BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 28546420)

  • 1. Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin.
    Yan L; Wang Y; Liu J; Nie Y; Zhong XB; Kan Q; Zhang L
    Mol Pharmacol; 2017 Aug; 92(2):113-123. PubMed ID: 28546420
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.
    Svecova L; Vrzal R; Burysek L; Anzenbacherova E; Cerveny L; Grim J; Trejtnar F; Kunes J; Pour M; Staud F; Anzenbacher P; Dvorak Z; Pavek P
    Drug Metab Dispos; 2008 Feb; 36(2):339-48. PubMed ID: 17998298
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells.
    Wang X; Yu Y; Wang P; Yang K; Wang Y; Yan L; Zhong XB; Zhang L
    Drug Metab Dispos; 2022 May; 50(5):704-715. PubMed ID: 34949673
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
    Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
    Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.
    Liu CL; Lim YP; Hu ML
    Mar Drugs; 2012 Jan; 10(1):242-257. PubMed ID: 22363234
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.
    Rasmussen MK; Daujat-Chavanieu M; Gerbal-Chaloin S
    Toxicol Lett; 2017 Aug; 277():1-8. PubMed ID: 28571685
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
    Kim S; Dinchuk JE; Anthony MN; Orcutt T; Zoeckler ME; Sauer MB; Mosure KW; Vuppugalla R; Grace JE; Simmermacher J; Dulac HA; Pizzano J; Sinz M
    Drug Metab Dispos; 2010 Jan; 38(1):16-24. PubMed ID: 19833845
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.
    Tan H; Xu C; Zeng H; Wang Y; Li Y; Fan X; Chen P; Jiang Y; Chen X; Huang M; Bi H
    J Pharmacol Sci; 2016 Feb; 130(2):66-71. PubMed ID: 26782648
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
    Kobayashi K; Kuze J; Abe S; Takehara S; Minegishi G; Igarashi K; Kitajima S; Kanno J; Yamamoto T; Oshimura M; Kazuki Y
    Mol Pharmacol; 2019 Nov; 96(5):600-608. PubMed ID: 31455676
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors.
    Zhang W; Purchio A; Chen K; Burns SM; Contag CH; Contag PR
    Biochem Pharmacol; 2003 Jun; 65(11):1889-96. PubMed ID: 12781341
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.
    Taneja G; Chu C; Maturu P; Moorthy B; Ghose R
    Drug Metab Dispos; 2018 Apr; 46(4):397-404. PubMed ID: 29440179
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.
    Fang HL; Strom SC; Ellis E; Duanmu Z; Fu J; Duniec-Dmuchowski Z; Falany CN; Falany JL; Kocarek TA; Runge-Morris M
    J Pharmacol Exp Ther; 2007 Nov; 323(2):586-98. PubMed ID: 17687072
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.
    Goodwin B; Hodgson E; Liddle C
    Mol Pharmacol; 1999 Dec; 56(6):1329-39. PubMed ID: 10570062
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
    Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
    Lim YP; Huang JD
    Pharmacogenet Genomics; 2007 May; 17(5):369-82. PubMed ID: 17429319
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.
    Lim YP; Kuo SC; Lai ML; Huang JD
    Pharmacogenet Genomics; 2009 Jan; 19(1):11-24. PubMed ID: 19077665
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
    Gupta A; Mugundu GM; Desai PB; Thummel KE; Unadkat JD
    Drug Metab Dispos; 2008 Jun; 36(6):1172-80. PubMed ID: 18332086
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
    Liu FJ; Song X; Yang D; Deng R; Yan B
    Biochem J; 2008 Jan; 409(1):243-50. PubMed ID: 17764444
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system.
    Raucy J; Warfe L; Yueh MF; Allen SW
    J Pharmacol Exp Ther; 2002 Oct; 303(1):412-23. PubMed ID: 12235278
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.