BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

700 related articles for article (PubMed ID: 28489822)

  • 1. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
    Wang B; Jie Z; Joo D; Ordureau A; Liu P; Gan W; Guo J; Zhang J; North BJ; Dai X; Cheng X; Bian X; Zhang L; Harper JW; Sun SC; Wei W
    Nature; 2017 May; 545(7654):365-369. PubMed ID: 28489822
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1.
    Ghomlaghi M; Yang G; Shin SY; James DE; Nguyen LK
    PLoS Comput Biol; 2021 Sep; 17(9):e1008513. PubMed ID: 34529665
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
    Liu P; Gan W; Inuzuka H; Lazorchak AS; Gao D; Arojo O; Liu D; Wan L; Zhai B; Yu Y; Yuan M; Kim BM; Shaik S; Menon S; Gygi SP; Lee TH; Asara JM; Manning BD; Blenis J; Su B; Wei W
    Nat Cell Biol; 2013 Nov; 15(11):1340-50. PubMed ID: 24161930
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
    Liu P; Gan W; Chin YR; Ogura K; Guo J; Zhang J; Wang B; Blenis J; Cantley LC; Toker A; Su B; Wei W
    Cancer Discov; 2015 Nov; 5(11):1194-209. PubMed ID: 26293922
    [TBL] [Abstract][Full Text] [Related]  

  • 5. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.
    Hussain S; Feldman AL; Das C; Ziesmer SC; Ansell SM; Galardy PJ
    Mol Cell Biol; 2013 Mar; 33(6):1188-97. PubMed ID: 23297343
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
    Chen CH; Kiyan V; Zhylkibayev AA; Kazyken D; Bulgakova O; Page KE; Bersimbaev RI; Spooner E; Sarbassov DD
    J Biol Chem; 2013 Sep; 288(38):27019-27030. PubMed ID: 23928304
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity.
    Liu P; Guo J; Gan W; Wei W
    Protein Cell; 2014 Mar; 5(3):171-7. PubMed ID: 24481632
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crosstalk between mTOR complexes.
    Xie J; Proud CG
    Nat Cell Biol; 2013 Nov; 15(11):1263-5. PubMed ID: 24189516
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis.
    Wang G; Chen L; Qin S; Zheng Y; Xia C; Yao J; Wang P; Deng L
    Mol Nutr Food Res; 2022 Dec; 66(23):e2200186. PubMed ID: 36189894
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth
    Hwang Y; Kim LC; Song W; Edwards DN; Cook RS; Chen J
    Cancer Res; 2019 Jul; 79(13):3178-3184. PubMed ID: 31085701
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
    Woo SY; Kim DH; Jun CB; Kim YM; Haar EV; Lee SI; Hegg JW; Bandhakavi S; Griffin TJ; Kim DH
    J Biol Chem; 2007 Aug; 282(35):25604-12. PubMed ID: 17599906
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly.
    Luo Q; Chai X; Xin X; Ouyang W; Deng F
    Diabetol Metab Syndr; 2023 Mar; 15(1):49. PubMed ID: 36927703
    [TBL] [Abstract][Full Text] [Related]  

  • 15. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
    García-Martínez JM; Alessi DR
    Biochem J; 2008 Dec; 416(3):375-85. PubMed ID: 18925875
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin.
    Zou Z; Chen J; Yang J; Bai X
    Curr Cancer Drug Targets; 2016; 16(4):288-304. PubMed ID: 26563881
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
    Yang G; Murashige DS; Humphrey SJ; James DE
    Cell Rep; 2015 Aug; 12(6):937-43. PubMed ID: 26235620
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation.
    Chen Y; Jiao D; He H; Sun H; Liu Y; Shi Q; Zhang P; Li Y; Mo R; Gao K; Wang C
    Redox Biol; 2023 Nov; 67():102872. PubMed ID: 37688978
    [TBL] [Abstract][Full Text] [Related]  

  • 19. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
    Kim SJ; DeStefano MA; Oh WJ; Wu CC; Vega-Cotto NM; Finlan M; Liu D; Su B; Jacinto E
    Mol Cell; 2012 Dec; 48(6):875-87. PubMed ID: 23142081
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Disentangling the signaling pathways of mTOR complexes, mTORC1 and mTORC2, as a therapeutic target in glioblastoma.
    Jhanwar-Uniyal M; Dominguez JF; Mohan AL; Tobias ME; Gandhi CD
    Adv Biol Regul; 2022 Jan; 83():100854. PubMed ID: 34996736
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 35.