199 related articles for article (PubMed ID: 28650719)
1. Computational investigation on the effects of H50Q and G51D mutations on the α-Synuclein aggregation propensity.
Sanjeev A; Mattaparthi VSK
J Biomol Struct Dyn; 2018 Jul; 36(9):2224-2236. PubMed ID: 28650719
[TBL] [Abstract][Full Text] [Related]
2. Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.
Rutherford NJ; Moore BD; Golde TE; Giasson BI
J Neurochem; 2014 Dec; 131(6):859-67. PubMed ID: 24984882
[TBL] [Abstract][Full Text] [Related]
3. Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.
Kiely AP; Ling H; Asi YT; Kara E; Proukakis C; Schapira AH; Morris HR; Roberts HC; Lubbe S; Limousin P; Lewis PA; Lees AJ; Quinn N; Hardy J; Love S; Revesz T; Houlden H; Holton JL
Mol Neurodegener; 2015 Aug; 10():41. PubMed ID: 26306801
[TBL] [Abstract][Full Text] [Related]
4. Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.
Murata T; Tochio N; Utsunomiya-Tate N
Neurosci Lett; 2021 Aug; 760():136077. PubMed ID: 34161822
[TBL] [Abstract][Full Text] [Related]
5. Oligomers of Parkinson's Disease-Related α-Synuclein Mutants Have Similar Structures but Distinctive Membrane Permeabilization Properties.
Stefanovic AN; Lindhoud S; Semerdzhiev SA; Claessens MM; Subramaniam V
Biochemistry; 2015 May; 54(20):3142-50. PubMed ID: 25909158
[TBL] [Abstract][Full Text] [Related]
6. Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein.
Leitao A; Bhumkar A; Hunter DJB; Gambin Y; Sierecki E
Int J Mol Sci; 2018 Jan; 19(2):. PubMed ID: 29364143
[TBL] [Abstract][Full Text] [Related]
7. The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
Khalaf O; Fauvet B; Oueslati A; Dikiy I; Mahul-Mellier AL; Ruggeri FS; Mbefo MK; Vercruysse F; Dietler G; Lee SJ; Eliezer D; Lashuel HA
J Biol Chem; 2014 Aug; 289(32):21856-76. PubMed ID: 24936070
[TBL] [Abstract][Full Text] [Related]
8. Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation.
Mason RJ; Paskins AR; Dalton CF; Smith DP
Biochemistry; 2016 Aug; 55(34):4737-41. PubMed ID: 27517125
[TBL] [Abstract][Full Text] [Related]
9. The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
Fares MB; Ait-Bouziad N; Dikiy I; Mbefo MK; Jovičić A; Kiely A; Holton JL; Lee SJ; Gitler AD; Eliezer D; Lashuel HA
Hum Mol Genet; 2014 Sep; 23(17):4491-509. PubMed ID: 24728187
[TBL] [Abstract][Full Text] [Related]
10. The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro.
Ghosh D; Mondal M; Mohite GM; Singh PK; Ranjan P; Anoop A; Ghosh S; Jha NN; Kumar A; Maji SK
Biochemistry; 2013 Oct; 52(40):6925-7. PubMed ID: 24047453
[TBL] [Abstract][Full Text] [Related]
11. The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.
Lau HHC; Martinez-Valbuena I; So RWL; Mehra S; Silver NRG; Mao A; Stuart E; Schmitt-Ulms C; Hyman BT; Ingelsson M; Kovacs GG; Watts JC
Acta Neuropathol Commun; 2023 May; 11(1):72. PubMed ID: 37138318
[TBL] [Abstract][Full Text] [Related]
12. Differential copper binding to alpha-synuclein and its disease-associated mutants affect the aggregation and amyloid formation.
Ranjan P; Ghosh D; Yarramala DS; Das S; Maji SK; Kumar A
Biochim Biophys Acta Gen Subj; 2017 Feb; 1861(2):365-374. PubMed ID: 27916677
[TBL] [Abstract][Full Text] [Related]
13. Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements.
Ruf VC; Nübling GS; Willikens S; Shi S; Schmidt F; Levin J; Bötzel K; Kamp F; Giese A
ACS Chem Neurosci; 2019 Mar; 10(3):1649-1659. PubMed ID: 30605594
[TBL] [Abstract][Full Text] [Related]
14. The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.
Xu CK; Castellana-Cruz M; Chen SW; Du Z; Meisl G; Levin A; Mannini B; Itzhaki LS; Knowles TPJ; Dobson CM; Cremades N; Kumita JR
Molecules; 2022 Feb; 27(4):. PubMed ID: 35209093
[TBL] [Abstract][Full Text] [Related]
15. The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
Porcari R; Proukakis C; Waudby CA; Bolognesi B; Mangione PP; Paton JF; Mullin S; Cabrita LD; Penco A; Relini A; Verona G; Vendruscolo M; Stoppini M; Tartaglia GG; Camilloni C; Christodoulou J; Schapira AH; Bellotti V
J Biol Chem; 2015 Jan; 290(4):2395-404. PubMed ID: 25505181
[TBL] [Abstract][Full Text] [Related]
16. Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein.
Guan Y; Zhao X; Liu F; Yan S; Wang Y; Du C; Cui X; Li R; Zhang CX
Front Cell Neurosci; 2020; 14():159. PubMed ID: 32595456
[TBL] [Abstract][Full Text] [Related]
17. A sensitive assay reveals structural requirements for α-synuclein fibril growth.
Dhavale DD; Tsai C; Bagchi DP; Engel LA; Sarezky J; Kotzbauer PT
J Biol Chem; 2017 Jun; 292(22):9034-9050. PubMed ID: 28373279
[TBL] [Abstract][Full Text] [Related]
18. Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.
Rutherford NJ; Dhillon JS; Riffe CJ; Howard JK; Brooks M; Giasson BI
Hum Mol Genet; 2017 Dec; 26(24):4906-4915. PubMed ID: 29036344
[TBL] [Abstract][Full Text] [Related]
19. Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
Villar-Piqué A; Lopes da Fonseca T; Sant'Anna R; Szegö ÉM; Fonseca-Ornelas L; Pinho R; Carija A; Gerhardt E; Masaracchia C; Abad Gonzalez E; Rossetti G; Carloni P; Fernández CO; Foguel D; Milosevic I; Zweckstetter M; Ventura S; Outeiro TF
Proc Natl Acad Sci U S A; 2016 Oct; 113(42):E6506-E6515. PubMed ID: 27708160
[TBL] [Abstract][Full Text] [Related]
20. Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence.
Sierecki E; Giles N; Bowden Q; Polinkovsky ME; Steinbeck J; Arrioti N; Rahman D; Bhumkar A; Nicovich PR; Ross I; Parton RG; Böcking T; Gambin Y
Sci Rep; 2016 Nov; 6():37630. PubMed ID: 27892477
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
