These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Dragovich PS; Bair KW; Baumeister T; Ho YC; Liederer BM; Liu X; Liu Y; O'Brien T; Oeh J; Sampath D; Skelton N; Wang L; Wang W; Wu H; Xiao Y; Yuen PW; Zak M; Zhang L; Zheng X Bioorg Med Chem Lett; 2013 Sep; 23(17):4875-85. PubMed ID: 23899614 [TBL] [Abstract][Full Text] [Related]
3. Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Zheng X; Baumeister T; Buckmelter AJ; Caligiuri M; Clodfelter KH; Han B; Ho YC; Kley N; Lin J; Reynolds DJ; Sharma G; Smith CC; Wang Z; Dragovich PS; Oh A; Wang W; Zak M; Wang Y; Yuen PW; Bair KW Bioorg Med Chem Lett; 2014 Jan; 24(1):337-43. PubMed ID: 24279990 [TBL] [Abstract][Full Text] [Related]
4. Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies. Clark DE; Waszkowycz B; Wong M; Lockey PM; Adalbert R; Gilley J; Clark J; Coleman MP Bioorg Med Chem Lett; 2016 Jun; 26(12):2920-2926. PubMed ID: 27158141 [TBL] [Abstract][Full Text] [Related]
5. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Zheng X; Bauer P; Baumeister T; Buckmelter AJ; Caligiuri M; Clodfelter KH; Han B; Ho YC; Kley N; Lin J; Reynolds DJ; Sharma G; Smith CC; Wang Z; Dragovich PS; Oh A; Wang W; Zak M; Gunzner-Toste J; Zhao G; Yuen PW; Bair KW J Med Chem; 2013 Jun; 56(12):4921-37. PubMed ID: 23617784 [TBL] [Abstract][Full Text] [Related]
6. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Dragovich PS; Zhao G; Baumeister T; Bravo B; Giannetti AM; Ho YC; Hua R; Li G; Liang X; Ma X; O'Brien T; Oh A; Skelton NJ; Wang C; Wang W; Wang Y; Xiao Y; Yuen PW; Zak M; Zhao Q; Zheng X Bioorg Med Chem Lett; 2014 Feb; 24(3):954-62. PubMed ID: 24433859 [TBL] [Abstract][Full Text] [Related]
7. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Zheng X; Bair KW; Bauer P; Baumeister T; Bowman KK; Buckmelter AJ; Caligiuri M; Clodfelter KH; Feng Y; Han B; Ho YC; Kley N; Li H; Liang X; Liederer BM; Lin J; Ly J; O'Brien T; Oeh J; Oh A; Reynolds DJ; Sampath D; Sharma G; Skelton N; Smith CC; Tremayne J; Wang L; Wang W; Wang Z; Wu H; Wu J; Xiao Y; Yang G; Yuen PW; Zak M; Dragovich PS Bioorg Med Chem Lett; 2013 Oct; 23(20):5488-97. PubMed ID: 24021463 [TBL] [Abstract][Full Text] [Related]
8. Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Oh A; Ho YC; Zak M; Liu Y; Chen X; Yuen PW; Zheng X; Liu Y; Dragovich PS; Wang W Chembiochem; 2014 May; 15(8):1121-30. PubMed ID: 24797455 [TBL] [Abstract][Full Text] [Related]
9. Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities. Bai J; Liao C; Liu Y; Qin X; Chen J; Qiu Y; Qin D; Li Z; Tu ZC; Jiang S J Med Chem; 2016 Jun; 59(12):5766-79. PubMed ID: 27224875 [TBL] [Abstract][Full Text] [Related]
11. Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Gunzner-Toste J; Zhao G; Bauer P; Baumeister T; Buckmelter AJ; Caligiuri M; Clodfelter KH; Fu B; Han B; Ho YC; Kley N; Liang X; Liederer BM; Lin J; Mukadam S; O'Brien T; Oh A; Reynolds DJ; Sharma G; Skelton N; Smith CC; Sodhi J; Wang W; Wang Z; Xiao Y; Yuen PW; Zak M; Zhang L; Zheng X; Bair KW; Dragovich PS Bioorg Med Chem Lett; 2013 Jun; 23(12):3531-8. PubMed ID: 23668988 [TBL] [Abstract][Full Text] [Related]
12. Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase. Olesen UH; Petersen JG; Garten A; Kiess W; Yoshino J; Imai S; Christensen MK; Fristrup P; Thougaard AV; Björkling F; Jensen PB; Nielsen SJ; Sehested M BMC Cancer; 2010 Dec; 10():677. PubMed ID: 21144000 [TBL] [Abstract][Full Text] [Related]
13. Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase. Chen W; Dong G; He S; Xu T; Wang X; Liu N; Zhang W; Miao C; Sheng C Bioorg Med Chem Lett; 2016 Feb; 26(3):765-768. PubMed ID: 26755394 [TBL] [Abstract][Full Text] [Related]
14. Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. Zak M; Yuen PW; Liu X; Patel S; Sampath D; Oeh J; Liederer BM; Wang W; O'Brien T; Xiao Y; Skelton N; Hua R; Sodhi J; Wang Y; Zhang L; Zhao G; Zheng X; Ho YC; Bair KW; Dragovich PS J Med Chem; 2016 Sep; 59(18):8345-68. PubMed ID: 27541271 [TBL] [Abstract][Full Text] [Related]
16. Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer. Zhang W; Zhang K; Yao Y; Liu Y; Ni Y; Liao C; Tu Z; Qiu Y; Wang D; Chen D; Qiang L; Li Z; Jiang S Eur J Med Chem; 2021 Feb; 211():113022. PubMed ID: 33239261 [TBL] [Abstract][Full Text] [Related]
17. Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT. Wang X; Xu TY; Liu XZ; Zhang SL; Wang P; Li ZY; Guan YF; Wang SN; Dong GQ; Zhuo S; Le YY; Sheng CQ; Miao CY Sci Rep; 2015 Jul; 5():12657. PubMed ID: 26227784 [TBL] [Abstract][Full Text] [Related]
18. Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen. Palacios DS; Meredith E; Kawanami T; Adams C; Chen X; Darsigny V; Geno E; Palermo M; Baird D; Boynton G; Busby SA; George EL; Guy C; Hewett J; Tierney L; Thigale S; Weihofen W; Wang L; White N; Yin M; Argikar UA Bioorg Med Chem Lett; 2018 Feb; 28(3):365-370. PubMed ID: 29275937 [TBL] [Abstract][Full Text] [Related]
19. Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. Zheng X; Bauer P; Baumeister T; Buckmelter AJ; Caligiuri M; Clodfelter KH; Han B; Ho YC; Kley N; Lin J; Reynolds DJ; Sharma G; Smith CC; Wang Z; Dragovich PS; Gunzner-Toste J; Liederer BM; Ly J; O'Brien T; Oh A; Wang L; Wang W; Xiao Y; Zak M; Zhao G; Yuen PW; Bair KW J Med Chem; 2013 Aug; 56(16):6413-33. PubMed ID: 23859118 [TBL] [Abstract][Full Text] [Related]
20. Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Zak M; Liederer BM; Sampath D; Yuen PW; Bair KW; Baumeister T; Buckmelter AJ; Clodfelter KH; Cheng E; Crocker L; Fu B; Han B; Li G; Ho YC; Lin J; Liu X; Ly J; O'Brien T; Reynolds DJ; Skelton N; Smith CC; Tay S; Wang W; Wang Z; Xiao Y; Zhang L; Zhao G; Zheng X; Dragovich PS Bioorg Med Chem Lett; 2015 Feb; 25(3):529-41. PubMed ID: 25556090 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]