700 related articles for article (PubMed ID: 28489822)
1. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
Wang B; Jie Z; Joo D; Ordureau A; Liu P; Gan W; Guo J; Zhang J; North BJ; Dai X; Cheng X; Bian X; Zhang L; Harper JW; Sun SC; Wei W
Nature; 2017 May; 545(7654):365-369. PubMed ID: 28489822
[TBL] [Abstract][Full Text] [Related]
2. Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1.
Ghomlaghi M; Yang G; Shin SY; James DE; Nguyen LK
PLoS Comput Biol; 2021 Sep; 17(9):e1008513. PubMed ID: 34529665
[TBL] [Abstract][Full Text] [Related]
3. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Liu P; Gan W; Inuzuka H; Lazorchak AS; Gao D; Arojo O; Liu D; Wan L; Zhai B; Yu Y; Yuan M; Kim BM; Shaik S; Menon S; Gygi SP; Lee TH; Asara JM; Manning BD; Blenis J; Su B; Wei W
Nat Cell Biol; 2013 Nov; 15(11):1340-50. PubMed ID: 24161930
[TBL] [Abstract][Full Text] [Related]
4. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Liu P; Gan W; Chin YR; Ogura K; Guo J; Zhang J; Wang B; Blenis J; Cantley LC; Toker A; Su B; Wei W
Cancer Discov; 2015 Nov; 5(11):1194-209. PubMed ID: 26293922
[TBL] [Abstract][Full Text] [Related]
5. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
[TBL] [Abstract][Full Text] [Related]
6. Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.
Hussain S; Feldman AL; Das C; Ziesmer SC; Ansell SM; Galardy PJ
Mol Cell Biol; 2013 Mar; 33(6):1188-97. PubMed ID: 23297343
[TBL] [Abstract][Full Text] [Related]
7. Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
Chen CH; Kiyan V; Zhylkibayev AA; Kazyken D; Bulgakova O; Page KE; Bersimbaev RI; Spooner E; Sarbassov DD
J Biol Chem; 2013 Sep; 288(38):27019-27030. PubMed ID: 23928304
[TBL] [Abstract][Full Text] [Related]
8. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
Misra UK; Pizzo SV
PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
[TBL] [Abstract][Full Text] [Related]
9. Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity.
Liu P; Guo J; Gan W; Wei W
Protein Cell; 2014 Mar; 5(3):171-7. PubMed ID: 24481632
[TBL] [Abstract][Full Text] [Related]
10. Crosstalk between mTOR complexes.
Xie J; Proud CG
Nat Cell Biol; 2013 Nov; 15(11):1263-5. PubMed ID: 24189516
[TBL] [Abstract][Full Text] [Related]
11. Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis.
Wang G; Chen L; Qin S; Zheng Y; Xia C; Yao J; Wang P; Deng L
Mol Nutr Food Res; 2022 Dec; 66(23):e2200186. PubMed ID: 36189894
[TBL] [Abstract][Full Text] [Related]
12. Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth
Hwang Y; Kim LC; Song W; Edwards DN; Cook RS; Chen J
Cancer Res; 2019 Jul; 79(13):3178-3184. PubMed ID: 31085701
[TBL] [Abstract][Full Text] [Related]
13. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
Woo SY; Kim DH; Jun CB; Kim YM; Haar EV; Lee SI; Hegg JW; Bandhakavi S; Griffin TJ; Kim DH
J Biol Chem; 2007 Aug; 282(35):25604-12. PubMed ID: 17599906
[TBL] [Abstract][Full Text] [Related]
14. Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly.
Luo Q; Chai X; Xin X; Ouyang W; Deng F
Diabetol Metab Syndr; 2023 Mar; 15(1):49. PubMed ID: 36927703
[TBL] [Abstract][Full Text] [Related]
15. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
García-Martínez JM; Alessi DR
Biochem J; 2008 Dec; 416(3):375-85. PubMed ID: 18925875
[TBL] [Abstract][Full Text] [Related]
16. Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin.
Zou Z; Chen J; Yang J; Bai X
Curr Cancer Drug Targets; 2016; 16(4):288-304. PubMed ID: 26563881
[TBL] [Abstract][Full Text] [Related]
17. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
Yang G; Murashige DS; Humphrey SJ; James DE
Cell Rep; 2015 Aug; 12(6):937-43. PubMed ID: 26235620
[TBL] [Abstract][Full Text] [Related]
18. Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation.
Chen Y; Jiao D; He H; Sun H; Liu Y; Shi Q; Zhang P; Li Y; Mo R; Gao K; Wang C
Redox Biol; 2023 Nov; 67():102872. PubMed ID: 37688978
[TBL] [Abstract][Full Text] [Related]
19. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
Kim SJ; DeStefano MA; Oh WJ; Wu CC; Vega-Cotto NM; Finlan M; Liu D; Su B; Jacinto E
Mol Cell; 2012 Dec; 48(6):875-87. PubMed ID: 23142081
[TBL] [Abstract][Full Text] [Related]
20. Disentangling the signaling pathways of mTOR complexes, mTORC1 and mTORC2, as a therapeutic target in glioblastoma.
Jhanwar-Uniyal M; Dominguez JF; Mohan AL; Tobias ME; Gandhi CD
Adv Biol Regul; 2022 Jan; 83():100854. PubMed ID: 34996736
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]