These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 28698053)

  • 1. Stable C-N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor.
    Hasegawa F; Kawamura K; Tsuchikawa H; Murata M
    Bioorg Med Chem; 2017 Aug; 25(16):4506-4511. PubMed ID: 28698053
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification.
    Liao Y; Jia X; Tang Y; Li S; Zang Y; Wang L; Cui ZN; Song G
    Bioorg Med Chem Lett; 2019 Nov; 29(22):126720. PubMed ID: 31610942
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata.
    Liu X; Luo HB; Huang YY; Bao JM; Tang GH; Chen YY; Wang J; Yin S
    Org Lett; 2014 Jan; 16(1):282-5. PubMed ID: 24328835
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pd-mediated functionalization of polysubstituted pyrroles: their evaluation as potential inhibitors of PDE4.
    Bhaskar Kumar T; Sumanth Ch; Vaishaly S; Srinivasa Rao M; Chandra Sekhar KB; Meda CL; Kandale A; Rambabu D; Rama Krishna G; Malla Reddy C; Shiva Kumar K; Parsa KV; Pal M
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5639-47. PubMed ID: 22871579
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Asymmetric Total Synthesis and Biological Evaluation of the Natural PDE4 Inhibitor Toddacoumalone.
    Hou KQ; Chen XP; Huang Y; Chan ASC; Luo HB; Xiong XF
    Org Lett; 2020 Jan; 22(2):584-588. PubMed ID: 31904969
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of 4,5,6,7-tetrahydro-1H-1,2-diazepin-7-one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors.
    Guariento S; Karawajczyk A; Bull JA; Marchini G; Bielska M; Iwanowa X; Bruno O; Fossa P; Giordanetto F
    Bioorg Med Chem Lett; 2017 Jan; 27(1):24-29. PubMed ID: 27890378
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as potential PDE4 inhibitors.
    Song G; Zhao D; Hu D; Li Y; Jin H; Cui Z
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4610-4. PubMed ID: 26320621
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors.
    Lin Y; Ahmed W; He M; Xiang X; Tang R; Cui ZN
    Eur J Med Chem; 2020 Dec; 207():112795. PubMed ID: 33002845
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.
    Zhao L; Guo Z; Chen Y; Hu T; Wu D; Zhu YF; Rowbottom M; Gross TD; Tucci FC; Struthers RS; Xie Q; Chen C
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3344-9. PubMed ID: 18442905
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors.
    Li YS; Tian H; Zhao DS; Hu DK; Liu XY; Jin HW; Song GP; Cui ZN
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3632-5. PubMed ID: 27289320
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis.
    Felding J; Sørensen MD; Poulsen TD; Larsen J; Andersson C; Refer P; Engell K; Ladefoged LG; Thormann T; Vinggaard AM; Hegardt P; Søhoel A; Nielsen SF
    J Med Chem; 2014 Jul; 57(14):5893-903. PubMed ID: 24984230
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of triazines as potent, selective and orally active PDE4 inhibitors.
    Gewald R; Grunwald C; Egerland U
    Bioorg Med Chem Lett; 2013 Aug; 23(15):4308-14. PubMed ID: 23806553
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Recent progress toward developing axial chirality bioactive compounds.
    Wang Z; Meng L; Liu X; Zhang L; Yu Z; Wu G
    Eur J Med Chem; 2022 Dec; 243():114700. PubMed ID: 36058089
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Revealing atropisomer axial chirality in drug discovery.
    LaPlante SR; Edwards PJ; Fader LD; Jakalian A; Hucke O
    ChemMedChem; 2011 Mar; 6(3):505-13. PubMed ID: 21360821
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Montmorillonite K-10 catalyzed green synthesis of 2,6-unsubstituted dihydropyridines as potential inhibitors of PDE4.
    Reddy TR; Reddy GR; Reddy LS; Meda CL; Parsa KV; Kumar KS; Lingappa Y; Pal M
    Eur J Med Chem; 2013 Apr; 62():395-404. PubMed ID: 23380174
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations.
    Lanman BA; Parsons AT; Zech SG
    Acc Chem Res; 2022 Oct; 55(20):2892-2903. PubMed ID: 36178208
    [TBL] [Abstract][Full Text] [Related]  

  • 17. C-C bond formation at C-2 of a quinoline ring: synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors.
    Kumar KS; Kiran Kumar S; Yogi Sreenivas B; Gorja DR; Kapavarapu R; Rambabu D; Rama Krishna G; Reddy CM; Basaveswara Rao MV; Parsa KV; Pal M
    Bioorg Med Chem; 2012 Apr; 20(7):2199-207. PubMed ID: 22386978
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel Roflumilast analogs as soft PDE4 inhibitors.
    Boland S; Alen J; Bourin A; Castermans K; Boumans N; Panitti L; Vanormelingen J; Leysen D; Defert O
    Bioorg Med Chem Lett; 2014 Sep; 24(18):4594-4597. PubMed ID: 25149511
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Aryne Atropisomers: Chiral Arynes for the Enantiospecific Synthesis of Atropisomers and Nanographene Atropisomers.
    Coquerel Y
    Acc Chem Res; 2023 Jan; 56(2):86-94. PubMed ID: 36595619
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
    Gràcia J; Buil MA; Castro J; Eichhorn P; Ferrer M; Gavaldà A; Hernández B; Segarra V; Lehner MD; Moreno I; Pagès L; Roberts RS; Serrat J; Sevilla S; Taltavull J; Andrés M; Cabedo J; Vilella D; Calama E; Carcasona C; Miralpeix M
    J Med Chem; 2016 Dec; 59(23):10479-10497. PubMed ID: 27933955
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.