BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

346 related articles for article (PubMed ID: 28597297)

  • 1. Intrinsic protein disorder in oncogenic KRAS signaling.
    Nussinov R; Jang H; Tsai CJ; Liao TJ; Li S; Fushman D; Zhang J
    Cell Mol Life Sci; 2017 Sep; 74(17):3245-3261. PubMed ID: 28597297
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?
    Nussinov R; Tsai CJ; Jang H
    Semin Cancer Biol; 2019 Feb; 54():114-120. PubMed ID: 29307569
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oncogenic Ras Isoforms Signaling Specificity at the Membrane.
    Nussinov R; Tsai CJ; Jang H
    Cancer Res; 2018 Feb; 78(3):593-602. PubMed ID: 29273632
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.
    Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
    Mol Cancer Res; 2015 Sep; 13(9):1265-73. PubMed ID: 26085527
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
    Jang H; Banerjee A; Chavan T; Gaponenko V; Nussinov R
    J Biol Chem; 2017 Jul; 292(30):12544-12559. PubMed ID: 28623230
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.
    Nussinov R; Zhang M; Tsai CJ; Jang H
    Biochim Biophys Acta Mol Basis Dis; 2018 Jun; 1864(6 Pt B):2304-2314. PubMed ID: 29097261
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.
    Jang H; Muratcioglu S; Gursoy A; Keskin O; Nussinov R
    Biochem J; 2016 Jun; 473(12):1719-32. PubMed ID: 27057007
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.
    Muratcioglu S; Aydin C; Odabasi E; Ozdemir ES; Firat-Karalar EN; Jang H; Tsai CJ; Nussinov R; Kavakli IH; Gursoy A; Keskin O
    J Mol Biol; 2020 Feb; 432(4):1199-1215. PubMed ID: 31931009
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.
    Nussinov R; Tsai CJ; Muratcioglu S; Jang H; Gursoy A; Keskin O
    Expert Rev Proteomics; 2015; 12(6):669-82. PubMed ID: 26496174
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
    Li X; Dai J; Ni D; He X; Zhang H; Zhang J; Fu Q; Liu Y; Lu S
    Int J Biol Macromol; 2020 Feb; 144():643-655. PubMed ID: 31816384
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
    Mazhab-Jafari MT; Marshall CB; Smith MJ; Gasmi-Seabrook GM; Stathopulos PB; Inagaki F; Kay LE; Neel BG; Ikura M
    Proc Natl Acad Sci U S A; 2015 May; 112(21):6625-30. PubMed ID: 25941399
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The dynamic mechanism of RASSF5 and MST kinase activation by Ras.
    Liao TJ; Jang H; Tsai CJ; Fushman D; Nussinov R
    Phys Chem Chem Phys; 2017 Mar; 19(9):6470-6480. PubMed ID: 28197608
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A New View of Ras Isoforms in Cancers.
    Nussinov R; Tsai CJ; Chakrabarti M; Jang H
    Cancer Res; 2016 Jan; 76(1):18-23. PubMed ID: 26659836
    [TBL] [Abstract][Full Text] [Related]  

  • 14. K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?
    Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
    Expert Opin Ther Targets; 2016 Jul; 20(7):831-42. PubMed ID: 26873344
    [TBL] [Abstract][Full Text] [Related]  

  • 15. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
    Hatzivassiliou G; Song K; Yen I; Brandhuber BJ; Anderson DJ; Alvarado R; Ludlam MJ; Stokoe D; Gloor SL; Vigers G; Morales T; Aliagas I; Liu B; Sideris S; Hoeflich KP; Jaiswal BS; Seshagiri S; Koeppen H; Belvin M; Friedman LS; Malek S
    Nature; 2010 Mar; 464(7287):431-5. PubMed ID: 20130576
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Membrane Composition and Raf[CRD]-Membrane Attachment Are Driving Forces for K-Ras4B Dimer Stability.
    Andreadelis I; Kiriakidi S; Lamprakis C; Theodoropoulou A; Doerr S; Chatzigoulas A; Manchester J; Velez-Vega C; Duca JS; Cournia Z
    J Phys Chem B; 2022 Feb; 126(7):1504-1519. PubMed ID: 35142524
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Calmodulin and PI3K Signaling in
    Nussinov R; Wang G; Tsai CJ; Jang H; Lu S; Banerjee A; Zhang J; Gaponenko V
    Trends Cancer; 2017 Mar; 3(3):214-224. PubMed ID: 28462395
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of wild type RAS isoforms in cancer.
    Zhou B; Der CJ; Cox AD
    Semin Cell Dev Biol; 2016 Oct; 58():60-9. PubMed ID: 27422332
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling.
    Villalonga P; López-Alcalá C; Bosch M; Chiloeches A; Rocamora N; Gil J; Marais R; Marshall CJ; Bachs O; Agell N
    Mol Cell Biol; 2001 Nov; 21(21):7345-54. PubMed ID: 11585916
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
    Oliva JL; Zarich N; Martínez N; Jorge R; Castrillo A; Azañedo M; García-Vargas S; Gutiérrez-Eisman S; Juarranz A; Boscá L; Gutkind JS; Rojas JM
    J Biol Chem; 2004 Aug; 279(32):33480-91. PubMed ID: 15181015
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.