BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

358 related articles for article (PubMed ID: 28684414)

  • 1. Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
    Gonzalez E; Guengerich FP
    J Biol Chem; 2017 Aug; 292(32):13168-13185. PubMed ID: 28684414
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conformational selection dominates binding of steroids to human cytochrome P450 17A1.
    Guengerich FP; Wilkey CJ; Glass SM; Reddish MJ
    J Biol Chem; 2019 Jun; 294(26):10028-10041. PubMed ID: 31072872
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.
    Pallan PS; Nagy LD; Lei L; Gonzalez E; Kramlinger VM; Azumaya CM; Wawrzak Z; Waterman MR; Guengerich FP; Egli M
    J Biol Chem; 2015 Feb; 290(6):3248-68. PubMed ID: 25533464
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1).
    Lee SG; Kim V; Lee GH; Kim C; Jeong E; Guengerich FP; Kim D
    J Inorg Biochem; 2023 Mar; 240():112085. PubMed ID: 36640554
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.
    Peng HM; Im SC; Pearl NM; Turcu AF; Rege J; Waskell L; Auchus RJ
    Biochemistry; 2016 Aug; 55(31):4356-65. PubMed ID: 27426448
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conversion of pregnenolone to DHEA by human 17alpha-hydroxylase/17, 20-lyase (P450c17). Evidence that DHEA is produced from the released intermediate, 17alpha-hydroxypregnenolone.
    Soucy P; Luu-The V
    Eur J Biochem; 2000 Jun; 267(11):3243-7. PubMed ID: 10824109
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structures of human steroidogenic cytochrome P450 17A1 with substrates.
    Petrunak EM; DeVore NM; Porubsky PR; Scott EE
    J Biol Chem; 2014 Nov; 289(47):32952-64. PubMed ID: 25301938
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis.
    Guengerich FP; McCarty KD; Chapman JG; Tateishi Y
    J Biol Chem; 2021 Aug; 297(2):100969. PubMed ID: 34273352
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.
    Estrada DF; Laurence JS; Scott EE
    J Biol Chem; 2013 Jun; 288(23):17008-17018. PubMed ID: 23620596
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effect of mutations in porcine CYB5A and CYP17A1 on the metabolism of pregnenolone.
    Squires EJ; Gray MA; Lou Y
    J Steroid Biochem Mol Biol; 2019 Dec; 195():105469. PubMed ID: 31509771
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1).
    Guengerich FP; McCarty KD; Tateishi Y; Liu L
    Methods Enzymol; 2023; 689():39-63. PubMed ID: 37802581
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.
    Estrada DF; Skinner AL; Laurence JS; Scott EE
    J Biol Chem; 2014 May; 289(20):14310-20. PubMed ID: 24671419
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of cytochrome b5 in the modulation of the enzymatic activities of cytochrome P450 17α-hydroxylase/17,20-lyase (P450 17A1).
    Bhatt MR; Khatri Y; Rodgers RJ; Martin LL
    J Steroid Biochem Mol Biol; 2017 Jun; 170():2-18. PubMed ID: 26976652
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
    Katagiri M; Kagawa N; Waterman MR
    Arch Biochem Biophys; 1995 Mar; 317(2):343-7. PubMed ID: 7893148
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Active site proton delivery and the lyase activity of human CYP17A1.
    Khatri Y; Gregory MC; Grinkova YV; Denisov IG; Sligar SG
    Biochem Biophys Res Commun; 2014 Jan; 443(1):179-84. PubMed ID: 24299954
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Efficiency of the sulfate pathway in comparison to the Δ4- and Δ5-pathway of steroidogenesis in the porcine testis.
    Klymiuk MC; Neunzig J; Bernhardt R; Sánchez-Guijo A; Hartmann MF; Wudy SA; Schuler G
    J Steroid Biochem Mol Biol; 2018 May; 179():64-72. PubMed ID: 29107177
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tight binding of cytochrome b
    Kim D; Kim V; McCarty KD; Guengerich FP
    J Biol Chem; 2021; 296():100571. PubMed ID: 33753170
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural insights into the function of steroidogenic cytochrome P450 17A1.
    Yadav R; Petrunak EM; Estrada DF; Scott EE
    Mol Cell Endocrinol; 2017 Feb; 441():68-75. PubMed ID: 27566228
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme.
    Swart P; Lombard N; Swart AC; van der Merwe T; Murry BA; Nicol M; Ian Mason J
    Arch Biochem Biophys; 2003 Jan; 409(1):145-52. PubMed ID: 12464253
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Unveiling the crucial intermediates in androgen production.
    Mak PJ; Gregory MC; Denisov IG; Sligar SG; Kincaid JR
    Proc Natl Acad Sci U S A; 2015 Dec; 112(52):15856-61. PubMed ID: 26668369
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.