787 related articles for article (PubMed ID: 28728898)
1. KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.
González-Bacerio J; Maluf SEC; Méndez Y; Pascual I; Florent I; Melo PMS; Budu A; Ferreira JC; Moreno E; Carmona AK; Rivera DG; Alonso Del Rivero M; Gazarini ML
Bioorg Med Chem; 2017 Sep; 25(17):4628-4636. PubMed ID: 28728898
[TBL] [Abstract][Full Text] [Related]
2. Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1.
Yang W; Riley BT; Lei X; Porebski BT; Kass I; Buckle AM; McGowan S
ChemMedChem; 2018 Dec; 13(23):2504-2513. PubMed ID: 30318749
[TBL] [Abstract][Full Text] [Related]
3. Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.
Skinner-Adams TS; Lowther J; Teuscher F; Stack CM; Grembecka J; Mucha A; Kafarski P; Trenholme KR; Dalton JP; Gardiner DL
J Med Chem; 2007 Nov; 50(24):6024-31. PubMed ID: 17960925
[TBL] [Abstract][Full Text] [Related]
4. Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.
Velmourougane G; Harbut MB; Dalal S; McGowan S; Oellig CA; Meinhardt N; Whisstock JC; Klemba M; Greenbaum DC
J Med Chem; 2011 Mar; 54(6):1655-66. PubMed ID: 21366301
[TBL] [Abstract][Full Text] [Related]
5. Screening and In Vitro Evaluation of Potential Plasmodium falciparum Leucyl Aminopeptidase Inhibitors.
Chaudhary M; Singh V; Anvikar AR; Sahi S
Curr Comput Aided Drug Des; 2016; 12(4):282-293. PubMed ID: 27449897
[TBL] [Abstract][Full Text] [Related]
6. Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.
Bounaadja L; Schmitt M; Albrecht S; Mouray E; Tarnus C; Florent I
Malar J; 2017 Sep; 16(1):382. PubMed ID: 28934959
[TBL] [Abstract][Full Text] [Related]
7. Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.
Flipo M; Beghyn T; Leroux V; Florent I; Deprez BP; Deprez-Poulain RF
J Med Chem; 2007 Mar; 50(6):1322-34. PubMed ID: 17326615
[TBL] [Abstract][Full Text] [Related]
8. Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
McGowan S; Oellig CA; Birru WA; Caradoc-Davies TT; Stack CM; Lowther J; Skinner-Adams T; Mucha A; Kafarski P; Grembecka J; Trenholme KR; Buckle AM; Gardiner DL; Dalton JP; Whisstock JC
Proc Natl Acad Sci U S A; 2010 Feb; 107(6):2449-54. PubMed ID: 20133789
[TBL] [Abstract][Full Text] [Related]
9. Overexpression of
Hoff CC; Azevedo MF; Thurler AB; Maluf SEC; Melo PMS; Del Rivero MA; González-Bacerio J; Carmona AK; Budu A; Gazarini ML
Pathogens; 2021 Nov; 10(11):. PubMed ID: 34832608
[No Abstract] [Full Text] [Related]
10. Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP).
Mathew R; Wunderlich J; Thivierge K; Cwiklinski K; Dumont C; Tilley L; Rohrbach P; Dalton JP
Sci Rep; 2021 Feb; 11(1):2854. PubMed ID: 33536500
[TBL] [Abstract][Full Text] [Related]
11. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Drinkwater N; Vinh NB; Mistry SN; Bamert RS; Ruggeri C; Holleran JP; Loganathan S; Paiardini A; Charman SA; Powell AK; Avery VM; McGowan S; Scammells PJ
Eur J Med Chem; 2016 Mar; 110():43-64. PubMed ID: 26807544
[TBL] [Abstract][Full Text] [Related]
12. Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.
Paiardini A; Bamert RS; Kannan-Sivaraman K; Drinkwater N; Mistry SN; Scammells PJ; McGowan S
PLoS One; 2015; 10(2):e0115859. PubMed ID: 25700165
[TBL] [Abstract][Full Text] [Related]
13. Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.
Mistry SN; Drinkwater N; Ruggeri C; Sivaraman KK; Loganathan S; Fletcher S; Drag M; Paiardini A; Avery VM; Scammells PJ; McGowan S
J Med Chem; 2014 Nov; 57(21):9168-83. PubMed ID: 25299353
[TBL] [Abstract][Full Text] [Related]
14. Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Ruggeri C; Drinkwater N; Sivaraman KK; Bamert RS; McGowan S; Paiardini A
PLoS One; 2015; 10(9):e0138957. PubMed ID: 26406322
[TBL] [Abstract][Full Text] [Related]
15. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.
McGowan S; Porter CJ; Lowther J; Stack CM; Golding SJ; Skinner-Adams TS; Trenholme KR; Teuscher F; Donnelly SM; Grembecka J; Mucha A; Kafarski P; Degori R; Buckle AM; Gardiner DL; Whisstock JC; Dalton JP
Proc Natl Acad Sci U S A; 2009 Feb; 106(8):2537-42. PubMed ID: 19196988
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.
Weldon DJ; Shah F; Chittiboyina AG; Sheri A; Chada RR; Gut J; Rosenthal PJ; Shivakumar D; Sherman W; Desai P; Jung JC; Avery MA
Bioorg Med Chem Lett; 2014 Mar; 24(5):1274-9. PubMed ID: 24507921
[TBL] [Abstract][Full Text] [Related]
17. The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations.
Jones PM; Robinson MW; Dalton JP; George AM
PLoS One; 2011; 6(12):e28589. PubMed ID: 22205955
[TBL] [Abstract][Full Text] [Related]
18. 3D QSAR, pharmacophore and molecular docking studies of known inhibitors and designing of novel inhibitors for M18 aspartyl aminopeptidase of Plasmodium falciparum.
Kumari M; Chandra S; Tiwari N; Subbarao N
BMC Struct Biol; 2016 Aug; 16():12. PubMed ID: 27534744
[TBL] [Abstract][Full Text] [Related]
19. Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Calic PPS; Vinh NB; Webb CT; Malcolm TR; Ngo A; Lowes K; Drinkwater N; McGowan S; Scammells PJ
Eur J Med Chem; 2023 Feb; 248():115051. PubMed ID: 36634455
[TBL] [Abstract][Full Text] [Related]
20. Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity.
Chen X; Chong CR; Shi L; Yoshimoto T; Sullivan DJ; Liu JO
Proc Natl Acad Sci U S A; 2006 Sep; 103(39):14548-53. PubMed ID: 16983082
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
