banerjee A; Chavan T; Gaponenko V; Nussinov R
J Biol Chem; 2017 Jul; 292(30):12544-12559. PubMed ID: 28623230
[TBL] [Abstract][Full Text] [Related]
4. Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH
Zhang M; Jang H; Gaponenko V; Nussinov R
Biophys J; 2017 Nov; 113(9):1956-1967. PubMed ID: 29117520
[TBL] [Abstract][Full Text] [Related]
5. The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.
Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
Mol Cancer Res; 2015 Sep; 13(9):1265-73. PubMed ID: 26085527
[TBL] [Abstract][Full Text] [Related]
6. Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?
Nussinov R; Tsai CJ; Jang H
Semin Cancer Biol; 2019 Feb; 54():114-120. PubMed ID: 29307569
[TBL] [Abstract][Full Text] [Related]
7. Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.
Wang G; Zhang M; Jang H; Lu S; Lin S; Chen G; Nussinov R; Zhang J; Gaponenko V
Biochemistry; 2018 Mar; 57(12):1917-1928. PubMed ID: 29494137
[TBL] [Abstract][Full Text] [Related]
8. K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?
Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
Expert Opin Ther Targets; 2016 Jul; 20(7):831-42. PubMed ID: 26873344
[TBL] [Abstract][Full Text] [Related]
9. Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α.
Zhang M; Li Z; Wang G; Jang H; Sacks DB; Zhang J; Gaponenko V; Nussinov R
J Phys Chem B; 2018 Dec; 122(49):11137-11146. PubMed ID: 30047727
[TBL] [Abstract][Full Text] [Related]
10. The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations.
Abdelkarim H; Leschinsky N; Jang H; Banerjee A; Nussinov R; Gaponenko V
Curr Opin Struct Biol; 2021 Dec; 71():164-170. PubMed ID: 34311289
[TBL] [Abstract][Full Text] [Related]
11. The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin.
Jang H; Banerjee A; Marcus K; Makowski L; Mattos C; Gaponenko V; Nussinov R
Structure; 2019 Nov; 27(11):1647-1659.e4. PubMed ID: 31495533
[TBL] [Abstract][Full Text] [Related]
12. Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin.
Ni D; Liu D; Zhang J; Lu S
Int J Mol Sci; 2018 Jan; 19(1):. PubMed ID: 29300353
[TBL] [Abstract][Full Text] [Related]
13. Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulin.
Wu LJ; Xu LR; Liao JM; Chen J; Liang Y
PLoS One; 2011; 6(7):e21929. PubMed ID: 21750741
[TBL] [Abstract][Full Text] [Related]
14. v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras.
Akagi T; Murata K; Shishido T; Hanafusa H
Mol Cell Biol; 2002 Oct; 22(20):7015-23. PubMed ID: 12242282
[TBL] [Abstract][Full Text] [Related]
15. Oncogenic Ras Isoforms Signaling Specificity at the Membrane.
Nussinov R; Tsai CJ; Jang H
Cancer Res; 2018 Feb; 78(3):593-602. PubMed ID: 29273632
[TBL] [Abstract][Full Text] [Related]
16. Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b.
Adapala NS; Barbe MF; Tsygankov AY; Lorenzo JA; Sanjay A
J Cell Biochem; 2014 Jul; 115(7):1277-89. PubMed ID: 24470255
[TBL] [Abstract][Full Text] [Related]
17. Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
Li X; Dai J; Ni D; He X; Zhang H; Zhang J; Fu Q; Liu Y; Lu S
Int J Biol Macromol; 2020 Feb; 144():643-655. PubMed ID: 31816384
[TBL] [Abstract][Full Text] [Related]
18. The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin.
Abraham SJ; Nolet RP; Calvert RJ; Anderson LM; Gaponenko V
Biochemistry; 2009 Aug; 48(32):7575-83. PubMed ID: 19583261
[TBL] [Abstract][Full Text] [Related]
19. The structural basis of Akt PH domain interaction with calmodulin.
Weako J; Jang H; Keskin O; Nussinov R; Gursoy A
Biophys J; 2021 May; 120(10):1994-2008. PubMed ID: 33775637
[TBL] [Abstract][Full Text] [Related]
20. K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function.
Alvarez-Moya B; López-Alcalá C; Drosten M; Bachs O; Agell N
Oncogene; 2010 Nov; 29(44):5911-22. PubMed ID: 20802526
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]