These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 28552578)

  • 1. Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
    Moreno-Morcillo M; Grande-García A; Ruiz-Ramos A; Del Caño-Ochoa F; Boskovic J; Ramón-Maiques S
    Structure; 2017 Jun; 25(6):912-923.e5. PubMed ID: 28552578
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD.
    Del Caño-Ochoa F; Rubio-Del-Campo A; Ramón-Maiques S
    Molecules; 2023 Jan; 28(2):. PubMed ID: 36677714
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD.
    Ruiz-Ramos A; Lallous N; Grande-García A; Ramón-Maiques S
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2013 Dec; 69(Pt 12):1425-30. PubMed ID: 24316846
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CAD, A Multienzymatic Protein at the Head of de Novo Pyrimidine Biosynthesis.
    Del Caño-Ochoa F; Moreno-Morcillo M; Ramón-Maiques S
    Subcell Biochem; 2019; 93():505-538. PubMed ID: 31939163
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Allosteric regulation and substrate channeling in multifunctional pyrimidine biosynthetic complexes: analysis of isolated domains and yeast-mammalian chimeric proteins.
    Serre V; Guy H; Liu X; Penverne B; Hervé G; Evans D
    J Mol Biol; 1998 Aug; 281(2):363-77. PubMed ID: 9698553
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Immunochemical analysis of the domain structure of CAD, the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells.
    Grayson DR; Lee L; Evans DR
    J Biol Chem; 1985 Dec; 260(29):15840-9. PubMed ID: 2866187
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.
    Zhang P; Martin PD; Purcarea C; Vaishnav A; Brunzelle JS; Fernando R; Guy-Evans HI; Evans DR; Edwards BF
    Biochemistry; 2009 Feb; 48(4):766-78. PubMed ID: 19128030
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional linkage between the glutaminase and synthetase domains of carbamoyl-phosphate synthetase. Role of serine 44 in carbamoyl-phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (cad).
    Hewagama A; Guy HI; Vickrey JF; Evans DR
    J Biol Chem; 1999 Oct; 274(40):28240-5. PubMed ID: 10497179
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
    Del Caño-Ochoa F; Grande-García A; Reverte-López M; D'Abramo M; Ramón-Maiques S
    J Biol Chem; 2018 Dec; 293(49):18903-18913. PubMed ID: 30315107
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CAD gene sequence and the domain structure of the mammalian multifunctional protein CAD.
    Evans DR; Bein K; Guy HI; Liu X; Molina JA; Zimmermann BH
    Biochem Soc Trans; 1993 Feb; 21(1):186-91. PubMed ID: 8095469
    [No Abstract]   [Full Text] [Related]  

  • 11. Intersubunit communication in the dihydroorotase-aspartate transcarbamoylase complex of Aquifex aeolicus.
    Evans HG; Fernando R; Vaishnav A; Kotichukkala M; Heyl D; Hachem F; Brunzelle JS; Edwards BF; Evans DR
    Protein Sci; 2014 Jan; 23(1):100-9. PubMed ID: 24353170
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Deciphering CAD: Structure and function of a mega-enzymatic pyrimidine factory in health and disease.
    Del Caño-Ochoa F; Ramón-Maiques S
    Protein Sci; 2021 Oct; 30(10):1995-2008. PubMed ID: 34288185
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD.
    Lindsey-Boltz LA; Wauson EM; Graves LM; Sancar A
    Nucleic Acids Res; 2004; 32(15):4524-30. PubMed ID: 15326225
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi.
    Nara T; Hashimoto M; Hirawake H; Liao CW; Fukai Y; Suzuki S; Tsubouchi A; Morales J; Takamiya S; Fujimura T; Taka H; Mineki R; Fan CK; Inaoka DK; Inoue M; Tanaka A; Harada S; Kita K; Aoki T
    Biochem Biophys Res Commun; 2012 Feb; 418(1):140-3. PubMed ID: 22245425
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphorylation, allosteric effectors and inter-domain contacts in CAD; their role in regulation of early steps of pyrimidine biosynthesis.
    Carrey EA
    Biochem Soc Trans; 1993 Feb; 21(1):191-5. PubMed ID: 8095470
    [No Abstract]   [Full Text] [Related]  

  • 16. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD.
    Lallous N; Grande-García A; Molina R; Ramón-Maiques S
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2012 Nov; 68(Pt 11):1341-5. PubMed ID: 23143245
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
    Sato T; Akasu H; Shimono W; Matsu C; Fujiwara Y; Shibagaki Y; Heard JJ; Tamanoi F; Hattori S
    J Biol Chem; 2015 Jan; 290(2):1096-105. PubMed ID: 25422319
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The dihydroorotase domain of the multifunctional protein CAD. Subunit structure, zinc content, and kinetics.
    Kelly RE; Mally MI; Evans DR
    J Biol Chem; 1986 May; 261(13):6073-83. PubMed ID: 2871022
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of Latent Dihydroorotase from Aquifex aeolicus by Pressure.
    Hervé G; Evans HG; Fernado R; Patel C; Hachem F; Evans DR
    J Biol Chem; 2017 Jan; 292(2):629-637. PubMed ID: 27746403
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of carbamoyl phosphate synthetase by MAP kinase.
    Graves LM; Guy HI; Kozlowski P; Huang M; Lazarowski E; Pope RM; Collins MA; Dahlstrand EN; Earp HS; Evans DR
    Nature; 2000 Jan; 403(6767):328-32. PubMed ID: 10659854
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.