These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

95 related articles for article (PubMed ID: 28657314)

  • 1. Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization.
    Quéméner A; Maillasson M; Arzel L; Sicard B; Vomiandry R; Mortier E; Dubreuil D; Jacques Y; Lebreton J; Mathé-Allainmat M
    J Med Chem; 2017 Jul; 60(14):6249-6272. PubMed ID: 28657314
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rational modification, synthesis and biological evaluation of N-substituted phthalazinone derivatives designed to target interleukine-15 protein.
    Smadja J; Quéméner A; Maillasson M; Sicard B; Leray A; Arzel L; Lebreton J; Mortier E; Dubreuil D; Mathé-Allainmat M
    Bioorg Med Chem; 2021 Jun; 39():116161. PubMed ID: 33932805
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors.
    Żyżyńska-Granica B; Trzaskowski B; Niewieczerzał S; Filipek S; Zegrocka-Stendel O; Dutkiewicz M; Krzeczyński P; Kowalewska M; Koziak K
    Eur J Med Chem; 2017 Aug; 136():543-547. PubMed ID: 28535470
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cutting Edge: Differential Fine-Tuning of IL-2- and IL-15-Dependent Functions by Targeting Their Common IL-2/15Rβ/γc Receptor.
    Meghnem D; Morisseau S; Frutoso M; Trillet K; Maillasson M; Barbieux I; Khaddage S; Leray I; Hildinger M; Quéméner A; Jacques Y; Mortier E
    J Immunol; 2017 Jun; 198(12):4563-4568. PubMed ID: 28507024
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation.
    Olsen SK; Ota N; Kishishita S; Kukimoto-Niino M; Murayama K; Uchiyama H; Toyama M; Terada T; Shirouzu M; Kanagawa O; Yokoyama S
    J Biol Chem; 2007 Dec; 282(51):37191-204. PubMed ID: 17947230
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exploration of the structural requirements of HIV-protease inhibitors using pharmacophore, virtual screening and molecular docking approaches for lead identification.
    Islam MA; Pillay TS
    J Mol Graph Model; 2015 Mar; 56():20-30. PubMed ID: 25541527
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of new IL-7Rα small-molecule agonists: a multi-computational approach.
    Lee JY; Lee K; Koh B
    SAR QSAR Environ Res; 2021 Sep; 32(9):719-729. PubMed ID: 34431428
    [TBL] [Abstract][Full Text] [Related]  

  • 8. IL-15Rα membrane anchorage in either
    Quéméner A; Morisseau S; Sousa RP; Trillet K; Maillasson M; Leray I; Jacques Y; Dion J; Barbieux I; Frutoso M; Laurent AD; Le Questel JY; Mortier E
    J Cell Sci; 2019 Dec; 133(5):. PubMed ID: 31653781
    [TBL] [Abstract][Full Text] [Related]  

  • 9. IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
    Chenoweth MJ; Mian MF; Barra NG; Alain T; Sonenberg N; Bramson J; Lichty BD; Richards CD; Ma A; Ashkar AA
    J Immunol; 2012 May; 188(9):4149-57. PubMed ID: 22447977
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.
    Russell MG; Carling RW; Atack JR; Bromidge FA; Cook SM; Hunt P; Isted C; Lucas M; McKernan RM; Mitchinson A; Moore KW; Narquizian R; Macaulay AJ; Thomas D; Thompson SA; Wafford KA; Castro JL
    J Med Chem; 2005 Mar; 48(5):1367-83. PubMed ID: 15743180
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure--Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1).
    Pulla VK; Sriram DS; Viswanadha S; Sriram D; Yogeeswari P
    J Chem Inf Model; 2016 Jan; 56(1):173-87. PubMed ID: 26636371
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.
    Carling RW; Moore KW; Street LJ; Wild D; Isted C; Leeson PD; Thomas S; O'Connor D; McKernan RM; Quirk K; Cook SM; Atack JR; Wafford KA; Thompson SA; Dawson GR; Ferris P; Castro JL
    J Med Chem; 2004 Mar; 47(7):1807-22. PubMed ID: 15027873
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha.
    Bouchaud G; Garrigue-Antar L; Solé V; Quéméner A; Boublik Y; Mortier E; Perdreau H; Jacques Y; Plet A
    J Mol Biol; 2008 Sep; 382(1):1-12. PubMed ID: 18656487
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors.
    Lu D; Liu J; Zhang Y; Liu F; Zeng L; Peng R; Yang L; Ying H; Tang W; Chen W; Zuo J; Tong X; Liu T; Hu Y
    Eur J Med Chem; 2018 Feb; 145():328-337. PubMed ID: 29335200
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist.
    Cho NC; Seo SH; Kim D; Shin JS; Ju J; Seong J; Seo SH; Lee I; Lee KT; Kim YK; No KT; Pae AN
    J Comput Aided Mol Des; 2016 Aug; 30(8):625-37. PubMed ID: 27600555
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations.
    Sousa RP; Laurent AD; Quéméner A; Mortier E; Questel JL
    Molecules; 2019 Sep; 24(18):. PubMed ID: 31500206
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Constructing an atomic-resolution model of human P2X7 receptor followed by pharmacophore modeling to identify potential inhibitors.
    Ahmadi M; Nowroozi A; Shahlaei M
    J Mol Graph Model; 2015 Sep; 61():243-61. PubMed ID: 26298810
    [TBL] [Abstract][Full Text] [Related]  

  • 18. No requirement of trans presentations of IL-15 for human CD8 T cell proliferation.
    Ota N; Takase M; Uchiyama H; Olsen SK; Kanagawa O
    J Immunol; 2010 Nov; 185(10):6041-8. PubMed ID: 20926799
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?
    Schluns KS; Stoklasek T; Lefrançois L
    Int J Biochem Cell Biol; 2005 Aug; 37(8):1567-71. PubMed ID: 15896666
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-Based Virtual Screening of Commercially Available Compound Libraries.
    Kireev D
    Methods Mol Biol; 2016; 1439():65-76. PubMed ID: 27316988
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.