BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

343 related articles for article (PubMed ID: 28615207)

  • 1. Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells.
    Madison MK; Lawson DQ; Elliott J; Ozantürk AN; Koneru PC; Townsend D; Errando M; Kvaratskhelia M; Kutluay SB
    J Virol; 2017 Sep; 91(17):. PubMed ID: 28615207
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection.
    Eschbach JE; Elliott JL; Li W; Zadrozny KK; Davis K; Mohammed SJ; Lawson DQ; Pornillos O; Engelman AN; Kutluay SB
    J Virol; 2020 Dec; 95(2):. PubMed ID: 33115869
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation.
    Fontana J; Jurado KA; Cheng N; Ly NL; Fuchs JR; Gorelick RJ; Engelman AN; Steven AC
    J Virol; 2015 Oct; 89(19):9765-80. PubMed ID: 26178982
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome.
    van Bel N; van der Velden Y; Bonnard D; Le Rouzic E; Das AT; Benarous R; Berkhout B
    PLoS One; 2014; 9(7):e103552. PubMed ID: 25072705
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fates of retroviral core components during unrestricted and TRIM5-restricted infection.
    Kutluay SB; Perez-Caballero D; Bieniasz PD
    PLoS Pathog; 2013 Mar; 9(3):e1003214. PubMed ID: 23505372
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Multimodal Functionalities of HIV-1 Integrase.
    Engelman AN; Kvaratskhelia M
    Viruses; 2022 Apr; 14(5):. PubMed ID: 35632668
    [TBL] [Abstract][Full Text] [Related]  

  • 7. HIV-1 Maturation: Lessons Learned from Inhibitors.
    Kleinpeter AB; Freed EO
    Viruses; 2020 Aug; 12(9):. PubMed ID: 32858867
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase.
    Takahata T; Takeda E; Tobiume M; Tokunaga K; Yokoyama M; Huang YL; Hasegawa A; Shioda T; Sato H; Kannagi M; Masuda T
    J Virol; 2017 Jan; 91(1):. PubMed ID: 27795445
    [TBL] [Abstract][Full Text] [Related]  

  • 9. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
    Koneru PC; Francis AC; Deng N; Rebensburg SV; Hoyte AC; Lindenberger J; Adu-Ampratwum D; Larue RC; Wempe MF; Engelman AN; Lyumkis D; Fuchs JR; Levy RM; Melikyan GB; Kvaratskhelia M
    Elife; 2019 May; 8():. PubMed ID: 31120420
    [TBL] [Abstract][Full Text] [Related]  

  • 10. HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.
    Liu S; Koneru PC; Li W; Pathirage C; Engelman AN; Kvaratskhelia M; Musier-Forsyth K
    Retrovirology; 2021 Nov; 18(1):37. PubMed ID: 34809662
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
    Amadori C; van der Velden YU; Bonnard D; Orlov I; van Bel N; Le Rouzic E; Miralles L; Brias J; Chevreuil F; Spehner D; Chasset S; Ledoussal B; Mayr L; Moreau F; García F; Gatell J; Zamborlini A; Emiliani S; Ruff M; Klaholz BP; Moog C; Berkhout B; Plana M; Benarous R
    Retrovirology; 2017 Nov; 14(1):50. PubMed ID: 29121950
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.
    Balakrishnan M; Yant SR; Tsai L; O'Sullivan C; Bam RA; Tsai A; Niedziela-Majka A; Stray KM; Sakowicz R; Cihlar T
    PLoS One; 2013; 8(9):e74163. PubMed ID: 24040198
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.
    Kessl JJ; Kutluay SB; Townsend D; Rebensburg S; Slaughter A; Larue RC; Shkriabai N; Bakouche N; Fuchs JR; Bieniasz PD; Kvaratskhelia M
    Cell; 2016 Aug; 166(5):1257-1268.e12. PubMed ID: 27565348
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
    Feng L; Dharmarajan V; Serrao E; Hoyte A; Larue RC; Slaughter A; Sharma A; Plumb MR; Kessl JJ; Fuchs JR; Bushman FD; Engelman AN; Griffin PR; Kvaratskhelia M
    ACS Chem Biol; 2016 May; 11(5):1313-21. PubMed ID: 26910179
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
    Elliott JL; Eschbach JE; Koneru PC; Li W; Puray-Chavez M; Townsend D; Lawson DQ; Engelman AN; Kvaratskhelia M; Kutluay SB
    Elife; 2020 Sep; 9():. PubMed ID: 32960169
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
    Jurado KA; Wang H; Slaughter A; Feng L; Kessl JJ; Koh Y; Wang W; Ballandras-Colas A; Patel PA; Fuchs JR; Kvaratskhelia M; Engelman A
    Proc Natl Acad Sci U S A; 2013 May; 110(21):8690-5. PubMed ID: 23610442
    [TBL] [Abstract][Full Text] [Related]  

  • 17. LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.
    Desimmie BA; Schrijvers R; Demeulemeester J; Borrenberghs D; Weydert C; Thys W; Vets S; Van Remoortel B; Hofkens J; De Rijck J; Hendrix J; Bannert N; Gijsbers R; Christ F; Debyser Z
    Retrovirology; 2013 May; 10():57. PubMed ID: 23721378
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
    Feng L; Sharma A; Slaughter A; Jena N; Koh Y; Shkriabai N; Larue RC; Patel PA; Mitsuya H; Kessl JJ; Engelman A; Fuchs JR; Kvaratskhelia M
    J Biol Chem; 2013 May; 288(22):15813-20. PubMed ID: 23615903
    [TBL] [Abstract][Full Text] [Related]  

  • 19. RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly.
    Mattei S; Flemming A; Anders-Össwein M; Kräusslich HG; Briggs JA; Müller B
    J Virol; 2015 Oct; 89(19):9739-47. PubMed ID: 26178992
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
    Gupta K; Turkki V; Sherrill-Mix S; Hwang Y; Eilers G; Taylor L; McDanal C; Wang P; Temelkoff D; Nolte RT; Velthuisen E; Jeffrey J; Van Duyne GD; Bushman FD
    PLoS Biol; 2016 Dec; 14(12):e1002584. PubMed ID: 27935939
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.