BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 28737909)

  • 1. Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers.
    Anthony NG; Baiget J; Berretta G; Boyd M; Breen D; Edwards J; Gamble C; Gray AI; Harvey AL; Hatziieremia S; Ho KH; Huggan JK; Lang S; Llona-Minguez S; Luo JL; McIntosh K; Paul A; Plevin RJ; Robertson MN; Scott R; Suckling CJ; Sutcliffe OB; Young LC; Mackay SP
    J Med Chem; 2017 Aug; 60(16):7043-7066. PubMed ID: 28737909
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The small-molecule inhibitor selectivity between IKKα and IKKβ kinases in NF-κB signaling pathway.
    Tian F; Zhou P; Kang W; Luo L; Fan X; Yan J; Liang H
    J Recept Signal Transduct Res; 2015; 35(4):307-18. PubMed ID: 25386663
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors.
    Park CH; Lee C; Yang JS; Joe BY; Chun K; Kim H; Kim HY; Kang JS; Lee JI; Kim MH; Han G
    Bioorg Med Chem Lett; 2014 Jun; 24(12):2655-60. PubMed ID: 24813730
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences.
    Patil KR; Mohapatra P; Patel HM; Goyal SN; Ojha S; Kundu CN; Patil CR
    PLoS One; 2015; 10(5):e0125709. PubMed ID: 25938234
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The IKKα-dependent non-canonical pathway of NF-κB activation is constitutively active and modulates progression-related functions in a subset of human melanomas.
    Dewert N; Amschler K; Lorenz V; Schön MP
    Arch Dermatol Res; 2016 Dec; 308(10):733-742. PubMed ID: 27744496
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected].
    Penzo M; Molteni R; Suda T; Samaniego S; Raucci A; Habiel DM; Miller F; Jiang HP; Li J; Pardi R; Palumbo R; Olivotto E; Kew RR; Bianchi ME; Marcu KB
    J Immunol; 2010 Apr; 184(8):4497-509. PubMed ID: 20231695
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation and function of IKK and IKK-related kinases.
    Häcker H; Karin M
    Sci STKE; 2006 Oct; 2006(357):re13. PubMed ID: 17047224
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of pyrrolopyrimidine inhibitors of Akt.
    Blake JF; Kallan NC; Xiao D; Xu R; Bencsik JR; Skelton NJ; Spencer KL; Mitchell IS; Woessner RD; Gloor SL; Risom T; Gross SD; Martinson M; Morales TH; Vigers GP; Brandhuber BJ
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5607-12. PubMed ID: 20810279
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects.
    Shin Y; Lim SM; Yan HH; Jung S; Fang Z; Jung KH; Hong SS; Hong S
    Eur J Med Chem; 2016 Nov; 123():544-556. PubMed ID: 27517803
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin.
    Tapia MA; González-Navarrete I; Dalmases A; Bosch M; Rodriguez-Fanjul V; Rolfe M; Ross JS; Mezquita J; Mezquita C; Bachs O; Gascón P; Rojo F; Perona R; Rovira A; Albanell J
    Cell Cycle; 2007 Sep; 6(18):2284-92. PubMed ID: 17890907
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and biological evaluation of novel
    Xie X; Tu J; You H; Hu B
    Drug Des Devel Ther; 2017; 11():1439-1451. PubMed ID: 28553074
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.
    Luftig M; Yasui T; Soni V; Kang MS; Jacobson N; Cahir-McFarland E; Seed B; Kieff E
    Proc Natl Acad Sci U S A; 2004 Jan; 101(1):141-6. PubMed ID: 14691250
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
    McIver EG; Bryans J; Birchall K; Chugh J; Drake T; Lewis SJ; Osborne J; Smiljanic-Hurley E; Tsang W; Kamal A; Levy A; Newman M; Taylor D; Arthur JS; Clark K; Cohen P
    Bioorg Med Chem Lett; 2012 Dec; 22(23):7169-73. PubMed ID: 23099093
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
    Senftleben U; Cao Y; Xiao G; Greten FR; Krähn G; Bonizzi G; Chen Y; Hu Y; Fong A; Sun SC; Karin M
    Science; 2001 Aug; 293(5534):1495-9. PubMed ID: 11520989
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis and evaluation of novel 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as potent, selective and reversible Bruton's tyrosine kinase (BTK) inhibitors for the treatment of rheumatoid arthritis.
    Zhang C; Pei H; He J; Zhu J; Li W; Niu T; Xiang M; Chen L
    Eur J Med Chem; 2019 May; 169():121-143. PubMed ID: 30875504
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel inhibitor of I-kappaB kinase beta ameliorates experimental arthritis through downregulation of proinflammatory cytokines in arthritic joints.
    Tanaka S; Toki T; Yokoyama M; Shimizu H; Yamasaki T; Yoneda Y; Muro F; Yasukochi T; Iimura S; Morishita K
    Biol Pharm Bull; 2014; 37(1):87-95. PubMed ID: 24389485
    [TBL] [Abstract][Full Text] [Related]  

  • 17. IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling.
    McIntosh K; Khalaf YH; Craig R; West C; McCulloch A; Waghmare A; Lawson C; Chan EYW; Mackay S; Paul A; Plevin R
    Cell Signal; 2023 Jul; 107():110684. PubMed ID: 37080443
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells.
    Ho CM; Donovan-Banfield IZ; Tan L; Zhang T; Gray NS; Strang BL
    PLoS One; 2016; 11(3):e0150339. PubMed ID: 26930276
    [TBL] [Abstract][Full Text] [Related]  

  • 19. IKKβ inhibitor identification: a multi-filter driven novel scaffold.
    Nagarajan S; Choo H; Cho YS; Shin KJ; Oh KS; Lee BH; Pae AN
    BMC Bioinformatics; 2010 Oct; 11 Suppl 7(Suppl 7):S15. PubMed ID: 21106122
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor.
    Pletz N; Schön M; Ziegelbauer K; Emmert S; Liu N; Dobbelstein M; Schön MP
    Exp Dermatol; 2012 Apr; 21(4):301-4. PubMed ID: 22320445
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.