165 related articles for article (PubMed ID: 28613859)
1. Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.
Peauger L; Azzouz R; Gembus V; Ţînţaş ML; Sopková-de Oliveira Santos J; Bohn P; Papamicaël C; Levacher V
J Med Chem; 2017 Jul; 60(13):5909-5926. PubMed ID: 28613859
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
Lan JS; Zhang T; Liu Y; Yang J; Xie SS; Liu J; Miao ZY; Ding Y
Eur J Med Chem; 2017 Jun; 133():184-196. PubMed ID: 28388521
[TBL] [Abstract][Full Text] [Related]
3. Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.
Azzouz R; Peauger L; Gembus V; Ţînţaş ML; Sopková-de Oliveira Santos J; Papamicaël C; Levacher V
Eur J Med Chem; 2018 Feb; 145():165-190. PubMed ID: 29324339
[TBL] [Abstract][Full Text] [Related]
4. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.
van Greunen DG; Cordier W; Nell M; van der Westhuyzen C; Steenkamp V; Panayides JL; Riley DL
Eur J Med Chem; 2017 Feb; 127():671-690. PubMed ID: 27823887
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.
Yan J; Hu J; Liu A; He L; Li X; Wei H
Bioorg Med Chem; 2017 Jun; 25(12):2946-2955. PubMed ID: 28454848
[TBL] [Abstract][Full Text] [Related]
6. Donepezil: an important prototype to the design of new drug candidates for Alzheimer's disease.
Rodrigues Simões MC; Dias Viegas FP; Moreira MS; de Freitas Silva M; Riquiel MM; da Rosa PM; Castelli MR; dos Santos MH; Soares MG; Viegas C
Mini Rev Med Chem; 2014 Jan; 14(1):2-19. PubMed ID: 24251806
[TBL] [Abstract][Full Text] [Related]
7. Profiling donepezil template into multipotent hybrids with antioxidant properties.
Mezeiova E; Spilovska K; Nepovimova E; Gorecki L; Soukup O; Dolezal R; Malinak D; Janockova J; Jun D; Kuca K; Korabecny J
J Enzyme Inhib Med Chem; 2018 Dec; 33(1):583-606. PubMed ID: 29529892
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and biological activity of new donepezil-hydrazinonicotinamide hybrids.
Zurek E; Szymański P; Mikiciuk-Olasik E
Drug Res (Stuttg); 2013 Mar; 63(3):137-44. PubMed ID: 23447117
[TBL] [Abstract][Full Text] [Related]
9. Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies.
Ţînţaş ML; Gembus V; Alix F; Barré A; Coadou G; Truong L; Sebban M; Papamicaël C; Oulyadi H; Levacher V
Eur J Med Chem; 2018 Jul; 155():171-182. PubMed ID: 29886321
[TBL] [Abstract][Full Text] [Related]
10. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Wang ZM; Cai P; Liu QH; Xu DQ; Yang XL; Wu JJ; Kong LY; Wang XB
Eur J Med Chem; 2016 Nov; 123():282-297. PubMed ID: 27484514
[TBL] [Abstract][Full Text] [Related]
11. Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy.
Barré A; Azzouz R; Gembus V; Papamicaël C; Levacher V
Molecules; 2019 Apr; 24(7):. PubMed ID: 30939771
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Dias KS; de Paula CT; Dos Santos T; Souza IN; Boni MS; Guimarães MJ; da Silva FM; Castro NG; Neves GA; Veloso CC; Coelho MM; de Melo IS; Giusti FC; Giusti-Paiva A; da Silva ML; Dardenne LE; Guedes IA; Pruccoli L; Morroni F; Tarozzi A; Viegas C
Eur J Med Chem; 2017 Apr; 130():440-457. PubMed ID: 28282613
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
Hu Y; Zhang J; Chandrashankra O; Ip FC; Ip NY
Bioorg Med Chem; 2013 Feb; 21(3):676-83. PubMed ID: 23273608
[TBL] [Abstract][Full Text] [Related]
14. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.
Caliandro R; Pesaresi A; Cariati L; Procopio A; Oliverio M; Lamba D
J Enzyme Inhib Med Chem; 2018 Dec; 33(1):794-803. PubMed ID: 29651884
[TBL] [Abstract][Full Text] [Related]
15. De-novo Drug Design, Molecular Docking and In-Silico Molecular Prediction of AChEI Analogues through CADD Approaches as Anti-Alzheimer's Agents.
Pandey S; Singh BK
Curr Comput Aided Drug Des; 2020; 16(1):54-72. PubMed ID: 30827255
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Dias Viegas FP; de Freitas Silva M; Divino da Rocha M; Castelli MR; Riquiel MM; Machado RP; Vaz SM; Simões de Lima LM; Mancini KC; Marques de Oliveira PC; Morais ÉP; Gontijo VS; da Silva FMR; D'Alincourt da Fonseca Peçanha D; Castro NG; Neves GA; Giusti-Paiva A; Vilela FC; Orlandi L; Camps I; Veloso MP; Leomil Coelho LF; Ionta M; Ferreira-Silva GÁ; Pereira RM; Dardenne LE; Guedes IA; de Oliveira Carneiro Junior W; Quaglio Bellozi PM; Pinheiro de Oliveira AC; Ferreira FF; Pruccoli L; Tarozzi A; Viegas C
Eur J Med Chem; 2018 Mar; 147():48-65. PubMed ID: 29421570
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Wang J; Wang ZM; Li XM; Li F; Wu JJ; Kong LY; Wang XB
Bioorg Med Chem; 2016 Sep; 24(18):4324-4338. PubMed ID: 27460699
[TBL] [Abstract][Full Text] [Related]
18. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Bolea I; Juárez-Jiménez J; de Los Ríos C; Chioua M; Pouplana R; Luque FJ; Unzeta M; Marco-Contelles J; Samadi A
J Med Chem; 2011 Dec; 54(24):8251-70. PubMed ID: 22023459
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Bautista-Aguilera OM; Esteban G; Bolea I; Nikolic K; Agbaba D; Moraleda I; Iriepa I; Samadi A; Soriano E; Unzeta M; Marco-Contelles J
Eur J Med Chem; 2014 Mar; 75():82-95. PubMed ID: 24530494
[TBL] [Abstract][Full Text] [Related]
20. Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Clark JK; Cowley P; Muir AW; Palin R; Pow E; Prosser AB; Taylor R; Zhang MQ
Bioorg Med Chem Lett; 2002 Sep; 12(18):2565-8. PubMed ID: 12182861
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
