BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

192 related articles for article (PubMed ID: 28751116)

  • 1. Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
    Hosogi J; Ohashi R; Maeda H; Tashiro S; Fuse E; Yamamoto Y; Kuwabara T
    Drug Metab Pharmacokinet; 2017 Oct; 32(5):255-264. PubMed ID: 28751116
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.
    Hosogi J; Ohashi R; Maeda H; Fujita K; Ushiki J; Kuwabara T; Yamamoto Y; Imamura T
    Biopharm Drug Dispos; 2018 Mar; 39(3):164-174. PubMed ID: 29451686
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
    Zhang JW; Deng HB; Zhang CY; Dai JQ; Li Q; Zheng QG; Wan HX; Yu HP; He F; Xu YC; Zhao S; Zhang JYJ
    Eur J Drug Metab Pharmacokinet; 2019 Oct; 44(5):669-680. PubMed ID: 31030415
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.
    Strelevitz TJ; Orozco CC; Obach RS
    Drug Metab Dispos; 2012 Jul; 40(7):1441-8. PubMed ID: 22522748
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism and clinical pharmacokinetics of 2-methyl-n-(2'-(pyrrolidinyl-1-ylsulfonyl)-n-[1,1'-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools.
    Sawant Basak A; Byon W; Tseng-Lovering E; Funk C; Wood L; Lin C; Delnomdedieu M; Verhoest P; Parikh V; Cox LM; Miller E; Gao H; Obach RS
    Xenobiotica; 2014 May; 44(5):438-54. PubMed ID: 24304147
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates.
    De Sousa Mendes M; L Orton A; Humphries HE; Jones B; Gardner I; Neuhoff S; Pilla Reddy V
    Drug Metab Dispos; 2020 Nov; 48(11):1231-1238. PubMed ID: 32893186
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors.
    Gökhan-Kelekçi N; Simşek OO; Ercan A; Yelekçi K; Sahin ZS; Işik S; Uçar G; Bilgin AA
    Bioorg Med Chem; 2009 Sep; 17(18):6761-72. PubMed ID: 19682910
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.
    Uehara S; Yoneda N; Higuchi Y; Yamazaki H; Suemizu H
    Drug Metab Dispos; 2020 Jul; 48(7):580-586. PubMed ID: 32357972
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Crouch RD; Morrison RD; Byers FW; Lindsley CW; Emmitte KA; Daniels JS
    Drug Metab Dispos; 2016 Aug; 44(8):1296-303. PubMed ID: 26936972
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu
    Crouch RD; Blobaum AL; Felts AS; Conn PJ; Lindsley CW
    Drug Metab Dispos; 2017 Dec; 45(12):1245-1259. PubMed ID: 28939686
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human.
    Erickson DA; Hollfelder S; Tenge J; Gohdes M; Burkhardt JJ; Krieter PA
    Drug Metab Dispos; 2007 Dec; 35(12):2232-41. PubMed ID: 17881661
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors.
    Tzvetkov NT; Stammler HG; Neumann B; Hristova S; Antonov L; Gastreich M
    Eur J Med Chem; 2017 Feb; 127():470-492. PubMed ID: 28107736
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.
    Hutzler JM; Cerny MA; Yang YS; Asher C; Wong D; Frederick K; Gilpin K
    Drug Metab Dispos; 2014 Oct; 42(10):1751-60. PubMed ID: 25035284
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A quantitative approach to hepatic clearance prediction of metabolism by aldehyde oxidase using custom pooled hepatocytes.
    Akabane T; Gerst N; Masters JN; Tamura K
    Xenobiotica; 2012 Sep; 42(9):863-71. PubMed ID: 22448773
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.
    Inoue H; Castagnoli K; Van Der Schyf C; Mabic S; Igarashi K; Castagnoli N
    J Pharmacol Exp Ther; 1999 Nov; 291(2):856-64. PubMed ID: 10525109
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles.
    Teffera Y; Liu J; Krolikowski P; Zhao Z
    Drug Metab Lett; 2021; 14(2):126-136. PubMed ID: 34818997
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Refinement of In Vitro Methods for Identification of Aldehyde Oxidase Substrates Reveals Metabolites of Kinase Inhibitors.
    Dick RA
    Drug Metab Dispos; 2018 Jun; 46(6):846-859. PubMed ID: 29615437
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.
    Tzvetkov NT; Hinz S; Küppers P; Gastreich M; Müller CE
    J Med Chem; 2014 Aug; 57(15):6679-703. PubMed ID: 24955776
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.
    Itoh K; Yamamura M; Takasaki W; Sasaki T; Masubuchi A; Tanaka Y
    Biopharm Drug Dispos; 2006 Apr; 27(3):133-9. PubMed ID: 16400710
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications.
    Diamond S; Boer J; Maduskuie TP; Falahatpisheh N; Li Y; Yeleswaram S
    Drug Metab Dispos; 2010 Aug; 38(8):1277-85. PubMed ID: 20421447
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.