BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

221 related articles for article (PubMed ID: 28809961)

  • 1. Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.
    Xing W; Barauskas O; Kirschberg T; Niedziela-Majka A; Clarke M; Birkus G; Weissburg P; Liu X; Schultz BE; Sakowicz R; Kwon H; Feng JY
    PLoS One; 2017; 12(8):e0181969. PubMed ID: 28809961
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme.
    Shi L; Summers DF; Peng Q; Galarz JM
    Virology; 1995 Apr; 208(1):38-47. PubMed ID: 11831724
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.
    Fodor E; Crow M; Mingay LJ; Deng T; Sharps J; Fechter P; Brownlee GG
    J Virol; 2002 Sep; 76(18):8989-9001. PubMed ID: 12186883
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus.
    He X; Zhou J; Bartlam M; Zhang R; Ma J; Lou Z; Li X; Li J; Joachimiak A; Zeng Z; Ge R; Rao Z; Liu Y
    Nature; 2008 Aug; 454(7208):1123-6. PubMed ID: 18615018
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit.
    Dias A; Bouvier D; Crépin T; McCarthy AA; Hart DJ; Baudin F; Cusack S; Ruigrok RW
    Nature; 2009 Apr; 458(7240):914-8. PubMed ID: 19194459
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer.
    Chen KY; Santos Afonso ED; Enouf V; Isel C; Naffakh N
    PLoS Pathog; 2019 Oct; 15(10):e1008034. PubMed ID: 31581279
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Functional analysis of PA binding by influenza a virus PB1: effects on polymerase activity and viral infectivity.
    Perez DR; Donis RO
    J Virol; 2001 Sep; 75(17):8127-36. PubMed ID: 11483758
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Focusing on the Influenza Virus Polymerase Complex: Recent Progress in Drug Discovery and Assay Development.
    Zhang J; Hu Y; Musharrafieh R; Yin H; Wang J
    Curr Med Chem; 2019; 26(13):2243-2263. PubMed ID: 29984646
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation.
    Da Costa B; Sausset A; Munier S; Ghounaris A; Naffakh N; Le Goffic R; Delmas B
    J Virol; 2015 Jun; 89(12):6376-90. PubMed ID: 25855727
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.
    Reguera J; Weber F; Cusack S
    PLoS Pathog; 2010 Sep; 6(9):e1001101. PubMed ID: 20862319
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biochemical characterization of avian influenza viral polymerase containing PA or PB2 subunit from human influenza A virus.
    Pham PTV; Turan K; Nagata K; Kawaguchi A
    Microbes Infect; 2018; 20(6):353-359. PubMed ID: 29729434
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding.
    Hara K; Schmidt FI; Crow M; Brownlee GG
    J Virol; 2006 Aug; 80(16):7789-98. PubMed ID: 16873236
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.
    Jones JC; Kumar G; Barman S; Najera I; White SW; Webby RJ; Govorkova EA
    mBio; 2018 Apr; 9(2):. PubMed ID: 29691337
    [TBL] [Abstract][Full Text] [Related]  

  • 14. High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction.
    Tintori C; Laurenzana I; Fallacara AL; Kessler U; Pilger B; Stergiou L; Botta M
    Bioorg Med Chem Lett; 2014 Jan; 24(1):280-2. PubMed ID: 24314669
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
    Zima V; Radilová K; Kožíšek M; Albiñana CB; Karlukova E; Brynda J; Fanfrlík J; Flieger M; Hodek J; Weber J; Majer P; Konvalinka J; Machara A
    Eur J Med Chem; 2020 Dec; 208():112754. PubMed ID: 32883638
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Magnesium-dependent RNA binding to the PA endonuclease domain of the avian influenza polymerase.
    Xiao S; Klein ML; LeBard DN; Levine BG; Liang H; MacDermaid CM; Alfonso-Prieto M
    J Phys Chem B; 2014 Jan; 118(4):873-89. PubMed ID: 24404971
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site.
    Yuan P; Bartlam M; Lou Z; Chen S; Zhou J; He X; Lv Z; Ge R; Li X; Deng T; Fodor E; Rao Z; Liu Y
    Nature; 2009 Apr; 458(7240):909-13. PubMed ID: 19194458
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase.
    Suzuki T; Ainai A; Nagata N; Sata T; Sawa H; Hasegawa H
    Biochem Biophys Res Commun; 2011 Nov; 414(4):719-26. PubMed ID: 22001919
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.
    Yuan S; Chu H; Ye J; Singh K; Ye Z; Zhao H; Kao RY; Chow BK; Zhou J; Zheng BJ
    Antiviral Res; 2017 Jan; 137():58-66. PubMed ID: 27840201
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The N terminus of PA polymerase of swine-origin influenza virus H1N1 determines its compatibility with PB2 and PB1 subunits through a strain-specific amino acid serine 186.
    Wanitchang A; Jengarn J; Jongkaewwattana A
    Virus Res; 2011 Jan; 155(1):325-33. PubMed ID: 21056603
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.