359 related articles for article (PubMed ID: 2871191)
1. Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Rosowsky A; Freisheim JH; Moran RG; Solan VC; Bader H; Wright JE; Radike-Smith M
J Med Chem; 1986 May; 29(5):655-60. PubMed ID: 2871191
[TBL] [Abstract][Full Text] [Related]
2. Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Rosowsky A; Bader H; Cucchi CA; Moran RG; Kohler W; Freisheim JH
J Med Chem; 1988 Jul; 31(7):1332-7. PubMed ID: 3385730
[TBL] [Abstract][Full Text] [Related]
3. Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Rosowsky A; Bader H; Kohler W; Freisheim JH; Moran RG
J Med Chem; 1988 Jul; 31(7):1338-44. PubMed ID: 2898531
[TBL] [Abstract][Full Text] [Related]
4. Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.
Rosowsky A; Bader H; Forsch RA; Moran RG; Freisheim JH
J Med Chem; 1988 Apr; 31(4):763-8. PubMed ID: 3351853
[TBL] [Abstract][Full Text] [Related]
5. Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.
Rosowsky A; Moran RC; Forsch RA; Radike-Smith M; Colman PD; Wick MM; Freisheim JH
Biochem Pharmacol; 1986 Oct; 35(19):3327-33. PubMed ID: 3768024
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
Rosowsky A; Moran RG; Freisheim JH; Bader H; Forsch RA; Solan VC
NCI Monogr; 1987; (5):145-52. PubMed ID: 3431589
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
Rosowsky A; Forsch RA; Bader H; Freisheim JH
J Med Chem; 1991 Apr; 34(4):1447-54. PubMed ID: 2016722
[TBL] [Abstract][Full Text] [Related]
8. Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
Rosowsky A; Bader H; Radike-Smith M; Cucchi CA; Wick MM; Freisheim JH
J Med Chem; 1986 Sep; 29(9):1703-9. PubMed ID: 3462394
[TBL] [Abstract][Full Text] [Related]
9. Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.
Rosowsky A; Forsch RA; Moran RG; Kohler W; Freisheim JH
J Med Chem; 1988 Jul; 31(7):1326-31. PubMed ID: 3385729
[TBL] [Abstract][Full Text] [Related]
10. Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity.
Rosowsky A; Bader H; Freisheim JH
J Med Chem; 1991 Jan; 34(1):203-8. PubMed ID: 1992118
[TBL] [Abstract][Full Text] [Related]
11. Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.
Rosowsky A; Solan VC; Forsch RA; Delcamp TJ; Baccanari DP; Freisheim JH
J Med Chem; 1987 Aug; 30(8):1463-9. PubMed ID: 3112397
[TBL] [Abstract][Full Text] [Related]
12. Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.
Rosowsky A; Forsch RA; Freisheim JH; Moran RG; Wick M
J Med Chem; 1984 May; 27(5):600-4. PubMed ID: 6546949
[TBL] [Abstract][Full Text] [Related]
13. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
McGuire JJ; Russell CA; Bolanowska WE; Freitag CM; Jones CS; Kalman TI
Cancer Res; 1990 Mar; 50(6):1726-31. PubMed ID: 2306727
[TBL] [Abstract][Full Text] [Related]
14. Methotrexate analogues--XVII. Antitumor activity of 4-amino-4-deoxy-N10-methylpteroyl-D,L-homocysteic acid and its dual inhibition of dihydrofolate reductase and folyl polyglutamate synthetase.
Rosowsky A; Moran RG; Forsch R; Colman P; Uren J; Wick M
Biochem Pharmacol; 1984 Jan; 33(1):155-61. PubMed ID: 6546690
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Rosowsky A; Bader H; Wright JE; Keyomarsi K; Matherly LH
J Med Chem; 1994 Jul; 37(14):2167-74. PubMed ID: 8035423
[TBL] [Abstract][Full Text] [Related]
16. Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Piper JR; Johnson CA; Maddry JA; Malik ND; McGuire JJ; Otter GM; Sirotnak FM
J Med Chem; 1993 Dec; 36(26):4161-71. PubMed ID: 8277497
[TBL] [Abstract][Full Text] [Related]
17. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Sirotnak FM
J Med Chem; 1986 Jun; 29(6):1080-7. PubMed ID: 2423690
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate.
Rosowsky A; Forsch RA; Moran RG; Freisheim JH
J Med Chem; 1991 Jan; 34(1):227-34. PubMed ID: 1992122
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.
Mao Z; Pan J; Kalman TI
J Med Chem; 1996 Oct; 39(21):4340-4. PubMed ID: 8863812
[TBL] [Abstract][Full Text] [Related]
20. Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids.
Piper JR; McCaleb GS; Montgomery JA; Schmid FA; Sirotnak FM
J Med Chem; 1985 Aug; 28(8):1016-25. PubMed ID: 4020824
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
