These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
424 related articles for article (PubMed ID: 28808917)
1. Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1. Khot A; Tibbitts J; Rock D; Shah DK AAPS J; 2017 Nov; 19(6):1715-1734. PubMed ID: 28808917 [TBL] [Abstract][Full Text] [Related]
2. Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1). Singh AP; Shah DK AAPS J; 2017 Jul; 19(4):1054-1070. PubMed ID: 28374319 [TBL] [Abstract][Full Text] [Related]
3. A mechanistic pharmacokinetic model elucidating the disposition of trastuzumab emtansine (T-DM1), an antibody-drug conjugate (ADC) for treatment of metastatic breast cancer. Bender B; Leipold DD; Xu K; Shen BQ; Tibbitts J; Friberg LE AAPS J; 2014 Sep; 16(5):994-1008. PubMed ID: 24917179 [TBL] [Abstract][Full Text] [Related]
4. Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates. Wada R; Erickson HK; Lewis Phillips GD; Provenzano CA; Leipold DD; Mai E; Johnson H; Tibbitts J Cancer Chemother Pharmacol; 2014 Nov; 74(5):969-80. PubMed ID: 25186956 [TBL] [Abstract][Full Text] [Related]
5. An integrated multiple-analyte pharmacokinetic model to characterize trastuzumab emtansine (T-DM1) clearance pathways and to evaluate reduced pharmacokinetic sampling in patients with HER2-positive metastatic breast cancer. Lu D; Joshi A; Wang B; Olsen S; Yi JH; Krop IE; Burris HA; Girish S Clin Pharmacokinet; 2013 Aug; 52(8):657-72. PubMed ID: 23553425 [TBL] [Abstract][Full Text] [Related]
6. Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1). Singh AP; Maass KF; Betts AM; Wittrup KD; Kulkarni C; King LE; Khot A; Shah DK AAPS J; 2016 Jul; 18(4):861-75. PubMed ID: 27029797 [TBL] [Abstract][Full Text] [Related]
7. A Phase I Pharmacokinetic Study of Trastuzumab Emtansine (T-DM1) in Patients with Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer and Normal or Reduced Hepatic Function. Li C; Agarwal P; Gibiansky E; Jin JY; Dent S; Gonçalves A; Nijem I; Strasak A; Harle-Yge ML; Chernyukhin N; LoRusso P; Girish S Clin Pharmacokinet; 2017 Sep; 56(9):1069-1080. PubMed ID: 27995530 [TBL] [Abstract][Full Text] [Related]
8. Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody-Drug Conjugate in Mice. Chang HP; Li Z; Shah DK Pharm Res; 2022 Jan; 39(1):1-24. PubMed ID: 35044590 [TBL] [Abstract][Full Text] [Related]
9. A Mechanism-Based PK/PD Model for Hematological Toxicities Induced by Antibody-Drug Conjugates. Ait-Oudhia S; Zhang W; Mager DE AAPS J; 2017 Sep; 19(5):1436-1448. PubMed ID: 28646408 [TBL] [Abstract][Full Text] [Related]
10. Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1. Betts A; Clark T; Jasper P; Tolsma J; van der Graaf PH; Graziani EI; Rosfjord E; Sung M; Ma D; Barletta F J Pharmacokinet Pharmacodyn; 2020 Oct; 47(5):513-526. PubMed ID: 32710210 [TBL] [Abstract][Full Text] [Related]
11. On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach. Haddish-Berhane N; Shah DK; Ma D; Leal M; Gerber HP; Sapra P; Barton HA; Betts AM J Pharmacokinet Pharmacodyn; 2013 Oct; 40(5):557-71. PubMed ID: 23933716 [TBL] [Abstract][Full Text] [Related]
12. Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC). Chen SC; Kagedal M; Gao Y; Wang B; Harle-Yge ML; Girish S; Jin J; Li C Cancer Chemother Pharmacol; 2017 Dec; 80(6):1147-1159. PubMed ID: 29043411 [TBL] [Abstract][Full Text] [Related]
13. Target-mediated drug disposition model and its approximations for antibody-drug conjugates. Gibiansky L; Gibiansky E J Pharmacokinet Pharmacodyn; 2014 Feb; 41(1):35-47. PubMed ID: 24322877 [TBL] [Abstract][Full Text] [Related]
14. Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy. Cilliers C; Guo H; Liao J; Christodolu N; Thurber GM AAPS J; 2016 Sep; 18(5):1117-1130. PubMed ID: 27287046 [TBL] [Abstract][Full Text] [Related]
15. Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics. Sukumaran S; Zhang C; Leipold DD; Saad OM; Xu K; Gadkar K; Samineni D; Wang B; Milojic-Blair M; Carrasco-Triguero M; Rubinfeld B; Fielder P; Lin K; Ramanujan S AAPS J; 2017 Jan; 19(1):130-140. PubMed ID: 27679517 [TBL] [Abstract][Full Text] [Related]
16. Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE. Singh AP; Shah DK Drug Metab Dispos; 2017 Nov; 45(11):1120-1132. PubMed ID: 28821484 [TBL] [Abstract][Full Text] [Related]
17. Preclinical Evaluation of Hartimath SV; Alizadeh E; Solomon VR; Chekol R; Bernhard W; Hill W; Parada AC; Barreto K; Geyer CR; Fonge H J Nucl Med; 2019 Aug; 60(8):1103-1110. PubMed ID: 30655327 [TBL] [Abstract][Full Text] [Related]
18. Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates. Ponte JF; Sun X; Yoder NC; Fishkin N; Laleau R; Coccia J; Lanieri L; Bogalhas M; Wang L; Wilhelm S; Widdison W; Pinkas J; Keating TA; Chari R; Erickson HK; Lambert JM Bioconjug Chem; 2016 Jul; 27(7):1588-98. PubMed ID: 27174129 [TBL] [Abstract][Full Text] [Related]
19. Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism. Shen BQ; Bumbaca D; Saad O; Yue Q; Pastuskovas CV; Khojasteh SC; Tibbitts J; Kaur S; Wang B; Chu YW; LoRusso PM; Girish S Curr Drug Metab; 2012 Sep; 13(7):901-10. PubMed ID: 22475269 [TBL] [Abstract][Full Text] [Related]