BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

311 related articles for article (PubMed ID: 28674172)

  • 1. Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.
    Tang S; Wang IJ; Yue C; Takano H; Terzic B; Pance K; Lee JY; Cui Y; Coulter DA; Zhou Z
    J Neurosci; 2017 Aug; 37(31):7420-7437. PubMed ID: 28674172
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CDKL5 deficiency in forebrain glutamatergic neurons results in recurrent spontaneous seizures.
    Wang HT; Zhu ZA; Li YY; Lou SS; Yang G; Feng X; Xu W; Huang ZL; Cheng X; Xiong ZQ
    Epilepsia; 2021 Feb; 62(2):517-528. PubMed ID: 33400301
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.
    Bavley CC; Rice RC; Fischer DK; Fakira AK; Byrne M; Kosovsky M; Rizzo BK; Del Prete D; Alaedini A; Morón JA; Higgins JJ; D'Adamio L; Rajadhyaksha AM
    J Neurosci; 2018 Mar; 38(11):2780-2795. PubMed ID: 29459374
    [TBL] [Abstract][Full Text] [Related]  

  • 4. AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder.
    Yennawar M; White RS; Jensen FE
    J Neurosci; 2019 Jun; 39(24):4814-4828. PubMed ID: 30952813
    [TBL] [Abstract][Full Text] [Related]  

  • 5. CDKL5 Deficiency Augments Inhibitory Input into the Dentate Gyrus That Can Be Reversed by Deep Brain Stimulation.
    Hao S; Wang Q; Tang B; Wu Z; Yang T; Tang J
    J Neurosci; 2021 Oct; 41(43):9031-9046. PubMed ID: 34544833
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory.
    Okuda K; Takao K; Watanabe A; Miyakawa T; Mizuguchi M; Tanaka T
    PLoS One; 2018; 13(4):e0196587. PubMed ID: 29702698
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.
    Tang S; Terzic B; Wang IJ; Sarmiento N; Sizov K; Cui Y; Takano H; Marsh ED; Zhou Z; Coulter DA
    Nat Commun; 2019 Jun; 10(1):2655. PubMed ID: 31201320
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder.
    Fuchs C; Gennaccaro L; Trazzi S; Bastianini S; Bettini S; Lo Martire V; Ren E; Medici G; Zoccoli G; Rimondini R; Ciani E
    Neural Plast; 2018; 2018():9726950. PubMed ID: 29977282
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice.
    Fuchs C; Fustini N; Trazzi S; Gennaccaro L; Rimondini R; Ciani E
    Eur J Neurosci; 2018 May; 47(9):1054-1066. PubMed ID: 29603837
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Foxp1 in Forebrain Pyramidal Neurons Controls Gene Expression Required for Spatial Learning and Synaptic Plasticity.
    Araujo DJ; Toriumi K; Escamilla CO; Kulkarni A; Anderson AG; Harper M; Usui N; Ellegood J; Lerch JP; Birnbaum SG; Tucker HO; Powell CM; Konopka G
    J Neurosci; 2017 Nov; 37(45):10917-10931. PubMed ID: 28978667
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
    Okuda K; Kobayashi S; Fukaya M; Watanabe A; Murakami T; Hagiwara M; Sato T; Ueno H; Ogonuki N; Komano-Inoue S; Manabe H; Yamaguchi M; Ogura A; Asahara H; Sakagami H; Mizuguchi M; Manabe T; Tanaka T
    Neurobiol Dis; 2017 Oct; 106():158-170. PubMed ID: 28688852
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.
    Zhu ZA; Li YY; Xu J; Xue H; Feng X; Zhu YC; Xiong ZQ
    Cell Rep; 2023 Oct; 42(10):113202. PubMed ID: 37777961
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.
    Trovò L; Fuchs C; De Rosa R; Barbiero I; Tramarin M; Ciani E; Rusconi L; Kilstrup-Nielsen C
    Neurobiol Dis; 2020 May; 138():104791. PubMed ID: 32032735
    [TBL] [Abstract][Full Text] [Related]  

  • 14. CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder.
    Trazzi S; De Franceschi M; Fuchs C; Bastianini S; Viggiano R; Lupori L; Mazziotti R; Medici G; Lo Martire V; Ren E; Rimondini R; Zoccoli G; Bartesaghi R; Pizzorusso T; Ciani E
    Hum Mol Genet; 2018 May; 27(9):1572-1592. PubMed ID: 29474534
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.
    Wang IT; Allen M; Goffin D; Zhu X; Fairless AH; Brodkin ES; Siegel SJ; Marsh ED; Blendy JA; Zhou Z
    Proc Natl Acad Sci U S A; 2012 Dec; 109(52):21516-21. PubMed ID: 23236174
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder.
    Gao Y; Irvine EE; Eleftheriadou I; Naranjo CJ; Hearn-Yeates F; Bosch L; Glegola JA; Murdoch L; Czerniak A; Meloni I; Renieri A; Kinali M; Mazarakis ND
    Brain; 2020 Mar; 143(3):811-832. PubMed ID: 32125365
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers.
    Schroeder E; Yuan L; Seong E; Ligon C; DeKorver N; Gurumurthy CB; Arikkath J
    Mol Neurobiol; 2019 Jun; 56(6):4151-4162. PubMed ID: 30288694
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder.
    Fuchs C; Rimondini R; Viggiano R; Trazzi S; De Franceschi M; Bartesaghi R; Ciani E
    Neurobiol Dis; 2015 Oct; 82():298-310. PubMed ID: 26143616
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.
    Fuchs C; Trazzi S; Torricella R; Viggiano R; De Franceschi M; Amendola E; Gross C; Calzà L; Bartesaghi R; Ciani E
    Neurobiol Dis; 2014 Oct; 70(100):53-68. PubMed ID: 24952363
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.
    Tramarin M; Rusconi L; Pizzamiglio L; Barbiero I; Peroni D; Scaramuzza L; Guilliams T; Cavalla D; Antonucci F; Kilstrup-Nielsen C
    Hum Mol Genet; 2018 Jun; 27(12):2052-2063. PubMed ID: 29618004
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.