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4. Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. Prabhu VV; Talekar MK; Lulla AR; Kline CLB; Zhou L; Hall J; Van den Heuvel APJ; Dicker DT; Babar J; Grupp SA; Garnett MJ; McDermott U; Benes CH; Pu JJ; Claxton DF; Khan N; Oster W; Allen JE; El-Deiry WS Cell Cycle; 2018; 17(4):468-478. PubMed ID: 29157092 [TBL] [Abstract][Full Text] [Related]
5. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Wagner J; Kline CL; Ralff MD; Lev A; Lulla A; Zhou L; Olson GL; Nallaganchu BR; Benes CH; Allen JE; Prabhu VV; Stogniew M; Oster W; El-Deiry WS Cell Cycle; 2017 Oct; 16(19):1790-1799. PubMed ID: 28489985 [TBL] [Abstract][Full Text] [Related]
6. Discovery and clinical introduction of first-in-class imipridone ONC201. Allen JE; Kline CL; Prabhu VV; Wagner J; Ishizawa J; Madhukar N; Lev A; Baumeister M; Zhou L; Lulla A; Stogniew M; Schalop L; Benes C; Kaufman HL; Pottorf RS; Nallaganchu BR; Olson GL; Al-Mulla F; Duvic M; Wu GS; Dicker DT; Talekar MK; Lim B; Elemento O; Oster W; Bertino J; Flaherty K; Wang ML; Borthakur G; Andreeff M; Stein M; El-Deiry WS Oncotarget; 2016 Nov; 7(45):74380-74392. PubMed ID: 27602582 [TBL] [Abstract][Full Text] [Related]
7. The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma. Tu YS; He J; Liu H; Lee HC; Wang H; Ishizawa J; Allen JE; Andreeff M; Orlowski RZ; Davis RE; Yang J Neoplasia; 2017 Oct; 19(10):772-780. PubMed ID: 28863346 [TBL] [Abstract][Full Text] [Related]
8. Role of Dopamine Receptors in the Anticancer Activity of ONC201. Kline CLB; Ralff MD; Lulla AR; Wagner JM; Abbosh PH; Dicker DT; Allen JE; El-Deiry WS Neoplasia; 2018 Jan; 20(1):80-91. PubMed ID: 29216597 [TBL] [Abstract][Full Text] [Related]
9. Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo. Jhaveri AV; Zhou L; Ralff MD; Lee YS; Navaraj A; Carneiro BA; Safran H; Prabhu VV; Ross EA; Lee S; El-Deiry WS Cancer Biol Ther; 2021 Dec; 22(10-12):607-618. PubMed ID: 34856854 [TBL] [Abstract][Full Text] [Related]
10. ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer. Lev A; Lulla AR; Ross BC; Ralff MD; Makhov PB; Dicker DT; El-Deiry WS Mol Cancer Res; 2018 May; 16(5):754-766. PubMed ID: 29588330 [TBL] [Abstract][Full Text] [Related]
11. ONC201 induces cell death in pediatric non-Hodgkin's lymphoma cells. Talekar MK; Allen JE; Dicker DT; El-Deiry WS Cell Cycle; 2015 Aug; 14(15):2422-8. PubMed ID: 26030065 [TBL] [Abstract][Full Text] [Related]
12. Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells. Al Madhoun A; Haddad D; Al Tarrah M; Jacob S; Al-Ali W; Nizam R; Miranda L; Al-Rashed F; Sindhu S; Ahmad R; Bitar MS; Al-Mulla F Sci Rep; 2021 Jun; 11(1):11893. PubMed ID: 34088951 [TBL] [Abstract][Full Text] [Related]
13. Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms. Wagner J; Kline CL; Zhou L; Khazak V; El-Deiry WS J Exp Clin Cancer Res; 2018 Jan; 37(1):11. PubMed ID: 29357916 [TBL] [Abstract][Full Text] [Related]
14. Small Molecular TRAIL Inducer ONC201 Induces Death in Lung Cancer Cells: A Preclinical Study. Feng Y; Zhou J; Li Z; Jiang Y; Zhou Y PLoS One; 2016; 11(9):e0162133. PubMed ID: 27626799 [TBL] [Abstract][Full Text] [Related]
15. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Zhang Y; Zhou L; Safran H; Borsuk R; Lulla R; Tapinos N; Seyhan AA; El-Deiry WS Neoplasia; 2021 Aug; 23(8):792-810. PubMed ID: 34246076 [TBL] [Abstract][Full Text] [Related]
16. Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. Wang D; Fu L; Sun H; Guo L; DuBois RN Gastroenterology; 2015 Dec; 149(7):1884-1895.e4. PubMed ID: 26261008 [TBL] [Abstract][Full Text] [Related]
17. Targeting the Id1-Kif11 Axis in Triple-Negative Breast Cancer Using Combination Therapy. Thankamony AP; Murali R; Karthikeyan N; Varghese BA; Teo WS; McFarland A; Roden DL; Holliday H; Konrad CV; Cazet A; Dodson E; Yang J; Baker LA; George JT; Levine H; Jolly MK; Swarbrick A; Nair R Biomolecules; 2020 Sep; 10(9):. PubMed ID: 32911668 [TBL] [Abstract][Full Text] [Related]
18. First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent. Allen JE; Crowder RN; El-Deiry WS PLoS One; 2015; 10(11):e0143082. PubMed ID: 26580220 [TBL] [Abstract][Full Text] [Related]
19. Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway. Allen JE; Krigsfeld G; Patel L; Mayes PA; Dicker DT; Wu GS; El-Deiry WS Mol Cancer; 2015 May; 14():99. PubMed ID: 25927855 [TBL] [Abstract][Full Text] [Related]