BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

244 related articles for article (PubMed ID: 28481250)

  • 1. 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC Inhibitors.
    Zuo K; Liang L; Du W; Sun X; Liu W; Gou X; Wan H; Hu J
    Int J Mol Sci; 2017 May; 18(5):. PubMed ID: 28481250
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The inhibitory and binding studies of methyl-sulfone hydroxamate based inhibitors against LpxC from drug resistant Moraxella catarrhalis using biophysical, biochemical and in silico approaches.
    Sharma A; Kumar V; Pratap S; Kumar P
    Int J Biol Macromol; 2018 Oct; 118(Pt B):1747-1762. PubMed ID: 30017978
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors.
    Kadam RU; Roy N
    Bioorg Med Chem Lett; 2006 Oct; 16(19):5136-43. PubMed ID: 16879960
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.
    Szermerski M; Melesina J; Wichapong K; Löppenberg M; Jose J; Sippl W; Holl R
    Bioorg Med Chem; 2014 Feb; 22(3):1016-28. PubMed ID: 24412340
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors.
    Basak S; Li Y; Tao S; Daryaee F; Merino J; Gu C; Delker SL; Phan JN; Edwards TE; Walker SG; Tonge PJ
    J Med Chem; 2022 Sep; 65(17):11854-11875. PubMed ID: 36037447
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential.
    Kadam RU; Garg D; Roy N
    Chem Biol Drug Des; 2008 Jan; 71(1):45-56. PubMed ID: 18086152
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
    Warmus JS; Quinn CL; Taylor C; Murphy ST; Johnson TA; Limberakis C; Ortwine D; Bronstein J; Pagano P; Knafels JD; Lightle S; Mochalkin I; Brideau R; Podoll T
    Bioorg Med Chem Lett; 2012 Apr; 22(7):2536-43. PubMed ID: 22401863
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacophoric features of Pseudomonas aeruginosa deacetylase LpxC inhibitors: an electronic and structural analysis.
    Kadam RU; Chavan A; Roy N
    Bioorg Med Chem Lett; 2007 Feb; 17(4):861-8. PubMed ID: 17188864
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Subtractive Genomics, Molecular Docking and Molecular Dynamics Simulation Revealed LpxC as a Potential Drug Target Against Multi-Drug Resistant Klebsiella pneumoniae.
    Ahmad S; Navid A; Akhtar AS; Azam SS; Wadood A; Pérez-Sánchez H
    Interdiscip Sci; 2019 Sep; 11(3):508-526. PubMed ID: 29721784
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 .
    Cole KE; Gattis SG; Angell HD; Fierke CA; Christianson DW
    Biochemistry; 2011 Jan; 50(2):258-65. PubMed ID: 21171638
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.
    McAllister LA; Montgomery JI; Abramite JA; Reilly U; Brown MF; Chen JM; Barham RA; Che Y; Chung SW; Menard CA; Mitton-Fry M; Mullins LM; Noe MC; O'Donnell JP; Oliver RM; Penzien JB; Plummer M; Price LM; Shanmugasundaram V; Tomaras AP; Uccello DP
    Bioorg Med Chem Lett; 2012 Nov; 22(22):6832-8. PubMed ID: 23046961
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
    Mochalkin I; Knafels JD; Lightle S
    Protein Sci; 2008 Mar; 17(3):450-7. PubMed ID: 18287278
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNFalpha inhibitors: a multiscreening approach.
    Kadam RU; Garg D; Chavan A; Roy N
    J Chem Inf Model; 2007; 47(3):1188-95. PubMed ID: 17458951
    [TBL] [Abstract][Full Text] [Related]  

  • 14. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) inhibitors: a new class of antibacterial agents.
    Zhang J; Zhang L; Li X; Xu W
    Curr Med Chem; 2012; 19(13):2038-50. PubMed ID: 22414079
    [TBL] [Abstract][Full Text] [Related]  

  • 15. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.
    Jackman JE; Raetz CR; Fierke CA
    Biochemistry; 1999 Feb; 38(6):1902-11. PubMed ID: 10026271
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.
    Jackman JE; Fierke CA; Tumey LN; Pirrung M; Uchiyama T; Tahir SH; Hindsgaul O; Raetz CR
    J Biol Chem; 2000 Apr; 275(15):11002-9. PubMed ID: 10753902
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Exploring the UDP pocket of LpxC through amino acid analogs.
    Hale MR; Hill P; Lahiri S; Miller MD; Ross P; Alm R; Gao N; Kutschke A; Johnstone M; Prince B; Thresher J; Yang W
    Bioorg Med Chem Lett; 2013 Apr; 23(8):2362-7. PubMed ID: 23499237
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
    Piizzi G; Parker DT; Peng Y; Dobler M; Patnaik A; Wattanasin S; Liu E; Lenoir F; Nunez J; Kerrigan J; McKenney D; Osborne C; Yu D; Lanieri L; Bojkovic J; Dzink-Fox J; Lilly MD; Sprague ER; Lu Y; Wang H; Ranjitkar S; Xie L; Wang B; Glick M; Hamann LG; Tommasi R; Yang X; Dean CR
    J Med Chem; 2017 Jun; 60(12):5002-5014. PubMed ID: 28549219
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC of Leptospira spp.: homology modeling, docking, and molecular dynamics study.
    Pradhan D; Priyadarshini V; Munikumar M; Swargam S; Umamaheswari A; Bitla A
    J Biomol Struct Dyn; 2014; 32(2):171-85. PubMed ID: 23383626
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.
    Mdluli KE; Witte PR; Kline T; Barb AW; Erwin AL; Mansfield BE; McClerren AL; Pirrung MC; Tumey LN; Warrener P; Raetz CR; Stover CK
    Antimicrob Agents Chemother; 2006 Jun; 50(6):2178-84. PubMed ID: 16723580
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.