These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
256 related articles for article (PubMed ID: 28797172)
1. A decade of drug metabolite safety testing: industry and regulatory shared learning. Luffer-Atlas D; Atrakchi A Expert Opin Drug Metab Toxicol; 2017 Sep; 13(9):897-900. PubMed ID: 28797172 [No Abstract] [Full Text] [Related]
2. Overview of metabolite safety testing from an industry perspective. Anderson S; Knadler MP; Luffer-Atlas D Bioanalysis; 2010 Jul; 2(7):1249-61. PubMed ID: 21083238 [TBL] [Abstract][Full Text] [Related]
3. Drugs in control samples in nonclinical safety studies: a reconsideration. Zimmer D Bioanalysis; 2016 May; 8(10):1003-7. PubMed ID: 27080047 [No Abstract] [Full Text] [Related]
4. Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST). Takahashi RH; Khojasteh C; Wright M; Hop CECA; Ma S Drug Metab Lett; 2017 Nov; 11(1):21-28. PubMed ID: 28699487 [TBL] [Abstract][Full Text] [Related]
5. Toxicology Strategies for Drug Discovery - Present and Future: Introduction. Humphreys WG; Will Y; Guengerich FP Chem Res Toxicol; 2016 Apr; 29(4):437. PubMed ID: 27087588 [No Abstract] [Full Text] [Related]
6. Best practices for metabolite quantification in drug development: updated recommendation from the European Bioanalysis Forum. Timmerman P; Blech S; White S; Green M; Delatour C; McDougall S; Mannens G; Smeraglia J; Williams S; Young G Bioanalysis; 2016 Jun; 8(12):1297-305. PubMed ID: 27217058 [TBL] [Abstract][Full Text] [Related]
7. Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance. Yu H; Bischoff D; Tweedie D Expert Opin Drug Metab Toxicol; 2010 Dec; 6(12):1539-49. PubMed ID: 21067462 [TBL] [Abstract][Full Text] [Related]
8. Reactive Metabolites: Current and Emerging Risk and Hazard Assessments. Thompson RA; Isin EM; Ogese MO; Mettetal JT; Williams DP Chem Res Toxicol; 2016 Apr; 29(4):505-33. PubMed ID: 26735163 [TBL] [Abstract][Full Text] [Related]
10. The use of emerging safety biomarkers in nonclinical and clinical safety assessment - The current and future state: An IQ DruSafe industry survey. Zabka TS; Burkhardt J; Reagan WJ; Gautier JC; Glaab WE; Guffroy M; Harding J; Brees D; McDuffie E; Ramaiah L; Schultze AE; Smith JD; Wolfreys A; Dalmas DA Regul Toxicol Pharmacol; 2021 Mar; 120():104857. PubMed ID: 33387566 [TBL] [Abstract][Full Text] [Related]
11. Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals. Gao H; Obach RS Curr Drug Metab; 2011 Jul; 12(6):578-86. PubMed ID: 21434861 [TBL] [Abstract][Full Text] [Related]
12. Metabolites in safety testing. Robison TW; Jacobs A Bioanalysis; 2009 Oct; 1(7):1193-200. PubMed ID: 21083045 [TBL] [Abstract][Full Text] [Related]
13. Meeting report: metabolites in safety testing (MIST) symposium-safety assessment of human metabolites: what's REALLY necessary to ascertain exposure coverage in safety tests? Gao H; Jacobs A; White RE; Booth BP; Obach RS AAPS J; 2013 Oct; 15(4):970-3. PubMed ID: 23821354 [TBL] [Abstract][Full Text] [Related]
14. A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance. Schadt S; Bister B; Chowdhury SK; Funk C; Hop CECA; Humphreys WG; Igarashi F; James AD; Kagan M; Khojasteh SC; Nedderman ANR; Prakash C; Runge F; Scheible H; Spracklin DK; Swart P; Tse S; Yuan J; Obach RS Drug Metab Dispos; 2018 Jun; 46(6):865-878. PubMed ID: 29487142 [TBL] [Abstract][Full Text] [Related]
16. Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development. Leclercq L; Cuyckens F; Mannens GS; de Vries R; Timmerman P; Evans DC Chem Res Toxicol; 2009 Feb; 22(2):280-93. PubMed ID: 19183054 [TBL] [Abstract][Full Text] [Related]
17. Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules. Luker T; Alcaraz L; Chohan KK; Blomberg N; Brown DS; Butlin RJ; Elebring T; Griffin AM; Guile S; St-Gallay S; Swahn BM; Swallow S; Waring MJ; Wenlock MC; Leeson PD Bioorg Med Chem Lett; 2011 Oct; 21(19):5673-9. PubMed ID: 21852131 [TBL] [Abstract][Full Text] [Related]
18. Analysis of Pfizer compounds in EPA's ToxCast chemicals-assay space. Shah F; Greene N Chem Res Toxicol; 2014 Jan; 27(1):86-98. PubMed ID: 24328225 [TBL] [Abstract][Full Text] [Related]
19. Toxicology Strategies for Drug Discovery: Present and Future. Blomme EA; Will Y Chem Res Toxicol; 2016 Apr; 29(4):473-504. PubMed ID: 26588328 [TBL] [Abstract][Full Text] [Related]
20. Managing the challenge of chemically reactive metabolites in drug development. Park BK; Boobis A; Clarke S; Goldring CE; Jones D; Kenna JG; Lambert C; Laverty HG; Naisbitt DJ; Nelson S; Nicoll-Griffith DA; Obach RS; Routledge P; Smith DA; Tweedie DJ; Vermeulen N; Williams DP; Wilson ID; Baillie TA Nat Rev Drug Discov; 2011 Apr; 10(4):292-306. PubMed ID: 21455238 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]