BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 28580921)

  • 1. Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates.
    Deschamps P; Réty S; Bareille J; Leulliot N
    Acta Crystallogr F Struct Biol Commun; 2017 Jun; 73(Pt 6):336-341. PubMed ID: 28580921
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chemical shift imprint of intersubunit communication in a symmetric homodimer.
    Falk BT; Sapienza PJ; Lee AL
    Proc Natl Acad Sci U S A; 2016 Aug; 113(34):9533-8. PubMed ID: 27466406
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.
    Gibson LM; Celeste LR; Lovelace LL; Lebioda L
    Acta Crystallogr D Biol Crystallogr; 2011 Jan; 67(Pt 1):60-6. PubMed ID: 21206062
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
    Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
    J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
    Newby Z; Lee TT; Morse RJ; Liu Y; Liu L; Venkatraman P; Santi DV; Finer-Moore JS; Stroud RM
    Biochemistry; 2006 Jun; 45(24):7415-28. PubMed ID: 16768437
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
    Chen D; Jansson A; Sim D; Larsson A; Nordlund P
    J Biol Chem; 2017 Aug; 292(32):13449-13458. PubMed ID: 28634233
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.
    Griffin J; Roshick C; Iliffe-Lee E; McClarty G
    J Biol Chem; 2005 Feb; 280(7):5456-67. PubMed ID: 15591067
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
    Phan J; Steadman DJ; Koli S; Ding WC; Minor W; Dunlap RB; Berger SH; Lebioda L
    J Biol Chem; 2001 Apr; 276(17):14170-7. PubMed ID: 11278511
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
    Almog R; Waddling CA; Maley F; Maley GF; Van Roey P
    Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
    Stout TJ; Stroud RM
    Structure; 1996 Jan; 4(1):67-77. PubMed ID: 8805515
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
    Finer-Moore JS; Fauman EB; Morse RJ; Santi DV; Stroud RM
    Protein Eng; 1996 Jan; 9(1):69-75. PubMed ID: 9053905
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.
    Luo B; Repalli J; Yousef AM; Johnson SR; Lebioda L; Berger SH
    Protein Sci; 2011 Jan; 20(1):87-94. PubMed ID: 21064161
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
    Finer-Moore JS; Liu L; Schafmeister CE; Birdsall DL; Mau T; Santi DV; Stroud RM
    Biochemistry; 1996 Apr; 35(16):5125-36. PubMed ID: 8611496
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195.
    Gibson LM; Lovelace LL; Lebioda L
    Biochemistry; 2008 Apr; 47(16):4636-43. PubMed ID: 18370400
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A novel dCMP methylase by engineering thymidylate synthase.
    Agarwalla S; LaPorte S; Liu L; Finer-Moore J; Stroud RM; Santi DV
    Biochemistry; 1997 Dec; 36(50):15909-17. PubMed ID: 9398324
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.
    Pozzi C; Ferrari S; Luciani R; Costi MP; Mangani S
    Molecules; 2019 Apr; 24(7):. PubMed ID: 30959951
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystal structure of mouse thymidylate synthase in tertiary complex with dUMP and raltitrexed reveals N-terminus architecture and two different active site conformations.
    Dowierciał A; Wilk P; Rypniewski W; Rode W; Jarmuła A
    Biomed Res Int; 2014; 2014():945803. PubMed ID: 24995339
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate.
    Costi PM; Liu L; Finer-Moore JS; Stroud RM; Santi DV
    Biochemistry; 1996 Apr; 35(13):3944-9. PubMed ID: 8672425
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
    Anderson AC; Perry KM; Freymann DM; Stroud RM
    J Mol Biol; 2000 Mar; 297(3):645-57. PubMed ID: 10731418
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.
    Perry KM; Carreras CW; Chang LC; Santi DV; Stroud RM
    Biochemistry; 1993 Jul; 32(28):7116-25. PubMed ID: 8343503
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.