278 related articles for article (PubMed ID: 28483956)
1. The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.
Warrilow AGS; Parker JE; Price CL; Garvey EP; Hoekstra WJ; Schotzinger RJ; Wiederhold NP; Nes WD; Kelly DE; Kelly SL
Antimicrob Agents Chemother; 2017 Jul; 61(7):. PubMed ID: 28483956
[TBL] [Abstract][Full Text] [Related]
2. Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.
Warrilow AG; Price CL; Parker JE; Rolley NJ; Smyrniotis CJ; Hughes DD; Thoss V; Nes WD; Kelly DE; Holman TR; Kelly SL
Sci Rep; 2016 Jun; 6():27690. PubMed ID: 27291783
[TBL] [Abstract][Full Text] [Related]
3. The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
Warrilow AG; Parker JE; Price CL; Nes WD; Garvey EP; Hoekstra WJ; Schotzinger RJ; Kelly DE; Kelly SL
Antimicrob Agents Chemother; 2016 Aug; 60(8):4530-8. PubMed ID: 27161631
[TBL] [Abstract][Full Text] [Related]
4. Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Hargrove TY; Garvey EP; Hoekstra WJ; Yates CM; Wawrzak Z; Rachakonda G; Villalta F; Lepesheva GI
Antimicrob Agents Chemother; 2017 Jul; 61(7):. PubMed ID: 28461309
[TBL] [Abstract][Full Text] [Related]
5. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.
Warrilow AG; Hull CM; Parker JE; Garvey EP; Hoekstra WJ; Moore WR; Schotzinger RJ; Kelly DE; Kelly SL
Antimicrob Agents Chemother; 2014 Dec; 58(12):7121-7. PubMed ID: 25224009
[TBL] [Abstract][Full Text] [Related]
6.
Nishimoto AT; Wiederhold NP; Flowers SA; Zhang Q; Kelly SL; Morschhäuser J; Yates CM; Hoekstra WJ; Schotzinger RJ; Garvey EP; Rogers PD
Antimicrob Agents Chemother; 2019 Jun; 63(6):. PubMed ID: 30910896
[TBL] [Abstract][Full Text] [Related]
7. Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51).
Warrilow AG; Hull CM; Rolley NJ; Parker JE; Nes WD; Smith SN; Kelly DE; Kelly SL
Appl Environ Microbiol; 2014 Oct; 80(19):6154-66. PubMed ID: 25085484
[TBL] [Abstract][Full Text] [Related]
8. Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51).
Lamb DC; Warrilow AG; Rolley NJ; Parker JE; Nes WD; Smith SN; Kelly DE; Kelly SL
Antimicrob Agents Chemother; 2015 Aug; 59(8):4707-13. PubMed ID: 26014948
[TBL] [Abstract][Full Text] [Related]
9. Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).
Warrilow AG; Martel CM; Parker JE; Melo N; Lamb DC; Nes WD; Kelly DE; Kelly SL
Antimicrob Agents Chemother; 2010 Oct; 54(10):4235-45. PubMed ID: 20625155
[TBL] [Abstract][Full Text] [Related]
10. The Evolution of Azole Resistance in
Warrilow AG; Nishimoto AT; Parker JE; Price CL; Flowers SA; Kelly DE; Rogers PD; Kelly SL
Antimicrob Agents Chemother; 2019 May; 63(5):. PubMed ID: 30783005
[TBL] [Abstract][Full Text] [Related]
11. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.
Warrilow AG; Melo N; Martel CM; Parker JE; Nes WD; Kelly SL; Kelly DE
Antimicrob Agents Chemother; 2010 Oct; 54(10):4225-34. PubMed ID: 20660663
[TBL] [Abstract][Full Text] [Related]
12. Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.
Monk BC; Keniya MV; Sabherwal M; Wilson RK; Graham DO; Hassan HF; Chen D; Tyndall JDA
Antimicrob Agents Chemother; 2019 Jan; 63(1):. PubMed ID: 30397057
[TBL] [Abstract][Full Text] [Related]
13. Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.
Warrilow AG; Parker JE; Kelly DE; Kelly SL
Antimicrob Agents Chemother; 2013 Mar; 57(3):1352-60. PubMed ID: 23274672
[TBL] [Abstract][Full Text] [Related]
14. Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.
Keniya MV; Ruma YN; Tyndall JDA; Monk BC
Antimicrob Agents Chemother; 2018 Nov; 62(11):. PubMed ID: 30126959
[TBL] [Abstract][Full Text] [Related]
15. Structural analyses of
Hargrove TY; Friggeri L; Wawrzak Z; Qi A; Hoekstra WJ; Schotzinger RJ; York JD; Guengerich FP; Lepesheva GI
J Biol Chem; 2017 Apr; 292(16):6728-6743. PubMed ID: 28258218
[TBL] [Abstract][Full Text] [Related]
16. Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
Sagatova AA; Keniya MV; Tyndall JDA; Monk BC
Antimicrob Agents Chemother; 2018 Mar; 62(3):. PubMed ID: 29263059
[TBL] [Abstract][Full Text] [Related]
17. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii.
Lockhart SR; Fothergill AW; Iqbal N; Bolden CB; Grossman NT; Garvey EP; Brand SR; Hoekstra WJ; Schotzinger RJ; Ottinger E; Patterson TF; Wiederhold NP
Antimicrob Agents Chemother; 2016 Apr; 60(4):2528-31. PubMed ID: 26787697
[TBL] [Abstract][Full Text] [Related]
18. Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.
Sanglard D; Coste AT
Antimicrob Agents Chemother; 2016 Jan; 60(1):229-38. PubMed ID: 26482310
[TBL] [Abstract][Full Text] [Related]
19. Antifungal susceptibility testing of Trichophyton rubrum by E-test.
da Silva Barros ME; de Assis Santos D; Soares Hamdan J
Arch Dermatol Res; 2007 May; 299(2):107-9. PubMed ID: 17333224
[TBL] [Abstract][Full Text] [Related]
20. Activity of VT-1129 against Cryptococcus neoformans clinical isolates with high fluconazole MICs.
Nielsen K; Vedula P; Smith KD; Meya DB; Garvey EP; Hoekstra WJ; Schotzinger RJ; Boulware DR
Med Mycol; 2017 Jun; 55(4):453-456. PubMed ID: 27664991
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
