These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

85 related articles for article (PubMed ID: 28780303)

  • 1. Computational analysis of Asp519 and Glu665 mutations of coagulation factor FVIIIa: Implications for enhanced binding affinity of A2-domain.
    Shearin S; Venkateswarlu D
    J Mol Graph Model; 2017 Sep; 76():441-447. PubMed ID: 28780303
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Role of hydrophobic mutations on the binding affinity and stability of blood coagulation factor VIIIa: a computational molecular dynamics and free-energy analysis.
    Venkateswarlu D
    Biochem Biophys Res Commun; 2014 Jul; 450(1):735-40. PubMed ID: 24952158
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Stabilizing interactions between D666-S1787 and T657-Y1792 at the A2-A3 interface support factor VIIIa stability in the blood clotting pathway.
    Monaghan M; Wakabayashi H; Griffiths AE; Fay PJ
    J Thromb Haemost; 2016 May; 14(5):1021-30. PubMed ID: 26878264
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants.
    Gale AJ; Radtke KP; Cunningham MA; Chamberlain D; Pellequer JL; Griffin JH
    J Thromb Haemost; 2006 Jun; 4(6):1315-22. PubMed ID: 16706977
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural investigation of zymogenic and activated forms of human blood coagulation factor VIII: a computational molecular dynamics study.
    Venkateswarlu D
    BMC Struct Biol; 2010 Feb; 10():7. PubMed ID: 20184747
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa.
    Pipe SW; Saenko EL; Eickhorst AN; Kemball-Cook G; Kaufman RJ
    Blood; 2001 Feb; 97(3):685-91. PubMed ID: 11157485
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hemophilia A mutations within the factor VIII A2-A3 subunit interface destabilize factor VIIIa and cause one-stage/two-stage activity discrepancy.
    Hakeos WH; Miao H; Sirachainan N; Kemball-Cook G; Saenko EL; Kaufman RJ; Pipe SW
    Thromb Haemost; 2002 Nov; 88(5):781-7. PubMed ID: 12428094
    [TBL] [Abstract][Full Text] [Related]  

  • 8. An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa.
    Gale AJ; Pellequer JL
    J Thromb Haemost; 2003 Sep; 1(9):1966-71. PubMed ID: 12941038
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Contribution of A1 subunit residue Q316 in thrombin-activated factor VIII to A2 subunit dissociation.
    Parker ET; Lollar P
    Biochemistry; 2007 Aug; 46(34):9737-42. PubMed ID: 17676877
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor Xase.
    Jenkins PV; Dill JL; Zhou Q; Fay PJ
    Biochemistry; 2004 May; 43(17):5094-101. PubMed ID: 15109268
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hydrogen-Deuterium Exchange Mass Spectrometry Identifies Activated Factor IX-Induced molecular Changes in Activated Factor VIII.
    van Galen J; Freato N; Przeradzka MA; Ebberink EHTM; Boon-Spijker M; van der Zwaan C; van den Biggelaar M; Meijer AB
    Thromb Haemost; 2021 May; 121(5):594-602. PubMed ID: 33302303
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A3 domain residue Glu1829 contributes to A2 subunit retention in factor VIIIa.
    Wakabayashi H; Zhou Q; Varfaj F; Fay PJ
    J Thromb Haemost; 2007 May; 5(5):996-1001. PubMed ID: 17371488
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa.
    Takeyama M; Wintermute JM; Manithody C; Rezaie AR; Fay PJ
    Biochemistry; 2013 Apr; 52(13):2228-35. PubMed ID: 23480827
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural insights into the interaction of blood coagulation co-factor VIIIa with factor IXa: a computational protein-protein docking and molecular dynamics refinement study.
    Venkateswarlu D
    Biochem Biophys Res Commun; 2014 Sep; 452(3):408-14. PubMed ID: 25157807
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Factor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa.
    Griffiths AE; Rydkin I; Fay PJ
    J Biol Chem; 2013 May; 288(21):15057-64. PubMed ID: 23580639
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa.
    Wakabayashi H; Wintermute JM; Fay PJ
    Thromb Haemost; 2014 Jul; 112(1):43-52. PubMed ID: 24599523
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation.
    Parker ET; Doering CB; Lollar P
    J Biol Chem; 2006 May; 281(20):13922-30. PubMed ID: 16513639
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.
    Wakabayashi H; Fay PJ
    Biochem J; 2013 Jun; 452(2):293-301. PubMed ID: 23521092
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit.
    Monaghan M; Wakabayashi H; Griffiths A; Wintermute J; Fay PJ
    Thromb Haemost; 2014 Sep; 112(3):495-502. PubMed ID: 24899227
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.
    Bloem E; Meems H; van den Biggelaar M; Mertens K; Meijer AB
    J Biol Chem; 2013 Sep; 288(36):26105-26111. PubMed ID: 23884417
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.