BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

315 related articles for article (PubMed ID: 28533411)

  • 1. Bidirectional regulation of Aβ levels by Presenilin 1.
    Bustos V; Pulina MV; Kelahmetoglu Y; Sinha SC; Gorelick FS; Flajolet M; Greengard P
    Proc Natl Acad Sci U S A; 2017 Jul; 114(27):7142-7147. PubMed ID: 28533411
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.
    Bustos V; Pulina MV; Bispo A; Lam A; Flajolet M; Gorelick FS; Greengard P
    Proc Natl Acad Sci U S A; 2017 Jul; 114(27):7148-7153. PubMed ID: 28533369
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
    Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
    J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Amyloidogenic and anti-amyloidogenic properties of presenilin 1.
    Bustos V; Pulina MV; Ledo J
    Adv Pharmacol; 2021; 90():239-251. PubMed ID: 33706935
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
    Ledo JH; Liebmann T; Zhang R; Chang JC; Azevedo EP; Wong E; Silva HM; Troyanskaya OG; Bustos V; Greengard P
    Mol Psychiatry; 2021 Oct; 26(10):5620-5635. PubMed ID: 32792660
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice.
    Tian T; Bai D; Li W; Huang GW; Liu H
    Nutrients; 2016 Sep; 8(9):. PubMed ID: 27618097
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768421
    [TBL] [Abstract][Full Text] [Related]  

  • 9. γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.
    Hedskog L; Petersen CA; Svensson AI; Welander H; Tjernberg LO; Karlström H; Ankarcrona M
    J Cell Mol Med; 2011 Oct; 15(10):2150-63. PubMed ID: 21054783
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
    Cai Z; Wang C; He W; Chen Y
    Curr Alzheimer Res; 2018; 15(11):1045-1052. PubMed ID: 29962345
    [TBL] [Abstract][Full Text] [Related]  

  • 12. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
    Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.
    Li T; Li YM; Ahn K; Price DL; Sisodia SS; Wong PC
    PLoS One; 2011; 6(11):e28179. PubMed ID: 22140537
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.
    Sakae N; Liu CC; Shinohara M; Frisch-Daiello J; Ma L; Yamazaki Y; Tachibana M; Younkin L; Kurti A; Carrasquillo MM; Zou F; Sevlever D; Bisceglio G; Gan M; Fol R; Knight P; Wang M; Han X; Fryer JD; Fitzgerald ML; Ohyagi Y; Younkin SG; Bu G; Kanekiyo T
    J Neurosci; 2016 Mar; 36(13):3848-59. PubMed ID: 27030769
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Specific Mutations in Aph1 Cause γ-Secretase Activation.
    Watanabe H; Yoshida C; Hidaka M; Ogawa T; Tomita T; Futai E
    Int J Mol Sci; 2022 Jan; 23(1):. PubMed ID: 35008932
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
    Cacquevel M; Aeschbach L; Houacine J; Fraering PC
    PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.
    Sun Z; Xie Y; Chen Y; Yang Q; Quan Z; Dai R; Qing H
    Mol Neurobiol; 2018 May; 55(5):3841-3855. PubMed ID: 28547526
    [TBL] [Abstract][Full Text] [Related]  

  • 18. GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.
    Tian J; Shi J; Zhang L; Yin J; Hu Q; Xu Y; Sheng S; Wang P; Ren Y; Wang R; Wang Y
    Curr Alzheimer Res; 2009 Apr; 6(2):118-31. PubMed ID: 19355846
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W
    Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
    Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
    J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.