408 related articles for article (PubMed ID: 28612181)
1. Low-Density Lipoprotein Receptor-Related Protein-1 (LRP1) C4408R Mutant Promotes Amyloid Precursor Protein (APP) α-Cleavage in Vitro.
Hou H; Habib A; Zi D; Tian K; Tian J; Giunta B; Sawmiller D; Tan J
Neuromolecular Med; 2017 Sep; 19(2-3):300-308. PubMed ID: 28612181
[TBL] [Abstract][Full Text] [Related]
2. Specific antibody binding to the APP672-699 region shifts APP processing from α- to β-cleavage.
Li S; Deng J; Hou H; Tian J; Giunta B; Wang Y; Sawmiller D; Smith A; Sanberg PR; Obregon D; Mori T; Tan J
Cell Death Dis; 2014 Aug; 5(8):e1374. PubMed ID: 25118934
[TBL] [Abstract][Full Text] [Related]
3. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
[TBL] [Abstract][Full Text] [Related]
4. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
5. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.
Yoon IS; Chen E; Busse T; Repetto E; Lakshmana MK; Koo EH; Kang DE
FASEB J; 2007 Sep; 21(11):2742-52. PubMed ID: 17463224
[TBL] [Abstract][Full Text] [Related]
6. Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.
Lakshmana MK; Yoon IS; Chen E; Bianchi E; Koo EH; Kang DE
J Biol Chem; 2009 May; 284(18):11863-72. PubMed ID: 19251705
[TBL] [Abstract][Full Text] [Related]
7. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
Thinakaran G; Teplow DB; Siman R; Greenberg B; Sisodia SS
J Biol Chem; 1996 Apr; 271(16):9390-7. PubMed ID: 8621605
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.
Shackleton B; Crawford F; Bachmeier C
Fluids Barriers CNS; 2016 Aug; 13(1):14. PubMed ID: 27503326
[TBL] [Abstract][Full Text] [Related]
9. LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.
Van Gool B; Storck SE; Reekmans SM; Lechat B; Gordts PLSM; Pradier L; Pietrzik CU; Roebroek AJM
Mol Neurobiol; 2019 Oct; 56(10):7234-7245. PubMed ID: 31004319
[TBL] [Abstract][Full Text] [Related]
10. Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site.
Wang J; Gleeson PA; Fourriere L
Traffic; 2024 Mar; 25(3):e12932. PubMed ID: 38528836
[TBL] [Abstract][Full Text] [Related]
11. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
[TBL] [Abstract][Full Text] [Related]
12. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
Jäger S; Leuchtenberger S; Martin A; Czirr E; Wesselowski J; Dieckmann M; Waldron E; Korth C; Koo EH; Heneka M; Weggen S; Pietrzik CU
J Neurochem; 2009 Dec; 111(6):1369-82. PubMed ID: 19804379
[TBL] [Abstract][Full Text] [Related]
13. The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.
von Einem B; Schwanzar D; Rehn F; Beyer AS; Weber P; Wagner M; Schneckenburger H; von Arnim CA
Exp Neurol; 2010 Sep; 225(1):85-93. PubMed ID: 20685197
[TBL] [Abstract][Full Text] [Related]
14. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Kokawa A; Ishihara S; Fujiwara H; Nobuhara M; Iwata M; Ihara Y; Funamoto S
Acta Neuropathol Commun; 2015 Nov; 3():66. PubMed ID: 26531305
[TBL] [Abstract][Full Text] [Related]
15. Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer's Disease Mouse Model.
Guo C; Yang ZH; Zhang S; Chai R; Xue H; Zhang YH; Li JY; Wang ZY
Neuropsychopharmacology; 2017 Dec; 42(13):2504-2515. PubMed ID: 28079060
[TBL] [Abstract][Full Text] [Related]
16. Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement.
Habib A; Sawmiller D; Hou H; Kanithi M; Tian J; Zeng J; Zi D; He ZX; Sanberg PR; Tan J
Cell Transplant; 2018 Apr; 27(4):666-676. PubMed ID: 29871524
[TBL] [Abstract][Full Text] [Related]
17. O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-β protein precursor via inhibition of endocytosis from the plasma membrane.
Chun YS; Park Y; Oh HG; Kim TW; Yang HO; Park MK; Chung S
J Alzheimers Dis; 2015; 44(1):261-75. PubMed ID: 25208619
[TBL] [Abstract][Full Text] [Related]
18. Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.
Mei Z; Zhang F; Tao L; Zheng W; Cao Y; Wang Z; Tang S; Le K; Chen S; Pi R; Liu P
Neurosci Lett; 2009 Mar; 452(2):90-5. PubMed ID: 19154776
[TBL] [Abstract][Full Text] [Related]
19. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
20. High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.
Maesako M; Uemura M; Tashiro Y; Sasaki K; Watanabe K; Noda Y; Ueda K; Asada-Utsugi M; Kubota M; Okawa K; Ihara M; Shimohama S; Uemura K; Kinoshita A
PLoS One; 2015; 10(9):e0131199. PubMed ID: 26414661
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]