These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
151 related articles for article (PubMed ID: 2871151)
1. Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model. Roberts MS; Rowland M J Pharm Pharmacol; 1986 Mar; 38(3):177-81. PubMed ID: 2871151 [TBL] [Abstract][Full Text] [Related]
2. Models of hepatic drug clearance: discrimination between the 'well stirred' and 'parallel-tube' models. Ahmad AB; Bennett PN; Rowland M J Pharm Pharmacol; 1983 Apr; 35(4):219-24. PubMed ID: 6133930 [TBL] [Abstract][Full Text] [Related]
3. Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation. Wang HJ; Benet LZ Drug Metab Dispos; 2019 Dec; 47(12):1397-1402. PubMed ID: 31563869 [TBL] [Abstract][Full Text] [Related]
4. Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination? Sodhi JK; Wang HJ; Benet LZ Drug Metab Dispos; 2020 Jul; 48(7):537-543. PubMed ID: 32305951 [TBL] [Abstract][Full Text] [Related]
5. Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data. Dong J; Park MS Eur J Pharm Sci; 2018 Nov; 124():46-60. PubMed ID: 30102979 [TBL] [Abstract][Full Text] [Related]
6. In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats. Higashikawa F; Murakami T; Kaneda T; Takano M J Pharm Pharmacol; 1999 Apr; 51(4):405-10. PubMed ID: 10385212 [TBL] [Abstract][Full Text] [Related]
7. Protein binding and hepatic clearance: discrimination between models of hepatic clearance with diazepam, a drug of high intrinsic clearance, in the isolated perfused rat liver preparation. Rowland M; Leitch D; Fleming G; Smith B J Pharmacokinet Biopharm; 1984 Apr; 12(2):129-47. PubMed ID: 6491897 [TBL] [Abstract][Full Text] [Related]
8. Physiologic models of hepatic drug clearance: influence of altered protein binding on the elimination of diclofenac in the isolated perfused rat liver. Hussein Z; Evans AM; Rowland M J Pharm Sci; 1993 Sep; 82(9):880-5. PubMed ID: 8229684 [TBL] [Abstract][Full Text] [Related]
9. Kinetics of S-adenosyl-L-methionine in isolated perfused rat liver and its effects on microsomal enzyme activity. Guaitani A; Gualano M; Villa P; Stramentinoli G; Bartosek I Eur J Drug Metab Pharmacokinet; 1979; 4(4):187-92. PubMed ID: 535598 [TBL] [Abstract][Full Text] [Related]
10. Mechanisms of lidocaine kinetics in the isolated perfused rat liver. II. Kinetics of steady state elimination. Saville BA; Gray MR; Tam YK Drug Metab Dispos; 1987; 15(1):17-21. PubMed ID: 2881753 [TBL] [Abstract][Full Text] [Related]
11. A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity. Roberts MS; Rowland M J Pharmacokinet Biopharm; 1986 Jun; 14(3):261-88. PubMed ID: 3783447 [TBL] [Abstract][Full Text] [Related]
12. Relative dispersions of intra-albumin transit times across rat and elasmobranch perfused livers, and implications for intra- and inter-species scaling of hepatic clearance using microsomal data. Roberts MS; Ballinger LN; Weiss M J Pharm Pharmacol; 1998 Aug; 50(8):865-70. PubMed ID: 9751450 [TBL] [Abstract][Full Text] [Related]
13. Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? Pang KS; Han YR; Noh K; Lee PI; Rowland M Biochem Pharmacol; 2019 Nov; 169():113596. PubMed ID: 31398312 [TBL] [Abstract][Full Text] [Related]
14. Application of the axial dispersion model of hepatic drug elimination to the kinetics of diazepam in the isolated perfused rat liver. Díaz-García JM; Evans AM; Rowland M J Pharmacokinet Biopharm; 1992 Apr; 20(2):171-93. PubMed ID: 1629795 [TBL] [Abstract][Full Text] [Related]
15. In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine. Boase S; Miners JO Br J Clin Pharmacol; 2002 Nov; 54(5):493-503. PubMed ID: 12445028 [TBL] [Abstract][Full Text] [Related]
16. Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin. Pang KS; Gillette JR J Pharmacol Exp Ther; 1978 Oct; 207(1):178-94. PubMed ID: 702339 [TBL] [Abstract][Full Text] [Related]
17. Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. Li P; Robertson TA; Zhang Q; Fletcher LM; Crawford DH; Weiss M; Roberts MS Pharm Res; 2012 Jun; 29(6):1658-69. PubMed ID: 22302523 [TBL] [Abstract][Full Text] [Related]
18. The kinetics of 4-nitrophenol conjugation by perfused livers and hepatic microsomes from streptozocin-induced diabetic rats. Morrison MH; Barber HE; Foschi PG; Hawksworth GM J Pharm Pharmacol; 1986 Mar; 38(3):188-94. PubMed ID: 2871153 [TBL] [Abstract][Full Text] [Related]
19. Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model. Hsu SH; Cheng AC; Chang TY; Pao LH; Hsiong CH; Wang HJ Biomed Pharmacother; 2021 Sep; 141():111855. PubMed ID: 34229248 [TBL] [Abstract][Full Text] [Related]
20. Modeling of hepatic elimination and organ distribution kinetics with the extended convection-dispersion model. Roberts MS; Anissimov YG J Pharmacokinet Biopharm; 1999 Aug; 27(4):343-82. PubMed ID: 10826128 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]