204 related articles for article (PubMed ID: 28595015)
1. 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Zhou S; Mahmoud S; Liu P; Zhou L; Ehteshami M; Bassit L; Tao S; Domaoal RA; Sari O; Schutter C; Amiralaei S; Khalil A; Ollinger Russell O; McBrayer T; Whitaker T; Abou-Taleb N; Amblard F; Coats SJ; Schinazi RF
J Med Chem; 2017 Jul; 60(13):5424-5437. PubMed ID: 28595015
[TBL] [Abstract][Full Text] [Related]
2. Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
Mengshetti S; Zhou L; Sari O; De Schutter C; Zhang H; Cho JH; Tao S; Bassit LC; Verma K; Domaoal RA; Ehteshami M; Jiang Y; Ovadia R; Kasthuri M; Ollinger Russell O; McBrayer T; Whitaker T; Pattassery J; Pascual ML; Uher L; Lin BY; Lee S; Amblard F; Coats SJ; Schinazi RF
J Med Chem; 2019 Feb; 62(4):1859-1874. PubMed ID: 30653317
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
Chris Krueger A; Chen HJ; Randolph JT; Brown BS; Halvorsen GT; Heyman HR; Li T; Marvin CC; Shanley JP; Voight EA; Bow DAJ; Van Handel C; Peterkin V; Carr RA; Stolarik D; Dekhtyar T; Irvin ML; Krishnan P; Henry RF; Wagner R; DeGoey DA
Bioorg Med Chem; 2020 Jan; 28(1):115208. PubMed ID: 31740203
[TBL] [Abstract][Full Text] [Related]
4. Discovery of β-d-2'-deoxy-2'-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication.
Pinho P; Kalayanov G; Westerlind H; Rosenquist Å; Wähling H; Sund C; Almeida M; Ayesa S; Tejbrant J; Targett-Adams P; Eneroth A; Lindqvist A
Bioorg Med Chem Lett; 2017 Aug; 27(15):3468-3471. PubMed ID: 28622881
[TBL] [Abstract][Full Text] [Related]
5. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Lam AM; Murakami E; Espiritu C; Steuer HM; Niu C; Keilman M; Bao H; Zennou V; Bourne N; Julander JG; Morrey JD; Smee DF; Frick DN; Heck JA; Wang P; Nagarathnam D; Ross BS; Sofia MJ; Otto MJ; Furman PA
Antimicrob Agents Chemother; 2010 Aug; 54(8):3187-96. PubMed ID: 20516278
[TBL] [Abstract][Full Text] [Related]
6. A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.
Liu J; Du J; Wang P; Nagarathnam D; Espiritu CL; Bao H; Murakami E; Furman PA; Sofia MJ
Nucleosides Nucleotides Nucleic Acids; 2012 Apr; 31(4):277-85. PubMed ID: 22444190
[TBL] [Abstract][Full Text] [Related]
7. Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Kirschberg TA; Metobo S; Clarke MO; Aktoudianakis V; Babusis D; Barauskas O; Birkus G; Butler T; Byun D; Chin G; Doerffler E; Edwards TE; Fenaux M; Lee R; Lew W; Mish MR; Murakami E; Park Y; Squires NH; Tirunagari N; Wang T; Whitcomb M; Xu J; Yang H; Ye H; Zhang L; Appleby TC; Feng JY; Ray AS; Cho A; Kim CU
Bioorg Med Chem Lett; 2017 Apr; 27(8):1840-1847. PubMed ID: 28274633
[TBL] [Abstract][Full Text] [Related]
8. Synthesis of 2'-deoxy-2'-fluoro-2'-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase.
Singh US; Chu CK
Nucleosides Nucleotides Nucleic Acids; 2020; 39(1-3):52-68. PubMed ID: 32310031
[TBL] [Abstract][Full Text] [Related]
9. Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.
Randolph JT; Li T; Chris Krueger A; Heyman HR; Chen HJ; Bow DAJ; Van Handel C; Peterkin V; Carr RA; Stolarik D; Dekhtyar T; Irvin M; Krishnan P; Wagner R; DeGoey DA
Bioorg Med Chem Lett; 2020 Apr; 30(7):126986. PubMed ID: 32046903
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Feng JY; Cheng G; Perry J; Barauskas O; Xu Y; Fenaux M; Eng S; Tirunagari N; Peng B; Yu M; Tian Y; Lee YJ; Stepan G; Lagpacan LL; Jin D; Hung M; Ku KS; Han B; Kitrinos K; Perron M; Birkus G; Wong KA; Zhong W; Kim CU; Carey A; Cho A; Ray AS
Antimicrob Agents Chemother; 2014; 58(4):1930-42. PubMed ID: 24419349
[TBL] [Abstract][Full Text] [Related]
11. Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.
