231 related articles for article (PubMed ID: 28515263)
1. Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.
Fliegert R; Watt JM; Schöbel A; Rozewitz MD; Moreau C; Kirchberger T; Thomas MP; Sick W; Araujo AC; Harneit A; Potter BVL; Guse AH
Biochem J; 2017 Jun; 474(13):2159-2175. PubMed ID: 28515263
[TBL] [Abstract][Full Text] [Related]
2. Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.
Baszczyňski O; Watt JM; Rozewitz MD; Guse AH; Fliegert R; Potter BVL
J Org Chem; 2019 May; 84(10):6143-6157. PubMed ID: 30978018
[TBL] [Abstract][Full Text] [Related]
3. Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2.
Yu P; Xue X; Zhang J; Hu X; Wu Y; Jiang LH; Jin H; Luo J; Zhang L; Liu Z; Yang W
J Gen Physiol; 2017 Feb; 149(2):219-235. PubMed ID: 28108595
[TBL] [Abstract][Full Text] [Related]
4. Functional importance of NUDT9H domain and N-terminal ADPR-binding pocket in two species variants of vertebrate TRPM2 channels.
Kühn FJP; Ehrlich W; Barth D; Kühn C; Lückhoff A
Sci Rep; 2019 Dec; 9(1):19224. PubMed ID: 31844070
[TBL] [Abstract][Full Text] [Related]
5. Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2.
Kühn FJ; Lückhoff A
J Biol Chem; 2004 Nov; 279(45):46431-7. PubMed ID: 15347676
[TBL] [Abstract][Full Text] [Related]
6. Structures and gating mechanism of human TRPM2.
Wang L; Fu TM; Zhou Y; Xia S; Greka A; Wu H
Science; 2018 Dec; 362(6421):. PubMed ID: 30467180
[TBL] [Abstract][Full Text] [Related]
7. The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity.
Iordanov I; Mihályi C; Tóth B; Csanády L
Elife; 2016 Jul; 5():. PubMed ID: 27383051
[TBL] [Abstract][Full Text] [Related]
8. Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel.
Tóth B; Iordanov I; Csanády L
J Gen Physiol; 2020 May; 152(5):. PubMed ID: 32211872
[TBL] [Abstract][Full Text] [Related]
9. ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain.
Kühn FJ; Kühn C; Winking M; Hoffmann DC; Lückhoff A
PLoS One; 2016; 11(6):e0158060. PubMed ID: 27333281
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.
Moreau C; Kirchberger T; Swarbrick JM; Bartlett SJ; Fliegert R; Yorgan T; Bauche A; Harneit A; Guse AH; Potter BV
J Med Chem; 2013 Dec; 56(24):10079-102. PubMed ID: 24304219
[TBL] [Abstract][Full Text] [Related]
11. Intracellular calcium activates TRPM2 and its alternative spliced isoforms.
Du J; Xie J; Yue L
Proc Natl Acad Sci U S A; 2009 Apr; 106(17):7239-44. PubMed ID: 19372375
[TBL] [Abstract][Full Text] [Related]
12. Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR.
Kühn FJP; Watt JM; Potter BVL; Lückhoff A
Sci Rep; 2019 Mar; 9(1):4985. PubMed ID: 30899048
[TBL] [Abstract][Full Text] [Related]
13. Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket.
Yu P; Liu Z; Yu X; Ye P; Liu H; Xue X; Yang L; Li Z; Wu Y; Fang C; Zhao YJ; Yang F; Luo JH; Jiang LH; Zhang L; Zhang L; Yang W
Cell Rep; 2019 Jun; 27(12):3684-3695.e4. PubMed ID: 31216484
[TBL] [Abstract][Full Text] [Related]
14. Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate.
Csanády L; Törocsik B
J Gen Physiol; 2009 Feb; 133(2):189-203. PubMed ID: 19171771
[TBL] [Abstract][Full Text] [Related]
15. Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Huang Y; Roth B; Lü W; Du J
Elife; 2019 Sep; 8():. PubMed ID: 31513012
[TBL] [Abstract][Full Text] [Related]
16. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.
Perraud AL; Takanishi CL; Shen B; Kang S; Smith MK; Schmitz C; Knowles HM; Ferraris D; Li W; Zhang J; Stoddard BL; Scharenberg AM
J Biol Chem; 2005 Feb; 280(7):6138-48. PubMed ID: 15561722
[TBL] [Abstract][Full Text] [Related]
17. The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn
Sander S; Pick J; Gattkowski E; Fliegert R; Tidow H
Protein Sci; 2022 Jun; 31(6):e4320. PubMed ID: 35634784
[TBL] [Abstract][Full Text] [Related]
18. Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9.
Gattkowski E; Rutherford TJ; Möckl F; Bauche A; Sander S; Fliegert R; Tidow H
FEBS J; 2021 Dec; 288(23):6769-6782. PubMed ID: 34189846
[TBL] [Abstract][Full Text] [Related]
19. Lys1110 of TRPM2 is critical for channel activation.
Kim TK; Nam JH; Ahn WG; Kim NH; Ham HY; Hong CW; Nam JS; Lee J; Huh SO; So I; Kim SJ; Song DK
Biochem J; 2013 Nov; 455(3):319-27. PubMed ID: 23957292
[TBL] [Abstract][Full Text] [Related]
20. Regulation of TRPM2 by extra- and intracellular calcium.
Starkus J; Beck A; Fleig A; Penner R
J Gen Physiol; 2007 Oct; 130(4):427-40. PubMed ID: 17893195
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]