These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 28653847)

  • 1. Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8).
    Ma Y; Fu Y; Khojasteh SC; Dalvie D; Zhang D
    J Med Chem; 2017 Nov; 60(21):8691-8705. PubMed ID: 28653847
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges.
    Shah MB
    Biomolecules; 2022 Sep; 12(9):. PubMed ID: 36139056
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.
    Tornio A; Filppula AM; Kailari O; Neuvonen M; Nyrönen TH; Tapaninen T; Neuvonen PJ; Niemi M; Backman JT
    Clin Pharmacol Ther; 2014 Oct; 96(4):498-507. PubMed ID: 24971633
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.
    Backman JT; Filppula AM; Niemi M; Neuvonen PJ
    Pharmacol Rev; 2016 Jan; 68(1):168-241. PubMed ID: 26721703
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions.
    Ogilvie BW; Zhang D; Li W; Rodrigues AD; Gipson AE; Holsapple J; Toren P; Parkinson A
    Drug Metab Dispos; 2006 Jan; 34(1):191-7. PubMed ID: 16299161
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In Vitro Evidence of Potential Interactions between CYP2C8 and Candesartan Acyl-
    Katsube Y; Tsujimoto M; Koide H; Hira D; Ikeda Y; Minegaki T; Morita SY; Terada T; Nishiguchi K
    Drug Metab Dispos; 2021 Apr; 49(4):289-297. PubMed ID: 33446524
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug-Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil.
    Iga K; Kiriyama A
    Clin Pharmacokinet; 2024 Jan; 63(1):43-56. PubMed ID: 37921907
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.
    Kahma H; Filppula AM; Launiainen T; Viinamäki J; Neuvonen M; Evangelista EA; Totah RA; Backman JT
    Drug Metab Dispos; 2019 Apr; 47(4):436-443. PubMed ID: 30709838
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide.
    Varma MV; Lin J; Bi YA; Kimoto E; Rodrigues AD
    Drug Metab Dispos; 2015 Jul; 43(7):1108-18. PubMed ID: 25941268
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
    Kazmi F; Barbara JE; Yerino P; Parkinson A
    Drug Metab Dispos; 2015 Apr; 43(4):523-33. PubMed ID: 25595597
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats.
    Xu Y; Zhou D; Wang Y; Li J; Wang M; Lu J; Zhang H
    Food Chem Toxicol; 2016 Aug; 94():138-47. PubMed ID: 27259818
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Studies to further investigate the inhibition of human liver microsomal CYP2C8 by the acyl-β-glucuronide of gemfibrozil.
    Jenkins SM; Zvyaga T; Johnson SR; Hurley J; Wagner A; Burrell R; Turley W; Leet JE; Philip T; Rodrigues AD
    Drug Metab Dispos; 2011 Dec; 39(12):2421-30. PubMed ID: 21911547
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8.
    Takagi M; Sakamoto M; Itoh T; Fujiwara R
    Drug Metab Pharmacokinet; 2015 Aug; 30(4):288-94. PubMed ID: 26195223
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
    Itkonen MK; Tornio A; Neuvonen M; Neuvonen PJ; Niemi M; Backman JT
    Drug Metab Dispos; 2019 Apr; 47(4):377-385. PubMed ID: 30630815
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Physiologically Based Pharmacokinetic Modeling Suggests Limited Drug-Drug Interaction Between Clopidogrel and Dasabuvir.
    Shebley M; Fu W; Badri P; Bow D; Fischer V
    Clin Pharmacol Ther; 2017 Oct; 102(4):679-687. PubMed ID: 28411400
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.
    Tornio A; Neuvonen PJ; Niemi M; Backman JT
    Expert Opin Drug Metab Toxicol; 2017 Jan; 13(1):83-95. PubMed ID: 27548563
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Clarification of the Mechanism of Clopidogrel-Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.
    Kim SJ; Yoshikado T; Ieiri I; Maeda K; Kimura M; Irie S; Kusuhara H; Sugiyama Y
    Drug Metab Dispos; 2016 Oct; 44(10):1622-32. PubMed ID: 27457785
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.
    Kajosaari LI; Laitila J; Neuvonen PJ; Backman JT
    Basic Clin Pharmacol Toxicol; 2005 Oct; 97(4):249-56. PubMed ID: 16176562
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.
    Hinton LK; Galetin A; Houston JB
    Pharm Res; 2008 May; 25(5):1063-74. PubMed ID: 17901929
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Utilizing PBPK Modeling to Evaluate the Potential of a Significant Drug-Drug Interaction Between Clopidogrel and Dasabuvir: A Scientific Perspective.
    Arya V; Zhao P; Reynolds KS; Mishra P; Younis IR
    Clin Pharmacol Ther; 2017 Oct; 102(4):578-580. PubMed ID: 28444890
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.