113 related articles for article (PubMed ID: 28645614)
1. Site-1 protease, a novel metabolic target for glioblastoma.
Caruana BT; Skoric A; Brown AJ; Lutze-Mann LH
Biochem Biophys Res Commun; 2017 Aug; 490(3):760-766. PubMed ID: 28645614
[TBL] [Abstract][Full Text] [Related]
2. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals.
Hawkins JL; Robbins MD; Warren LC; Xia D; Petras SF; Valentine JJ; Varghese AH; Wang IK; Subashi TA; Shelly LD; Hay BA; Landschulz KT; Geoghegan KF; Harwood HJ
J Pharmacol Exp Ther; 2008 Sep; 326(3):801-8. PubMed ID: 18577702
[TBL] [Abstract][Full Text] [Related]
3. Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro.
Monnerie H; Romer M; Jensen BK; Millar JS; Jordan-Sciutto KL; Kim SF; Grinspan JB
J Neurochem; 2017 Jan; 140(1):53-67. PubMed ID: 27385127
[TBL] [Abstract][Full Text] [Related]
4. Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.
Olmstead AD; Knecht W; Lazarov I; Dixit SB; Jean F
PLoS Pathog; 2012 Jan; 8(1):e1002468. PubMed ID: 22241994
[TBL] [Abstract][Full Text] [Related]
5. Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.
Guan M; Fousek K; Jiang C; Guo S; Synold T; Xi B; Shih CC; Chow WA
Clin Cancer Res; 2011 Apr; 17(7):1796-806. PubMed ID: 21355074
[TBL] [Abstract][Full Text] [Related]
6. Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells.
De Windt A; Rai M; Bernier L; Thelen K; Soini J; Lefebvre C; Chintawar S; Lavigne J; Saarinen L; Kytömäki L; Munzer JS; Lütjohann D; Pandolfo M; Davignon J; Seidah NG; Laaksonen R
DNA Cell Biol; 2007 Nov; 26(11):765-72. PubMed ID: 17867930
[TBL] [Abstract][Full Text] [Related]
7. Spatial separation of Golgi and ER during mitosis protects SREBP from unregulated activation.
Bartz R; Sun LP; Bisel B; Wei JH; Seemann J
EMBO J; 2008 Apr; 27(7):948-55. PubMed ID: 18323777
[TBL] [Abstract][Full Text] [Related]
8. Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways.
Facchini G; Ignarro RS; Rodrigues-Silva E; Vieira AS; Lopes-Cendes I; Castilho RF; Rogerio F
J Neurooncol; 2018 Feb; 136(3):435-443. PubMed ID: 29159775
[TBL] [Abstract][Full Text] [Related]
9. Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD.
Deng X; Pan X; Cheng C; Liu B; Zhang H; Zhang Y; Xu K
Biochim Biophys Acta Mol Cell Biol Lipids; 2017 Mar; 1862(3):337-350. PubMed ID: 28011404
[TBL] [Abstract][Full Text] [Related]
10. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation.
Uchida L; Urata S; Ulanday GE; Takamatsu Y; Yasuda J; Morita K; Hayasaka D
Viruses; 2016 Feb; 8(2):. PubMed ID: 26875984
[TBL] [Abstract][Full Text] [Related]
11. Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer.
Guan M; Fousek K; Chow WA
FEBS J; 2012 Jul; 279(13):2399-411. PubMed ID: 22540830
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.
Geng F; Cheng X; Wu X; Yoo JY; Cheng C; Guo JY; Mo X; Ru P; Hurwitz B; Kim SH; Otero J; Puduvalli V; Lefai E; Ma J; Nakano I; Horbinski C; Kaur B; Chakravarti A; Guo D
Clin Cancer Res; 2016 Nov; 22(21):5337-5348. PubMed ID: 27281560
[TBL] [Abstract][Full Text] [Related]
13. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Patra D; DeLassus E; Liang G; Sandell LJ
PLoS One; 2014; 9(8):e105674. PubMed ID: 25147951
[TBL] [Abstract][Full Text] [Related]
14. SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth.
Wang TB; Geng M; Jin H; Tang AG; Sun H; Zhou LZ; Chen BH; Shen G; Sun Q
Cell Death Dis; 2021 Jul; 12(8):717. PubMed ID: 34285190
[TBL] [Abstract][Full Text] [Related]
15. Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins.
Cheng D; Espenshade PJ; Slaughter CA; Jaen JC; Brown MS; Goldstein JL
J Biol Chem; 1999 Aug; 274(32):22805-12. PubMed ID: 10428865
[TBL] [Abstract][Full Text] [Related]
16. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene.
Yang J; Goldstein JL; Hammer RE; Moon YA; Brown MS; Horton JD
Proc Natl Acad Sci U S A; 2001 Nov; 98(24):13607-12. PubMed ID: 11717426
[TBL] [Abstract][Full Text] [Related]
17. Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism.
Bayraktar EC; La K; Karpman K; Unlu G; Ozerdem C; Ritter DJ; Alwaseem H; Molina H; Hoffmann HH; Millner A; Atilla-Gokcumen GE; Gamazon ER; Rushing AR; Knapik EW; Basu S; Birsoy K
Nat Metab; 2020 Jun; 2(6):487-498. PubMed ID: 32694732
[TBL] [Abstract][Full Text] [Related]
18. U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells.
Schmitt M; Dehay B; Bezard E; Garcia-Ladona FJ
Synapse; 2017 Sep; 71(9):. PubMed ID: 28407359
[TBL] [Abstract][Full Text] [Related]
19. Proteolytic activation of SREBPs during adipocyte differentiation.
Inoue J; Kumagai H; Terada T; Maeda M; Shimizu M; Sato R
Biochem Biophys Res Commun; 2001 May; 283(5):1157-61. PubMed ID: 11355894
[TBL] [Abstract][Full Text] [Related]
20. Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER.
Bartz R; Seemann J
Cell Cycle; 2008 Jul; 7(14):2100-5. PubMed ID: 18635952
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
