These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
486 related articles for article (PubMed ID: 28711701)
1. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents. Tian C; Wang M; Han Z; Fang F; Zhang Z; Wang X; Liu J Eur J Med Chem; 2017 Sep; 138():630-643. PubMed ID: 28711701 [TBL] [Abstract][Full Text] [Related]
2. Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents. Gao T; Zhang C; Shi X; Guo R; Zhang K; Gu J; Li L; Li S; Zheng Q; Cui M; Cui M; Gao X; Liu Y; Wang L Eur J Med Chem; 2019 Sep; 178():329-340. PubMed ID: 31200235 [TBL] [Abstract][Full Text] [Related]
3. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents. Gangjee A; Lin X; Kisliuk RL; McGuire JJ J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780 [TBL] [Abstract][Full Text] [Related]
4. Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis. Liu Y; Zhang C; Zhang H; Li M; Yuan J; Zhang Y; Zhou J; Guo H; Zhao L; Du Y; Wang L; Ren L Eur J Med Chem; 2015 Mar; 93():142-55. PubMed ID: 25668494 [TBL] [Abstract][Full Text] [Related]
5. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789 [TBL] [Abstract][Full Text] [Related]
6. Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase. Gangjee A; Jain HD; Kisliuk RL Bioorg Med Chem Lett; 2005 May; 15(9):2225-30. PubMed ID: 15837298 [TBL] [Abstract][Full Text] [Related]
7. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. Gangjee A; Vidwans A; Elzein E; McGuire JJ; Queener SF; Kisliuk RL J Med Chem; 2001 Jun; 44(12):1993-2003. PubMed ID: 11384244 [TBL] [Abstract][Full Text] [Related]
8. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). Gangjee A; Jain HD; Phan J; Lin X; Song X; McGuire JJ; Kisliuk RL J Med Chem; 2006 Feb; 49(3):1055-65. PubMed ID: 16451071 [TBL] [Abstract][Full Text] [Related]
9. Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase. Xing R; Zhang H; Yuan J; Zhang K; Li L; Guo H; Zhao L; Zhang C; Li S; Gao T; Liu Y; Wang L Eur J Med Chem; 2017 Oct; 139():531-541. PubMed ID: 28830032 [TBL] [Abstract][Full Text] [Related]
10. Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. Gangjee A; Zeng Y; McGuire JJ; Kisliuk RL J Med Chem; 2005 Aug; 48(16):5329-36. PubMed ID: 16078850 [TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents. Gangjee A; Yu J; Kisliuk RL; Haile WH; Sobrero G; McGuire JJ J Med Chem; 2003 Feb; 46(4):591-600. PubMed ID: 12570380 [TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. Gangjee A; Li W; Kisliuk RL; Cody V; Pace J; Piraino J; Makin J J Med Chem; 2009 Aug; 52(15):4892-902. PubMed ID: 19719239 [TBL] [Abstract][Full Text] [Related]
13. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents. Gangjee A; Zhu Y; Queener SF J Med Chem; 1998 Nov; 41(23):4533-41. PubMed ID: 9804692 [TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates. Gangjee A; Zeng Y; Talreja T; McGuire JJ; Kisliuk RL; Queener SF J Med Chem; 2007 Jun; 50(13):3046-53. PubMed ID: 17552508 [TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. Gangjee A; Li W; Yang J; Kisliuk RL J Med Chem; 2008 Jan; 51(1):68-76. PubMed ID: 18072727 [TBL] [Abstract][Full Text] [Related]
16. Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge. Li H; Fang F; Liu Y; Xue L; Wang M; Guo Y; Wang X; Tian C; Liu J; Zhang Z Bioorg Med Chem; 2018 May; 26(9):2674-2685. PubMed ID: 29691154 [TBL] [Abstract][Full Text] [Related]
17. Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents. Liu Y; Li M; Zhang H; Yuan J; Zhang C; Zhang K; Guo H; Zhao L; Du Y; Wang L; Ren L Eur J Med Chem; 2016 Jun; 115():245-56. PubMed ID: 27017552 [TBL] [Abstract][Full Text] [Related]
18. 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. Gangjee A; Jain HD; Phan J; Guo X; Queener SF; Kisliuk RL Bioorg Med Chem; 2010 Jan; 18(2):953-61. PubMed ID: 20056546 [TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates. Gangjee A; Yang J; McGuire JJ; Kisliuk RL Bioorg Med Chem; 2006 Dec; 14(24):8590-8. PubMed ID: 16990006 [TBL] [Abstract][Full Text] [Related]
20. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Kumar VP; Cisneros JA; Frey KM; Castellanos-Gonzalez A; Wang Y; Gangjee A; White AC; Jorgensen WL; Anderson KS Bioorg Med Chem Lett; 2014 Sep; 24(17):4158-61. PubMed ID: 25127103 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]