223 related articles for article (PubMed ID: 28657311)
21. Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model.
Jayaraman M; Fox BM; Hollingshead M; Kohlhagen G; Pommier Y; Cushman M
J Med Chem; 2002 Jan; 45(1):242-9. PubMed ID: 11754595
[TBL] [Abstract][Full Text] [Related]
22. Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity.
Elbadawi MM; Eldehna WM; Wang W; Agama KK; Pommier Y; Abe M
Eur J Med Chem; 2021 Apr; 215():113261. PubMed ID: 33631697
[TBL] [Abstract][Full Text] [Related]
23. Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors.
Zhao Q; Xu X; Xie Z; Liu X; You Q; Guo Q; Zhong Y; Li Z
Bioorg Med Chem Lett; 2016 Feb; 26(3):1068-1072. PubMed ID: 26725027
[TBL] [Abstract][Full Text] [Related]
24. Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.
Tardy C; Facompré M; Laine W; Baldeyrou B; García-Gravalos D; Francesch A; Mateo C; Pastor A; Jiménez JA; Manzanares I; Cuevas C; Bailly C
Bioorg Med Chem; 2004 Apr; 12(7):1697-712. PubMed ID: 15028262
[TBL] [Abstract][Full Text] [Related]
25. Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore.
Beck DE; Abdelmalak M; Lv W; Reddy PV; Tender GS; O'Neill E; Agama K; Marchand C; Pommier Y; Cushman M
J Med Chem; 2015 May; 58(9):3997-4015. PubMed ID: 25909279
[TBL] [Abstract][Full Text] [Related]
26. Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study.
Van HT; Khadka DB; Yang SH; Le TN; Cho SH; Zhao C; Lee IS; Kwon Y; Lee KT; Kim YC; Cho WJ
Bioorg Med Chem; 2011 Sep; 19(18):5311-20. PubMed ID: 21873069
[TBL] [Abstract][Full Text] [Related]
27. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.
Morrell A; Placzek M; Parmley S; Antony S; Dexheimer TS; Pommier Y; Cushman M
J Med Chem; 2007 Sep; 50(18):4419-30. PubMed ID: 17696418
[TBL] [Abstract][Full Text] [Related]
28. Investigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons.
Beck DE; Reddy PV; Lv W; Abdelmalak M; Tender GS; Lopez S; Agama K; Marchand C; Pommier Y; Cushman M
J Med Chem; 2016 Apr; 59(8):3840-53. PubMed ID: 27070999
[TBL] [Abstract][Full Text] [Related]
29. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles.
Singh M; Tandon V
Eur J Med Chem; 2011 Feb; 46(2):659-69. PubMed ID: 21186067
[TBL] [Abstract][Full Text] [Related]
30. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
Bioorg Med Chem Lett; 2004 Jul; 14(14):3659-63. PubMed ID: 15203138
[TBL] [Abstract][Full Text] [Related]
31. Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.
Lee CC; Chang DM; Huang KF; Chen CL; Chen TC; Lo Y; Guh JH; Huang HS
Bioorg Med Chem; 2013 Nov; 21(22):7125-33. PubMed ID: 24094433
[TBL] [Abstract][Full Text] [Related]
32. Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.
Liu W; Zhu L; Guo W; Zhuang C; Zhang Y; Sheng C; Cheng P; Yao J; Wang W; Dong G; Wang S; Miao Z; Zhang W
Eur J Med Chem; 2011 Jun; 46(6):2408-14. PubMed ID: 21463912
[TBL] [Abstract][Full Text] [Related]
33. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.
Seol Y; Zhang H; Agama K; Lorence N; Pommier Y; Neuman KC
Mol Cancer Ther; 2015 Nov; 14(11):2552-9. PubMed ID: 26351326
[TBL] [Abstract][Full Text] [Related]
34. Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
Cheng P; Zhu L; Guo W; Liu W; Yao J; Dong G; Zhang Y; Zhuang C; Sheng C; Miao Z; Zhang W
J Enzyme Inhib Med Chem; 2012 Jun; 27(3):437-42. PubMed ID: 21770860
[TBL] [Abstract][Full Text] [Related]
35. Synthesis, molecular modeling and biological evaluation of new benzo[4,5]thieno[3,2-b]pyran derivatives as topoisomerase I-DNA binary complex poisons.
Ahmed EM; Khalil NA; Zaher AF; Alhamaky SM; El-Zoghbi MS
Bioorg Chem; 2021 Jul; 112():104915. PubMed ID: 33905973
[TBL] [Abstract][Full Text] [Related]
36. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.
Zakharenko A; Dyrkheeva N; Lavrik O
Med Res Rev; 2019 Jul; 39(4):1427-1441. PubMed ID: 31004352
[TBL] [Abstract][Full Text] [Related]
37. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
Fox BM; Xiao X; Antony S; Kohlhagen G; Pommier Y; Staker BL; Stewart L; Cushman M
J Med Chem; 2003 Jul; 46(15):3275-82. PubMed ID: 12852757
[TBL] [Abstract][Full Text] [Related]
38. Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.
Zhang C; Li S; Ji L; Liu S; Li Z; Li S; Meng X
Bioorg Med Chem Lett; 2015 Oct; 25(20):4693-6. PubMed ID: 26384290
[TBL] [Abstract][Full Text] [Related]
39. Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
Cananzi S; Merlini L; Artali R; Beretta GL; Zaffaroni N; Dallavalle S
Bioorg Med Chem; 2011 Aug; 19(16):4971-84. PubMed ID: 21783369
[TBL] [Abstract][Full Text] [Related]
40. New modulated design and synthesis of quercetin-Cu(II)/Zn(II)-Sn2(IV) scaffold as anticancer agents: in vitro DNA binding profile, DNA cleavage pathway and Topo-I activity.
Tabassum S; Zaki M; Afzal M; Arjmand F
Dalton Trans; 2013 Jul; 42(27):10029-41. PubMed ID: 23715526
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
