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5. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W; Bassell GJ; Kukar T Mol Neurodegener; 2016 Jun; 11(1):46. PubMed ID: 27341800 [TBL] [Abstract][Full Text] [Related]
6. Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia. Raitano S; Ordovàs L; De Muynck L; Guo W; Espuny-Camacho I; Geraerts M; Khurana S; Vanuytsel K; Tóth BI; Voets T; Vandenberghe R; Cathomen T; Van Den Bosch L; Vanderhaeghen P; Van Damme P; Verfaillie CM Stem Cell Reports; 2015 Jan; 4(1):16-24. PubMed ID: 25556567 [TBL] [Abstract][Full Text] [Related]
7. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by Holler CJ; Taylor G; Deng Q; Kukar T eNeuro; 2017; 4(4):. PubMed ID: 28828399 [TBL] [Abstract][Full Text] [Related]
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9. Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients. Valdez C; Wong YC; Schwake M; Bu G; Wszolek ZK; Krainc D Hum Mol Genet; 2017 Dec; 26(24):4861-4872. PubMed ID: 29036611 [TBL] [Abstract][Full Text] [Related]
11. Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia. Alquezar C; Esteras N; de la Encarnación A; Moreno F; López de Munain A; Martín-Requero Á Eur Neuropsychopharmacol; 2015 Mar; 25(3):386-403. PubMed ID: 25624003 [TBL] [Abstract][Full Text] [Related]
12. Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers. Alquézar C; de la Encarnación A; Moreno F; López de Munain A; Martín-Requero Á J Psychiatry Neurosci; 2016 Jun; 41(4):225-39. PubMed ID: 26624524 [TBL] [Abstract][Full Text] [Related]