224 related articles for article (PubMed ID: 28805801)
1. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Johannessen L; Sundberg TB; O'Connell DJ; Kolde R; Berstler J; Billings KJ; Khor B; Seashore-Ludlow B; Fassl A; Russell CN; Latorre IJ; Jiang B; Graham DB; Perez JR; Sicinski P; Phillips AJ; Schreiber SL; Gray NS; Shamji AF; Xavier RJ
Nat Chem Biol; 2017 Oct; 13(10):1102-1108. PubMed ID: 28805801
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of Cdk8/Cdk19 Activity Promotes Treg Cell Differentiation and Suppresses Autoimmune Diseases.
Guo Z; Wang G; Lv Y; Wan YY; Zheng J
Front Immunol; 2019; 10():1988. PubMed ID: 31552016
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
Offermann A; Joerg V; Becker F; Roesch MC; Kang D; Lemster AL; Tharun L; Behrends J; Merseburger AS; Culig Z; Sailer V; Brägelmann J; Kirfel J; Perner S
Am J Pathol; 2022 May; 192(5):813-823. PubMed ID: 35181333
[TBL] [Abstract][Full Text] [Related]
4. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.
Steinparzer I; Sedlyarov V; Rubin JD; Eislmayr K; Galbraith MD; Levandowski CB; Vcelkova T; Sneezum L; Wascher F; Amman F; Kleinova R; Bender H; Andrysik Z; Espinosa JM; Superti-Furga G; Dowell RD; Taatjes DJ; Kovarik P
Mol Cell; 2019 Nov; 76(3):485-499.e8. PubMed ID: 31495563
[TBL] [Abstract][Full Text] [Related]
5. Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition.
Chen M; Li J; Liang J; Thompson ZS; Kathrein K; Broude EV; Roninson IB
Cells; 2019 Nov; 8(11):. PubMed ID: 31717492
[TBL] [Abstract][Full Text] [Related]
6. Identification of target genes for the CDK subunits of the Mediator complex.
Tsutsui T; Fukasawa R; Tanaka A; Hirose Y; Ohkuma Y
Genes Cells; 2011 Dec; 16(12):1208-18. PubMed ID: 22117896
[TBL] [Abstract][Full Text] [Related]
7. Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
Mallinger A; Schiemann K; Rink C; Stieber F; Calderini M; Crumpler S; Stubbs M; Adeniji-Popoola O; Poeschke O; Busch M; Czodrowski P; Musil D; Schwarz D; Ortiz-Ruiz MJ; Schneider R; Thai C; Valenti M; de Haven Brandon A; Burke R; Workman P; Dale T; Wienke D; Clarke PA; Esdar C; Raynaud FI; Eccles SA; Rohdich F; Blagg J
J Med Chem; 2016 Feb; 59(3):1078-101. PubMed ID: 26796641
[TBL] [Abstract][Full Text] [Related]
8. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.
Audetat KA; Galbraith MD; Odell AT; Lee T; Pandey A; Espinosa JM; Dowell RD; Taatjes DJ
Mol Cell Biol; 2017 Jul; 37(13):. PubMed ID: 28416637
[TBL] [Abstract][Full Text] [Related]
9. CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
Chen M; Liang J; Ji H; Yang Z; Altilia S; Hu B; Schronce A; McDermott MSJ; Schools GP; Lim CU; Oliver D; Shtutman MS; Lu T; Stark GR; Porter DC; Broude EV; Roninson IB
Proc Natl Acad Sci U S A; 2017 Sep; 114(38):10208-10213. PubMed ID: 28855340
[TBL] [Abstract][Full Text] [Related]
10. Discovery and Development of Cyclin-Dependent Kinase 8 Inhibitors.
Lv X; Tian Y; Li S; Cheng K; Huang X; Kong H; Liao C; Xie Z
Curr Med Chem; 2020; 27(32):5429-5443. PubMed ID: 30947649
[TBL] [Abstract][Full Text] [Related]
11. Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease
Yan Y; Xing C; Xiao Y; Shen X; Zhang Z; He C; Shi JB; Liu M; Liu X
J Med Chem; 2022 May; 65(10):7334-7362. PubMed ID: 35536548
[TBL] [Abstract][Full Text] [Related]
12. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.
