182 related articles for article (PubMed ID: 28511909)
1. Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator.
Matsui Y; Yasumatsu I; Asahi T; Kitamura T; Kanai K; Ubukata O; Hayasaka H; Takaishi S; Hanzawa H; Katakura S
Bioorg Med Chem; 2017 Jul; 25(13):3540-3546. PubMed ID: 28511909
[TBL] [Abstract][Full Text] [Related]
2. Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators.
Li R; Ning X; Zhou S; Lin Z; Wu X; Chen H; Bai X; Wang X; Ge Z; Li R; Yin Y
Eur J Med Chem; 2018 Jan; 143():48-65. PubMed ID: 29172082
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform.
Ning X; Qi H; Li R; Jin Y; McNutt MA; Yin Y
J Enzyme Inhib Med Chem; 2018 Dec; 33(1):126-129. PubMed ID: 29185365
[TBL] [Abstract][Full Text] [Related]
4. Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity.
Chen C; Wang T; Wu F; Huang W; He G; Ouyang L; Xiang M; Peng C; Jiang Q
Drug Des Devel Ther; 2014; 8():1195-210. PubMed ID: 25214764
[TBL] [Abstract][Full Text] [Related]
5. Computer-aided identification of a novel pyruvate kinase M2 activator compound.
Li Y; Bao M; Yang C; Chen J; Zhou S; Sun R; Wu C; Li X; Bao J
Cell Prolif; 2018 Dec; 51(6):e12509. PubMed ID: 30133040
[TBL] [Abstract][Full Text] [Related]
6. Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase.
Ning X; Qi H; Li R; Li Y; Jin Y; McNutt MA; Liu J; Yin Y
Eur J Med Chem; 2017 Sep; 138():343-352. PubMed ID: 28688274
[TBL] [Abstract][Full Text] [Related]
7. Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small-cell lung cancer (NSCLC).
Li RZ; Fan XX; Shi DF; Zhu GY; Wang YW; Luo LX; Pan HD; Yao XJ; Leung EL; Liu L
Chem Biol Drug Des; 2018 Nov; 92(5):1851-1858. PubMed ID: 29931766
[TBL] [Abstract][Full Text] [Related]
8. New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compounds.
Zhang Y; Liu B; Wu X; Li R; Ning X; Liu Y; Liu Z; Ge Z; Li R; Yin Y
Bioorg Med Chem; 2015 Aug; 23(15):4815-4823. PubMed ID: 26081759
[TBL] [Abstract][Full Text] [Related]
9. Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.
Patle R; Shinde S; Patel S; Maheshwari R; Jariyal H; Srivastava A; Chauhan N; Globisch C; Jain A; Tekade RK; Shard A
Bioorg Med Chem Lett; 2021 Jun; 42():128062. PubMed ID: 33901643
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of novel sulfonamide derivatives containing pyridin-3-ylmethyl 4-(benzoyl)piperazine-1-carbodithioate moiety as potent PKM2 activators.
Li R; Ning X; He J; Lin Z; Su Y; Li R; Yin Y
Bioorg Chem; 2021 Mar; 108():104653. PubMed ID: 33517002
[TBL] [Abstract][Full Text] [Related]
11. Structure-Guided Approach to Discover Tuberosin as a Potent Activator of Pyruvate Kinase M2, Targeting Cancer Therapy.
Adnan M; Shamsi A; Elasbali AM; Siddiqui AJ; Patel M; Alshammari N; Alharethi SH; Alhassan HH; Bardakci F; Hassan MI
Int J Mol Sci; 2022 Oct; 23(21):. PubMed ID: 36361954
[TBL] [Abstract][Full Text] [Related]
12. Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis.
Shan S; Shi J; Yang P; Jia B; Wu H; Zhang X; Li Z
J Agric Food Chem; 2017 Sep; 65(37):8136-8144. PubMed ID: 28829588
[TBL] [Abstract][Full Text] [Related]
13. Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors.
Liu B; Yuan X; Xu B; Zhang H; Li R; Wang X; Ge Z; Li R
Eur J Med Chem; 2019 May; 170():1-15. PubMed ID: 30878825
[TBL] [Abstract][Full Text] [Related]
14. Pyruvate kinase activators as a therapy target: a patent review 2011-2017.
Adem S; Comakli V; Uzun N
Expert Opin Ther Pat; 2018 Jan; 28(1):61-68. PubMed ID: 28994333
[TBL] [Abstract][Full Text] [Related]
15. Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.
Tamada M; Suematsu M; Saya H
Clin Cancer Res; 2012 Oct; 18(20):5554-61. PubMed ID: 23071357
[TBL] [Abstract][Full Text] [Related]
16. Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2).
Xu Y; Liu XH; Saunders M; Pearce S; Foulks JM; Parnell KM; Clifford A; Nix RN; Bullough J; Hendrickson TF; Wright K; McCullar MV; Kanner SB; Ho KK
Bioorg Med Chem Lett; 2014 Jan; 24(2):515-9. PubMed ID: 24374270
[TBL] [Abstract][Full Text] [Related]
17. Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase.
Mor I; Carlessi R; Ast T; Feinstein E; Kimchi A
Oncogene; 2012 Feb; 31(6):683-93. PubMed ID: 21725354
[TBL] [Abstract][Full Text] [Related]
18. Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo.
Ding Y; Xue Q; Liu S; Hu K; Wang D; Wang T; Li Y; Guo H; Hao X; Ge W; Zhang Y; Li A; Li J; Chen Y; Zhang Q
J Med Chem; 2020 Feb; 63(4):1597-1611. PubMed ID: 31977207
[TBL] [Abstract][Full Text] [Related]
19. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2.
Yoon YJ; Kim YH; Jin Y; Chi SW; Moon JH; Han DC; Kwon BM
Cancer Lett; 2018 Oct; 434():42-55. PubMed ID: 30009856
[TBL] [Abstract][Full Text] [Related]
20. Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.
Guo C; Linton A; Jalaie M; Kephart S; Ornelas M; Pairish M; Greasley S; Richardson P; Maegley K; Hickey M; Li J; Wu X; Ji X; Xie Z
Bioorg Med Chem Lett; 2013 Jun; 23(11):3358-63. PubMed ID: 23622982
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]