BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 28656523)

  • 1. Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity.
    Chen J; Sang Z; Li L; He L; Ma L
    Mol Divers; 2017 Aug; 21(3):637-654. PubMed ID: 28656523
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and structure-activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists.
    Negoro K; Yonetoku Y; Moritomo A; Hayakawa M; Iikubo K; Yoshida S; Takeuchi M; Ohta M
    Bioorg Med Chem; 2012 Nov; 20(21):6442-51. PubMed ID: 23010456
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes.
    Fang Y; Xu J; Li Z; Yang Z; Xiong L; Jin Y; Wang Q; Xie S; Zhu W; Chang S
    Bioorg Med Chem; 2018 Aug; 26(14):4080-4087. PubMed ID: 30100020
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus.
    Ha TY; Kim YS; Kim CH; Choi HS; Yang J; Park SH; Kim DH; Rhee JK
    Arch Pharm Res; 2014 May; 37(5):671-8. PubMed ID: 23897163
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists.
    Dai X; Stamford A; Liu H; Neustadt B; Hao J; Kowalski T; Hawes B; Xu X; Baker H; O'Neill K; Woods M; Tang H; Greenlee W
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5291-4. PubMed ID: 26433449
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of orally active sulfonylphenyl thieno[3,2-d]pyrimidine derivatives as GPR119 agonists.
    Kim H; Kim M; Oh K; Lee S; Lim S; Lee S; Kim YH; Suh KH; Min KH
    Eur J Med Chem; 2023 Oct; 258():115584. PubMed ID: 37356344
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists.
    Gillespie P; Goodnow RA; Saha G; Bose G; Moulik K; Zwingelstein C; Myers M; Conde-Knape K; Pietranico-Cole S; So SS
    Bioorg Med Chem Lett; 2014 Feb; 24(3):949-53. PubMed ID: 24412066
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists.
    Fang Y; Xiong L; Hu J; Zhang S; Xie S; Tu L; Wan Y; Jin Y; Li X; Hu S; Yang Z
    Bioorg Chem; 2019 May; 86():103-111. PubMed ID: 30685641
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Optimization of a novel series of potent and orally bioavailable GPR119 agonists.
    Koshizawa T; Morimoto T; Watanabe G; Watanabe T; Yamasaki N; Sawada Y; Fukuda T; Okuda A; Shibuya K; Ohgiya T
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3249-3253. PubMed ID: 28648463
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists.
    Negoro K; Yonetoku Y; Misawa-Mukai H; Hamaguchi W; Maruyama T; Yoshida S; Takeuchi M; Ohta M
    Bioorg Med Chem; 2012 Sep; 20(17):5235-46. PubMed ID: 22836190
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists.
    Jeon MK; Lee KM; Kim IH; Jang YK; Kang SK; Lee JM; Jung KY; Kumar JA; Rhee SD; Jung WH; Song JS; Bae MA; Kim KR; Ahn JH
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4281-5. PubMed ID: 25082125
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists.
    Yang Z; Fang Y; Pham TA; Lee J; Park H
    Bioorg Med Chem Lett; 2013 Mar; 23(5):1519-21. PubMed ID: 23374864
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.
    Kamaura M; Kubo O; Sugimoto H; Noguchi N; Miyashita H; Abe S; Matsuda K; Tsujihata Y; Odani T; Iwasaki S; Murata T; Sato K
    Bioorg Med Chem; 2021 Mar; 34():116034. PubMed ID: 33548803
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-
    Fang Y; Zhang S; Li M; Xiong L; Tu L; Xie S; Jin Y; Liu Y; Yang Z; Liu R
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):50-58. PubMed ID: 31656107
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists.
    Sato K; Sugimoto H; Rikimaru K; Imoto H; Kamaura M; Negoro N; Tsujihata Y; Miyashita H; Odani T; Murata T
    Bioorg Med Chem; 2014 Mar; 22(5):1649-66. PubMed ID: 24508142
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
    Alper P; Azimioara M; Cow C; Mutnick D; Nikulin V; Michellys PY; Wang Z; Reding E; Paliotti M; Li J; Bao D; Zoll J; Kim Y; Zimmerman M; Groessel T; Tuntland T; Joseph SB; McNamara P; Seidel HM; Epple R
    Bioorg Med Chem Lett; 2014 May; 24(10):2383-7. PubMed ID: 24751443
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.
    Katamreddy SR; Carpenter AJ; Ammala CE; Boros EE; Brashear RL; Briscoe CP; Bullard SR; Caldwell RD; Conlee CR; Croom DK; Hart SM; Heyer DO; Johnson PR; Kashatus JA; Minick DJ; Peckham GE; Ross SA; Roller SG; Samano VA; Sauls HR; Tadepalli SM; Thompson JB; Xu Y; Way JM
    J Med Chem; 2012 Dec; 55(24):10972-94. PubMed ID: 23214471
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and biological evaluation of 2-(4-(methylsulfonyl)phenyl)pyridine derivatives as GPR119 agonists.
    Zhou Y; Zhu X; Zhang L; Tang C; Feng B
    Chem Biol Drug Des; 2019 Jan; 93(1):67-74. PubMed ID: 30120879
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synergistic Effects of a GPR119 Agonist with Metformin on Weight Loss in Diet-Induced Obese Mice.
    Al-Barazanji K; McNulty J; Binz J; Generaux C; Benson W; Young A; Chen L
    J Pharmacol Exp Ther; 2015 Jun; 353(3):496-504. PubMed ID: 25770135
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists.
    Negoro K; Yonetoku Y; Maruyama T; Yoshida S; Takeuchi M; Ohta M
    Bioorg Med Chem; 2012 Apr; 20(7):2369-75. PubMed ID: 22365911
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.