These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 28751689)

  • 1. In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.
    Yoshino R; Yasuo N; Hagiwara Y; Ishida T; Inaoka DK; Amano Y; Tateishi Y; Ohno K; Namatame I; Niimi T; Orita M; Kita K; Akiyama Y; Sekijima M
    Sci Rep; 2017 Jul; 7(1):6666. PubMed ID: 28751689
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.
    Amano Y; Namatame I; Tateishi Y; Honboh K; Tanabe E; Niimi T; Sakashita H
    Acta Crystallogr D Biol Crystallogr; 2015 Sep; 71(Pt 9):1879-89. PubMed ID: 26327378
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi.
    Yamasaki K; Tani O; Tateishi Y; Tanabe E; Namatame I; Niimi T; Furukawa K; Sakashita H
    J Med Chem; 2016 Mar; 59(5):2261-6. PubMed ID: 26881725
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
    Hargrove TY; Wawrzak Z; Alexander PW; Chaplin JH; Keenan M; Charman SA; Perez CJ; Waterman MR; Chatelain E; Lepesheva GI
    J Biol Chem; 2013 Nov; 288(44):31602-15. PubMed ID: 24047900
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In silico tools to study molecular targets of neglected diseases: inhibition of TcSir2rp3, an epigenetic enzyme of Trypanosoma cruzi.
    López-López E; Barrientos-Salcedo C; Prieto-Martínez FD; Medina-Franco JL
    Adv Protein Chem Struct Biol; 2020; 122():203-229. PubMed ID: 32951812
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
    Gaspar L; Coron RP; KongThoo Lin P; Costa DM; Perez-Cabezas B; Tavares J; Roura-Ferrer M; Ramos I; Ronin C; Major LL; Ciesielski F; Pemberton IK; MacDougall J; Ciapetti P; Smith TK; Cordeiro-da-Silva A
    PLoS Negl Trop Dis; 2018 Jan; 12(1):e0006180. PubMed ID: 29357372
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A leishmaniasis study: structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase.
    Grover A; Katiyar SP; Singh SK; Dubey VK; Sundar D
    Biochim Biophys Acta; 2012 Dec; 1824(12):1476-83. PubMed ID: 22684087
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.
    Beig M; Oellien F; Garoff L; Noack S; Krauth-Siegel RL; Selzer PM
    PLoS Negl Trop Dis; 2015; 9(6):e0003773. PubMed ID: 26042772
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening.
    Melo-Filho CC; Braga RC; Muratov EN; Franco CH; Moraes CB; Freitas-Junior LH; Andrade CH
    Eur J Med Chem; 2019 Feb; 163():649-659. PubMed ID: 30562700
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease.
    King-Keller S; Li M; Smith A; Zheng S; Kaur G; Yang X; Wang B; Docampo R
    Antimicrob Agents Chemother; 2010 Sep; 54(9):3738-45. PubMed ID: 20625148
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
    Choe Y; Brinen LS; Price MS; Engel JC; Lange M; Grisostomi C; Weston SG; Pallai PV; Cheng H; Hardy LW; Hartsough DS; McMakin M; Tilton RF; Baldino CM; Craik CS
    Bioorg Med Chem; 2005 Mar; 13(6):2141-56. PubMed ID: 15727867
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.
    Dufe VT; Qiu W; Müller IB; Hui R; Walter RD; Al-Karadaghi S
    J Mol Biol; 2007 Oct; 373(1):167-77. PubMed ID: 17822713
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections.
    Buckner FS
    Adv Exp Med Biol; 2008; 625():61-80. PubMed ID: 18365659
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.
    Aguilera E; Varela J; Birriel E; Serna E; Torres S; Yaluff G; de Bilbao NV; Aguirre-López B; Cabrera N; Díaz Mazariegos S; de Gómez-Puyou MT; Gómez-Puyou A; Pérez-Montfort R; Minini L; Merlino A; Cerecetto H; González M; Alvarez G
    ChemMedChem; 2016 Jun; 11(12):1328-38. PubMed ID: 26492824
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis).
    Miller BR; Roitberg AE
    Future Med Chem; 2013 Oct; 5(15):1889-900. PubMed ID: 24144418
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.
    Avelar LA; Camilo CD; de Albuquerque S; Fernandes WB; Gonçalez C; Kenny PW; Leitão A; McKerrow JH; Montanari CA; Orozco EV; Ribeiro JF; Rocha JR; Rosini F; Saidel ME
    PLoS Negl Trop Dis; 2015; 9(7):e0003916. PubMed ID: 26173110
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A pharmacophore-based virtual screening approach for the discovery of Trypanosoma cruzi GAPDH inhibitors.
    Maluf FV; Andricopulo AD; Oliva G; Guido RV
    Future Med Chem; 2013 Nov; 5(17):2019-35. PubMed ID: 24215344
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase.
    Schormann N; Velu SE; Murugesan S; Senkovich O; Walker K; Chenna BC; Shinkre B; Desai A; Chattopadhyay D
    Bioorg Med Chem; 2010 Jun; 18(11):4056-66. PubMed ID: 20452776
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies.
    Sanz-Rodríguez CE; Concepción JL; Pekerar S; Oldfield E; Urbina JA
    J Biol Chem; 2007 Apr; 282(17):12377-87. PubMed ID: 17329254
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease.
    Beltran-Hortelano I; Perez-Silanes S; Galiano S
    Curr Med Chem; 2017 May; 24(11):1066-1138. PubMed ID: 28025938
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.