BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

250 related articles for article (PubMed ID: 28545714)

  • 1. Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease.
    Hwang VJ; Zhou X; Chen X; Trott J; Abu Aboud O; Shim K; Dionne LK; Chmiel KJ; Senapedis W; Baloglu E; Mahjoub MR; Li X; Weiss RH
    Kidney Int; 2017 Oct; 92(4):922-933. PubMed ID: 28545714
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.
    Abu Aboud O; Chen CH; Senapedis W; Baloglu E; Argueta C; Weiss RH
    Mol Cancer Ther; 2016 Sep; 15(9):2119-29. PubMed ID: 27390344
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting the vulnerability to NAD
    Takao S; Chien W; Madan V; Lin DC; Ding LW; Sun QY; Mayakonda A; Sudo M; Xu L; Chen Y; Jiang YY; Gery S; Lill M; Park E; Senapedis W; Baloglu E; Müschen M; Koeffler HP
    Leukemia; 2018 Mar; 32(3):616-625. PubMed ID: 28904384
    [TBL] [Abstract][Full Text] [Related]  

  • 4. KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells.
    Cordover E; Wei J; Patel C; Shan NL; Gionco J; Sargsyan D; Wu R; Cai L; Kong AN; Jacinto E; Minden A
    Chem Res Toxicol; 2020 Feb; 33(2):482-491. PubMed ID: 31876149
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.
    Rane C; Senapedis W; Baloglu E; Landesman Y; Crochiere M; Das-Gupta S; Minden A
    Sci Rep; 2017 Feb; 7():42555. PubMed ID: 28198380
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model.
    Pastor-Soler NM; Li H; Pham J; Rivera D; Ho PY; Mancino V; Saitta B; Hallows KR
    Am J Physiol Renal Physiol; 2022 Jan; 322(1):F27-F41. PubMed ID: 34806449
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.
    de Stephanis L; Bonon A; Varani K; Lanza G; Gafà R; Pinton P; Pema M; Somlo S; Boletta A; Aguiari G
    Clin Exp Nephrol; 2017 Apr; 21(2):203-211. PubMed ID: 27278932
    [TBL] [Abstract][Full Text] [Related]  

  • 8. TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease.
    Lee EJ; Seo E; Kim JW; Nam SA; Lee JY; Jun J; Oh S; Park M; Jho EH; Yoo KH; Park JH; Kim YK
    Proc Natl Acad Sci U S A; 2020 Nov; 117(46):29001-29012. PubMed ID: 33122431
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia.
    Li N; Lopez MA; Linares M; Kumar S; Oliva S; Martinez-Lopez J; Xu L; Xu Y; Perini T; Senapedis W; Baloglu E; Shammas MA; Hunter Z; Anderson KC; Treon SP; Munshi NC; Fulciniti M
    Clin Cancer Res; 2019 Jan; 25(1):369-377. PubMed ID: 30206161
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.
    Li A; Xu Y; Fan S; Meng J; Shen X; Xiao Q; Li Y; Zhang L; Zhang X; Wu G; Liang C; Wu D
    JCI Insight; 2018 Mar; 3(5):. PubMed ID: 29515026
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.
    Leonhard WN; van der Wal A; Novalic Z; Kunnen SJ; Gansevoort RT; Breuning MH; de Heer E; Peters DJ
    Am J Physiol Renal Physiol; 2011 May; 300(5):F1193-202. PubMed ID: 21345977
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.
    Tan M; Wettersten HI; Chu K; Huso DL; Watnick T; Friedlander S; Landesman Y; Weiss RH
    Am J Physiol Renal Physiol; 2014 Dec; 307(11):F1179-86. PubMed ID: 25234309
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Berberine slows cell growth in autosomal dominant polycystic kidney disease cells.
    Bonon A; Mangolini A; Pinton P; Del Senno L; Aguiari G
    Biochem Biophys Res Commun; 2013 Nov; 441(3):668-74. PubMed ID: 24184483
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus.
    Mpilla GB; Uddin MH; Al-Hallak MN; Aboukameel A; Li Y; Kim SH; Beydoun R; Dyson G; Baloglu E; Senapedis WT; Landesman Y; Wagner KU; Viola NT; El-Rayes BF; Philip PA; Mohammad RM; Azmi AS
    Mol Cancer Ther; 2021 Oct; 20(10):1836-1845. PubMed ID: 34253597
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.
    Li A; Fan S; Xu Y; Meng J; Shen X; Mao J; Zhang L; Zhang X; Moeckel G; Wu D; Wu G; Liang C
    J Cell Mol Med; 2017 Aug; 21(8):1619-1635. PubMed ID: 28244683
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease.
    Weisser I; Eckberg K; D'Amico S; Buttram D; Aboudehen K
    J Am Soc Nephrol; 2024 Jan; 35(1):41-55. PubMed ID: 37953472
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease.
    Wang X; Jiang L; Thao K; Sussman CR; LaBranche T; Palmer M; Harris PC; McKnight GS; Hoeflich KP; Schalm S; Torres VE
    J Am Soc Nephrol; 2022 Jun; 33(6):1087-1104. PubMed ID: 35236775
    [TBL] [Abstract][Full Text] [Related]  

  • 18. STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.
    Fragiadaki M; Lannoy M; Themanns M; Maurer B; Leonhard WN; Peters DJ; Moriggl R; Ong AC
    Kidney Int; 2017 Mar; 91(3):575-586. PubMed ID: 28104302
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease.
    Jamadar A; Suma SM; Mathew S; Fields TA; Wallace DP; Calvet JP; Rao R
    Cell Death Dis; 2021 Oct; 12(10):947. PubMed ID: 34650051
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis.
    Patera F; Cudzich-Madry A; Huang Z; Fragiadaki M
    Sci Rep; 2019 Mar; 9(1):4491. PubMed ID: 30872773
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.