181 related articles for article (PubMed ID: 28501621)
1. Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.
Adachi R; Okada K; Skene R; Ogawa K; Miwa M; Tsuchinaga K; Ohkubo S; Henta T; Kawamoto T
Biochem Biophys Res Commun; 2017 Jun; 488(2):393-399. PubMed ID: 28501621
[TBL] [Abstract][Full Text] [Related]
2. Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Pang L; Weeks SD; Juhás M; Strelkov SV; Zitko J; Van Aerschot A
Int J Mol Sci; 2021 Jul; 22(15):. PubMed ID: 34360555
[TBL] [Abstract][Full Text] [Related]
3. Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
Son J; Lee EH; Park M; Kim JH; Kim J; Kim S; Jeon YH; Hwang KY
Acta Crystallogr D Biol Crystallogr; 2013 Oct; 69(Pt 10):2136-45. PubMed ID: 24100331
[TBL] [Abstract][Full Text] [Related]
4. Identification of Selective Novel Hits against
Nyamai DW; Tastan Bishop Ö
Int J Mol Sci; 2020 May; 21(11):. PubMed ID: 32471245
[TBL] [Abstract][Full Text] [Related]
5. Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.
Shibata A; Kuno M; Adachi R; Sato Y; Hattori H; Matsuda A; Okuzono Y; Igaki K; Tominari Y; Takagi T; Yabuki M; Okaniwa M
PLoS One; 2017; 12(10):e0186587. PubMed ID: 29065190
[TBL] [Abstract][Full Text] [Related]
6. Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis.
Wu J; Subbaiah KCV; Xie LH; Jiang F; Khor ES; Mickelsen D; Myers JR; Tang WHW; Yao P
Circ Res; 2020 Aug; 127(6):827-846. PubMed ID: 32611237
[TBL] [Abstract][Full Text] [Related]
7. Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.
Manickam Y; Malhotra N; Mishra S; Babbar P; Dusane A; Laleu B; Bellini V; Hakimi MA; Bougdour A; Sharma A
PLoS Pathog; 2022 Mar; 18(3):e1010363. PubMed ID: 35333915
[TBL] [Abstract][Full Text] [Related]
8. A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase.
Yaremchuk A; Tukalo M; Grøtli M; Cusack S
J Mol Biol; 2001 Jun; 309(4):989-1002. PubMed ID: 11399074
[TBL] [Abstract][Full Text] [Related]
9. Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation.
Arita T; Morimoto M; Yamamoto Y; Miyashita H; Kitazawa S; Hirayama T; Sakamoto S; Miyamoto K; Adachi R; Iwatani M; Hara T
Biochem Biophys Res Commun; 2017 Jul; 488(4):648-654. PubMed ID: 28087278
[TBL] [Abstract][Full Text] [Related]
10. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Zhou H; Sun L; Yang XL; Schimmel P
Nature; 2013 Feb; 494(7435):121-4. PubMed ID: 23263184
[TBL] [Abstract][Full Text] [Related]
11. Inhibitors of aminoacyl-tRNA synthetases as antimycobacterial compounds: An up-to-date review.
Bouz G; Zitko J
Bioorg Chem; 2021 May; 110():104806. PubMed ID: 33799176
[TBL] [Abstract][Full Text] [Related]
12. Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Nautiyal M; De Graef S; Pang L; Gadakh B; Strelkov SV; Weeks SD; Van Aerschot A
Eur J Med Chem; 2019 Jul; 173():154-166. PubMed ID: 30995568
[TBL] [Abstract][Full Text] [Related]
13. Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening.
Shapiro AB; Plant H; Walsh J; Sylvester M; Hu J; Gao N; Livchak S; Tentarelli S; Thresher J
J Biomol Screen; 2014 Sep; 19(8):1137-46. PubMed ID: 24820111
[TBL] [Abstract][Full Text] [Related]
14. Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites.
Stathopoulos C; Jacquin-Becker C; Becker HD; Li T; Ambrogelly A; Longman R; Söll D
Biochemistry; 2001 Jan; 40(1):46-52. PubMed ID: 11141055
[TBL] [Abstract][Full Text] [Related]
15. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Keller TL; Zocco D; Sundrud MS; Hendrick M; Edenius M; Yum J; Kim YJ; Lee HK; Cortese JF; Wirth DF; Dignam JD; Rao A; Yeo CY; Mazitschek R; Whitman M
Nat Chem Biol; 2012 Feb; 8(3):311-7. PubMed ID: 22327401
[TBL] [Abstract][Full Text] [Related]
16. Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase.
Lipman RS; Wang J; Sowers KR; Hou YM
J Mol Biol; 2002 Feb; 315(5):943-9. PubMed ID: 11827467
[TBL] [Abstract][Full Text] [Related]
17. A new mechanism of post-transfer editing by aminoacyl-tRNA synthetases: catalysis of hydrolytic reaction by bacterial-type prolyl-tRNA synthetase.
Boyarshin KS; Priss AE; Rayevskiy AV; Ilchenko MM; Dubey IY; Kriklivyi IA; Yaremchuk AD; Tukalo MA
J Biomol Struct Dyn; 2017 Feb; 35(3):669-682. PubMed ID: 26886480
[TBL] [Abstract][Full Text] [Related]
18. Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Yogavel M; Bougdour A; Mishra S; Malhotra N; Chhibber-Goel J; Bellini V; Harlos K; Laleu B; Hakimi MA; Sharma A
PLoS Pathog; 2023 Feb; 19(2):e1011124. PubMed ID: 36854028
[TBL] [Abstract][Full Text] [Related]
19. Anti-Phytophthora Activity of Halofuginone and the Corresponding Mode of Action.
Zhang S; Cai J; Xie Y; Zhang X; Yang X; Lin S; Xiang W; Zhang J
J Agric Food Chem; 2022 Oct; 70(39):12364-12371. PubMed ID: 36126316
[TBL] [Abstract][Full Text] [Related]
20. Aminoacyl-tRNA synthetase inhibitors as potent antibacterials.
Lv PC; Zhu HL
Curr Med Chem; 2012; 19(21):3550-63. PubMed ID: 22680640
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]