Hofmann MH; Mani R; Engelhardt H; Impagnatiello MA; Carotta S; Kerenyi M; Lorenzo-Herrero S; Böttcher J; Scharn D; Arnhof H; Zoephel A; Schnitzer R; Gerstberger T; Sanderson MP; Rajgolikar G; Goswami S; Vasu S; Ettmayer P; Gonzalez S; Pearson M; McConnell DB; Kraut N; Muthusamy N; Moll J
Mol Cancer Ther; 2020 Apr; 19(4):1018-1030. PubMed ID: 32024684
[TBL] [Abstract][Full Text] [Related]
13. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
Chen M; Li J; Zhang L; Wang L; Cheng C; Ji H; Altilia S; Ding X; Cai G; Altomare D; Shtutman M; Byrum SD; Mackintosh SG; Feoktistov A; Soshnikova N; Mogila VA; Tatarskiy V; Erokhin M; Chetverina D; Prawira A; Ni Y; Urban S; McInnes C; Broude EV; Roninson IB
Nucleic Acids Res; 2023 Aug; 51(14):7288-7313. PubMed ID: 37378433
[TBL] [Abstract][Full Text] [Related]
14. Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.
Butler M; Chotiwan N; Brewster CD; DiLisio JE; Ackart DF; Podell BK; Basaraba RJ; Perera R; Quackenbush SL; Rovnak J
Viruses; 2020 Jun; 12(6):. PubMed ID: 32560467
[TBL] [Abstract][Full Text] [Related]
15. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Dale T; Clarke PA; Esdar C; Waalboer D; Adeniji-Popoola O; Ortiz-Ruiz MJ; Mallinger A; Samant RS; Czodrowski P; Musil D; Schwarz D; Schneider K; Stubbs M; Ewan K; Fraser E; TePoele R; Court W; Box G; Valenti M; de Haven Brandon A; Gowan S; Rohdich F; Raynaud F; Schneider R; Poeschke O; Blaukat A; Workman P; Schiemann K; Eccles SA; Wienke D; Blagg J
Nat Chem Biol; 2015 Dec; 11(12):973-980. PubMed ID: 26502155
[TBL] [Abstract][Full Text] [Related]
16. A kinase-independent role for CDK8 in BCR-ABL1
Menzl I; Zhang T; Berger-Becvar A; Grausenburger R; Heller G; Prchal-Murphy M; Edlinger L; Knab VM; Uras IZ; Grundschober E; Bauer K; Roth M; Skucha A; Liu Y; Hatcher JM; Liang Y; Kwiatkowski NP; Fux D; Hoelbl-Kovacic A; Kubicek S; Melo JV; Valent P; Weichhart T; Grebien F; Zuber J; Gray NS; Sexl V
Nat Commun; 2019 Oct; 10(1):4741. PubMed ID: 31628323
[TBL] [Abstract][Full Text] [Related]
17. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
Brägelmann J; Klümper N; Offermann A; von Mässenhausen A; Böhm D; Deng M; Queisser A; Sanders C; Syring I; Merseburger AS; Vogel W; Sievers E; Vlasic I; Carlsson J; Andrén O; Brossart P; Duensing S; Svensson MA; Adler D; Kirfel J; Perner S
Clin Cancer Res; 2017 Apr; 23(7):1829-1840. PubMed ID: 27678455
[No Abstract] [Full Text] [Related]
18. Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.
Yamamoto S; Hagihara T; Horiuchi Y; Okui A; Wani S; Yoshida T; Inoue T; Tanaka A; Ito T; Hirose Y; Ohkuma Y
Genes Cells; 2017 Mar; 22(3):265-276. PubMed ID: 28151579
[TBL] [Abstract][Full Text] [Related]
19. CDK8: a positive regulator of transcription.
Galbraith MD; Donner AJ; Espinosa JM
Transcription; 2010; 1(1):4-12. PubMed ID: 21327159
[TBL] [Abstract][Full Text] [Related]
20. The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4
Arnett A; Moo KG; Flynn KJ; Sundberg TB; Johannessen L; Shamji AF; Gray NS; Decker T; Zheng Y; Gersuk VH; Rahman ZS; Levy DE; Marié IJ; Linsley PS; Xavier RJ; Khor B
Mol Cell Biol; 2021 Aug; 41(9):e0008521. PubMed ID: 34124936
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]