BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

296 related articles for article (PubMed ID: 28810119)

  • 1. Conformational Flexibility of the Benzyl-Guanine Adduct in a Bypass Polymerase Active Site Permits Replication: Insights from Molecular Dynamics Simulations.
    Wilson KA; Wetmore SD
    Chem Res Toxicol; 2017 Nov; 30(11):2013-2022. PubMed ID: 28810119
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular Insights into the Translesion Synthesis of Benzyl-Guanine from Molecular Dynamics Simulations: Structural Evidence of Mutagenic and Nonmutagenic Replication.
    Wilson KA; Wetmore SD
    Biochemistry; 2017 Apr; 56(13):1841-1853. PubMed ID: 28290677
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferences.
    Perlow RA; Broyde S
    J Mol Biol; 2002 Sep; 322(2):291-309. PubMed ID: 12217692
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Extending the understanding of mutagenicity: structural insights into primer-extension past a benzo[a]pyrene diol epoxide-DNA adduct.
    Perlow RA; Broyde S
    J Mol Biol; 2003 Apr; 327(4):797-818. PubMed ID: 12654264
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV.
    Banerjee S; Brown KL; Egli M; Stone MP
    J Am Chem Soc; 2011 Aug; 133(32):12556-68. PubMed ID: 21790157
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Replication of the Aristolochic Acid I Adenine Adduct (ALI-N
    Kathuria P; Singh P; Sharma P; Wetmore SD
    Chem Res Toxicol; 2020 Oct; 33(10):2573-2583. PubMed ID: 32975111
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evading the proofreading machinery of a replicative DNA polymerase: induction of a mutation by an environmental carcinogen.
    Perlow RA; Broyde S
    J Mol Biol; 2001 Jun; 309(2):519-36. PubMed ID: 11371169
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct.
    Eoff RL; Stafford JB; Szekely J; Rizzo CJ; Egli M; Guengerich FP; Marnett LJ
    Biochemistry; 2009 Aug; 48(30):7079-88. PubMed ID: 19492857
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chlorine functionalization of a model phenolic C8-guanine adduct increases conformational rigidity and blocks extension by a Y-family DNA polymerase.
    Witham AA; Verwey AM; Sproviero M; Manderville RA; Sharma P; Wetmore SD
    Chem Res Toxicol; 2015 Jun; 28(6):1346-56. PubMed ID: 26004422
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase.
    Vyas R; Efthimiopoulos G; Tokarsky EJ; Malik CK; Basu AK; Suo Z
    J Am Chem Soc; 2015 Sep; 137(37):12131-42. PubMed ID: 26327169
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta.
    Choi JY; Guengerich FP
    J Mol Biol; 2005 Sep; 352(1):72-90. PubMed ID: 16061253
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications.
    Chandani S; Loechler EL
    J Mol Graph Model; 2009 Apr; 27(7):759-69. PubMed ID: 19188081
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ring-opening of the γ-OH-PdG adduct promotes error-free bypass by the Sulfolobus solfataricus DNA polymerase Dpo4.
    Shanmugam G; Minko IG; Banerjee S; Christov PP; Kozekov ID; Rizzo CJ; Lloyd RS; Egli M; Stone MP
    Chem Res Toxicol; 2013 Sep; 26(9):1348-60. PubMed ID: 23947567
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations.
    Liyanage PS; Walker AR; Brenlla A; Cisneros GA; Romano LJ; Rueda D
    Sci Rep; 2017 Dec; 7(1):17383. PubMed ID: 29234107
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanistic investigation of the bypass of a bulky aromatic DNA adduct catalyzed by a Y-family DNA polymerase.
    Gadkari VV; Tokarsky EJ; Malik CK; Basu AK; Suo Z
    DNA Repair (Amst); 2014 Sep; 21():65-77. PubMed ID: 25048879
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular dynamics of a food carcinogen-DNA adduct in a replicative DNA polymerase suggest hindered nucleotide incorporation and extension.
    Zhang L; Shapiro R; Broyde S
    Chem Res Toxicol; 2005 Sep; 18(9):1347-63. PubMed ID: 16167826
    [TBL] [Abstract][Full Text] [Related]  

  • 17. How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo[a]pyrene.
    Sholder G; Creech A; Loechler EL
    DNA Repair (Amst); 2015 Nov; 35():144-53. PubMed ID: 26523515
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
    Wong JH; Brown JA; Suo Z; Blum P; Nohmi T; Ling H
    EMBO J; 2010 Jun; 29(12):2059-69. PubMed ID: 20512114
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).
    Wang L; Broyde S
    Nucleic Acids Res; 2006; 34(3):785-95. PubMed ID: 16452300
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa.
    Jha V; Ling H
    DNA Repair (Amst); 2017 Jan; 49():43-50. PubMed ID: 27894903
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.