Furman PA; Murakami E; Niu C; Lam AM; Espiritu C; Bansal S; Bao H; Tolstykh T; Micolochick Steuer H; Keilman M; Zennou V; Bourne N; Veselenak RL; Chang W; Ross BS; Du J; Otto MJ; Sofia MJ
Antiviral Res; 2011 Aug; 91(2):120-32. PubMed ID: 21600932
[TBL] [Abstract][Full Text] [Related]
12. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.
Sofia MJ; Bao D; Chang W; Du J; Nagarathnam D; Rachakonda S; Reddy PG; Ross BS; Wang P; Zhang HR; Bansal S; Espiritu C; Keilman M; Lam AM; Steuer HM; Niu C; Otto MJ; Furman PA
J Med Chem; 2010 Oct; 53(19):7202-18. PubMed ID: 20845908
[TBL] [Abstract][Full Text] [Related]
13. β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.
Du J; Bao D; Chun BK; Jiang Y; Reddy PG; Zhang HR; Ross BS; Bansal S; Bao H; Espiritu C; Lam AM; Murakami E; Niu C; Micolochick Steuer HM; Furman PA; Otto MJ; Sofia MJ
Bioorg Med Chem Lett; 2012 Sep; 22(18):5924-9. PubMed ID: 22892115
[TBL] [Abstract][Full Text] [Related]
14. Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.
Jonckers TH; Tahri A; Vijgen L; Berke JM; Lachau-Durand S; Stoops B; Snoeys J; Leclercq L; Tambuyzer L; Lin TI; Simmen K; Raboisson P
J Med Chem; 2016 Jun; 59(12):5790-8. PubMed ID: 27181575
[TBL] [Abstract][Full Text] [Related]
15. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus.
Good SS; Moussa A; Zhou XJ; Pietropaolo K; Sommadossi JP
PLoS One; 2020; 15(1):e0227104. PubMed ID: 31914458
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
Wang G; Dyatkina N; Prhavc M; Williams C; Serebryany V; Hu Y; Huang Y; Wan J; Wu X; Deval J; Fung A; Jin Z; Tan H; Shaw K; Kang H; Zhang Q; Tam Y; Stoycheva A; Jekle A; Smith DB; Beigelman L
J Med Chem; 2019 May; 62(9):4555-4570. PubMed ID: 30951311
[TBL] [Abstract][Full Text] [Related]
17. Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
Ehteshami M; Tao S; Ozturk T; Zhou L; Cho JH; Zhang H; Amiralaei S; Shelton JR; Lu X; Khalil A; Domaoal RA; Stanton RA; Suesserman JE; Lin B; Lee SS; Amblard F; Whitaker T; Coats SJ; Schinazi RF
Antimicrob Agents Chemother; 2016 Aug; 60(8):4659-69. PubMed ID: 27216050
[TBL] [Abstract][Full Text] [Related]
18. Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.
Maiti M; Gao LJ; Huang C; Ptak RG; Murray MG; De Jonghe S; Herdewijn P
Org Biomol Chem; 2016 Sep; 14(37):8743-8757. PubMed ID: 27714209
[TBL] [Abstract][Full Text] [Related]
19. The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.
Alexandre FR; Badaroux E; Bilello JP; Bot S; Bouisset T; Brandt G; Cappelle S; Chapron C; Chaves D; Convard T; Counor C; Da Costa D; Dukhan D; Gay M; Gosselin G; Griffon JF; Gupta K; Hernandez-Santiago B; La Colla M; Lioure MP; Milhau J; Paparin JL; Peyronnet J; Parsy C; Pierra Rouvière C; Rahali H; Rahali R; Salanson A; Seifer M; Serra I; Standring D; Surleraux D; Dousson CB
Bioorg Med Chem Lett; 2017 Sep; 27(18):4323-4330. PubMed ID: 28835346
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of
Wang G; Dyatkina N; Prhavc M; Williams C; Serebryany V; Hu Y; Huang Y; Wu X; Chen T; Huang W; Rajwanshi VK; Deval J; Fung A; Jin Z; Stoycheva A; Shaw K; Gupta K; Tam Y; Jekle A; Smith DB; Beigelman L
J Med Chem; 2020 Sep; 63(18):10380-10395. PubMed ID: 32816483
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
